Open access

334 CAR T engagers encoding immune checkpoint inhibitors and immune-relevant cytokines stimulate CAR T cell activity against hematologic and solid tumors
Paul Rennert, Lan Wu, Lihe Su, Roy Lobb, Christine Ambrose

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A383; DOI: 10.1136/jitc-2023-SITC2023.0334
335 Towards an implantable replenishable delivery device for natural killer cell and Tri-specific killer engager antibodies to the intraperitoneal space to treat ovarian cancer
Aoibhin Sheedy, Carly Selleck, Niamh Ward, Lesley Trask, Garry Duffy, Melissa A Geller, Jeffrey S Miller, Eimear Dolan, Martin Felices

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A384; DOI: 10.1136/jitc-2023-SITC2023.0335
336 Significant myeloid and dendritic cellular enrichment of omidubicel graft suggests fast homeostatic proliferation of lymphoid populations
Dima Yackoubov, Stuart Levy, Roman Bengaiev, Eliran Arbib, Yaron Meirow, Efrat Landau, Yona Geffen

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A385; DOI: 10.1136/jitc-2023-SITC2023.0336
337 Homeostatic signals promote differentiation of memory T cell subsets that mediate sensitive IFN-
Nikhila Sham Sunder Bharadwaj, Jenny Gumperz

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A386; DOI: 10.1136/jitc-2023-SITC2023.0337
338 Comparison of lymphodepleting chemotherapy regimens as preconditioning for T-cell therapies
Oleg Demin, Galina Kolesova, Natalia Ramos-Hernandez, Thomas Faitg, Stefan Zajic, Lourdes Cucurull-Sanchez

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A387; DOI: 10.1136/jitc-2023-SITC2023.0338
339 Feeder-free expansion of autologous cytotoxic NK cells for acute myeloid leukemia treatment
Tim Dalessandri, Mahin Nikougoftar Zarif, Abhishek Maiti, Naval Daver, Anna-Karin Maltais

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A388; DOI: 10.1136/jitc-2023-SITC2023.0339
340 TGFβDNRII genetically-engineered TIL: characterizing final drug product from a phase I clinical trial
Katrina Adlerz, Ellgar Jafari, Jane Zulovich, Yue Li, Donald Sakellariou-Thompson, Marie-Andrée Forget, Priya Balasubramanian, Chantale Bernatchez, Rodabe Amaria, Jason Bock

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A389; DOI: 10.1136/jitc-2023-SITC2023.0340
341 γδ T cells support pancreatic cancer immunity by enhancing αβ T cell activation
Renee R Anderko, Pranav Murthy, Aatur Singhi, Alessandro Paniccia, Robbie Mailliard, Michael Lotze, Amer Zureikat

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A390; DOI: 10.1136/jitc-2023-SITC2023.0341
342 Improving TCR-T cell function against solid tumors with immune enhancing edits
Ishina Balwani, Nachiket Narendra Shevale, Erica Del Aguila, Ivy Dutta, Justin Oh, Nazia Ali, Nithila Saravanan, James Peter, Yurui Guo, Nishit Patel, Hanan Dahche, Jingyu Peng, Bo Han, Dai Liu, Amy Becker, Aaron Prodeus, Troy Luster, Birgit Schultes, Michael Lam

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A391; DOI: 10.1136/jitc-2023-SITC2023.0342
343 Defining and therapeutically targeting a fusion-derived public neoantigen in desmoplastic small round cell tumor using T-cell receptor gene therapy
Lauren Banks, Hannah Arkin, Smita S Chandran, Emily Slotkin, Neerav Shukla, Luc Morris, Andrew Kung, Martin Klatt, Christopher A Klebanoff

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A392; DOI: 10.1136/jitc-2023-SITC2023.0343

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