Open access

344 Human macrophages lacking NF-κB p50 display increased proinflammatory cytokine expression
Theresa Barberi, Alan D Friedman

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A393; DOI: 10.1136/jitc-2023-SITC2023.0344
345 Targeting acidity in bladder cancer to enhance efficacy of adoptive cell therapy (ACT) with tumor reactive T cells
Sarah Bazargan, Jamie Blauvelt, Amy Hall, Matthew Beatty, Michael Poch, Katarzyna A Rejniak, Shari Pilon-Thomas

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A394; DOI: 10.1136/jitc-2023-SITC2023.0345
346 Expansion and identification of neoantigen reactive tumor infiltrating lymphocytes (TIL) from metastatic colorectal (CRC) and GI cancers
Matthew Beatty, Madeline Rodriguez-Valentin, MacLean Hall, Fatema Khambati, Amy Hall, Larissa Pikor, Timothy J Langer, Barbara Sennino, Jamie Teer, Jason Fleming, Shari Pilon-Thomas

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A395; DOI: 10.1136/jitc-2023-SITC2023.0346
347 Functional characterization of GUCY2C-TAC T cells for the treatment of colorectal cancer using preclinical models
Tania Benatar, Thanyashanthi Nitya-Nootan, Gargi Thakor, Suzanna L Prosser, Philbert Ip, Prabha Lal, Alima Khan, Stacey X Xu, Sailaja Pirati, Deepika Bhemarasetty, Christopher W Helsen, Andreas G Bader

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A396; DOI: 10.1136/jitc-2023-SITC2023.0347
348 TIL engineered with membrane-bound IL15 (cytoTIL15™) are enriched for tumor-associated antigen reactivity and demonstrate pharmacologically tunable expansion and persistence in the presence of TAA
Rachel A Burga, Alonso Villasmil Ocando, Arman Aksoy, Kyle Pedro, Gauri Kulkarni, Meghan Langley, Benjamin Primack, Theresa Ross, Violet Young, Jeremy Tchaicha, Jan ter Meulen, Michelle Ols

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A397; DOI: 10.1136/jitc-2023-SITC2023.0348
349 A novel ‘off the shelf’ TCR-NK cell therapy platform for the treatment of solid tumours: development of optimised MAGE-A4 targeting TCR-NK cells for advancement into the clinic
Ines Cardoso, Sylvie Pollmann, Luise U Weigand

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A398; DOI: 10.1136/jitc-2023-SITC2023.0349
350 Enhancing directly selected tumor-reactive TIL function through genetic modification
Emily Carron, Sowbarnika Ratliff, April Fraley, Justin Rahman, Niloufar Khojandi, Bryant Thompson, Mathew Thayer, Christophe Pedros, Larissa Pikor, Barbara Sennino

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A399; DOI: 10.1136/jitc-2023-SITC2023.0350
351 Expansion of T cells from the cerebrospinal fluid of melanoma patients with leptomeningeal disease
Michael I Carter, MacLean Hall, Madeline Rodriguez-Valentin, Matthew Beatty, Peter Forsyth, Shari Pilon-Thomas, Yolanda Pina

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A400; DOI: 10.1136/jitc-2023-SITC2023.0351
352 Targeting glioblastoma with a TCR specific to the HLA-A*02-restricted, glioblastoma-associated antigen PTPRZ1
Yu-Chan Chih, Philipp Koopmann, Amelie Christina Dietsch, Dennis A Agardy, Alice De Roia, Alexandros Kourtesakis, Michael Kilian, Christopher Krämer, Edward Wilhelm Green, Agnieszka Blum, Victor Murcia Pie&nacute;kowski, Wolfgang Wick, Michael Platten, Lukas Bunse

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A401; DOI: 10.1136/jitc-2023-SITC2023.0352
353 Adoptively transferred Th17 cells engage host B cells for durable tumor destruction
Anna C Cole, Hannah M Knochelmann, Amalia M Rivera-Reyes, Aubrey S Smith, Megan M Wyatt, Bhavana Pavuluri, Guillermo O Rangel Rivera, Megen Wittling, Ayana T Ruffin, Soundharya Kumaresan, Jeremy M Boss, Gregory B Lesinski, Chrystal M Paulos

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A402; DOI: 10.1136/jitc-2023-SITC2023.0353

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