Open access

304 Discovering T cell proteome turnover dynamics to enhance persistence in solid tumors
Sydnye L Shuttleworth, Aaron J Storey, Michael A Bauer, Jessica L Kelliher, Lora J Rogers, Daniel Fil, Rick D Edmondson, Sam G Mackintosh, Alan J Tackett, Brian Koss

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A347; DOI: 10.1136/jitc-2023-SITC2023.0304
305 CAR positive cell selection: A versatile approach to purify CAR-T cells using anti-linker monoclonal antibodies attached to cleavable magnetic beads
Amrik Singh, Sarah L’Heureux, Jeremy Fisher

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A348; DOI: 10.1136/jitc-2023-SITC2023.0305
306 N-glycosylation inhibition hinders immunosuppressive tumor microenvironment cells improving CAR T cell efficacy
Camilla Sirini, Beatrice Greco, Chiara Balestrieri, Barbara Camisa, Elena Tiziano, Laura Falcone, Rita El Khoury, Oronzina Botrugno, Giovanni Tonon, Miriam Redegalli, Federica Pedica, Alice Bergamini, Fabio Ciceri, Chiara Bonini, Monica Casucci

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A349; DOI: 10.1136/jitc-2023-SITC2023.0306
307 CAR-Macrophages with custom intronic shRNA exhibit enhanced efficacy against solid tumors
Chris Sloas, Rashid Gabbasov, Nicholas Anderson, Yuhao Huangfu, Karan Nagar, Kerri Ciccaglione, Tierra Tobin, Nicholas Minutolo, Thomas Condamine, Michael Klichinsky, Yumi Ohtani

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A350; DOI: 10.1136/jitc-2023-SITC2023.0307
308 GUCY2C-directed CAR-T cell therapy for upper GI cancers
Ross Staudt, Megan Weindorfer, Amanda Lisby, Trevor Baybutt, Robert Carlson, Scott Waldman, Adam Snook

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A351; DOI: 10.1136/jitc-2023-SITC2023.0308
309 Protein Kinase C is an upstream regulator of IL13Ra2 and small molecular activator enhances CAR T mediated killing
Siddharth Subham, John Jeppson, Christine Brown, David Akhavan

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A352; DOI: 10.1136/jitc-2023-SITC2023.0309
310 Targeted delivery of a VEGF-blocking scFv to enhance CAR-T cell potency
Valentina Supper, Hannah Donner, Michael Kann, Filippo Birocchi, Felix Korell, Diego Salas-Benito, Stefanie Bailey, Tamina Kienka, Merle Philips, Nicholas Haradhvala, Amanda Bouffard, Bryan Choi, Marcela Maus, Mark Leick

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A353; DOI: 10.1136/jitc-2023-SITC2023.0310
311 Disruption of TGF-b signaling pathway is required to mediate effective killing of hepatocellular carcinoma by human iPSC-derived NK cells
Jaya Lakshmi Thangaraj, Michael Coffey, Dan S Kaufman

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A354; DOI: 10.1136/jitc-2023-SITC2023.0311
312 IL7 increases targeted lipid nanoparticle-mediated mRNA protein expression in T cells in vitro and in situ by enhancing T cell translation
Caitlin M Tilsed, Barzan A Sadiq, Tyler E Papp, Phurin Areesawangkit, Estela Noguera-Ortega, Kenji Kimura, Nicholas Cerda, Haig Aghajanian, Adrian Bot, Barbara Mui, Ying Tam, Drew Weissman, Steven M Albelda, Hamideh Parhiz

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A355; DOI: 10.1136/jitc-2023-SITC2023.0312
313 Enhancing anti-cancer activity of therapeutic T-cells with a synapse-stabilizing receptor
Chiou-Tsun Tsai, Norihiro Watanabe, Maksim Mamonkin

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A356; DOI: 10.1136/jitc-2023-SITC2023.0313

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