Open access

271 Development and characterisation of humanised scFv CAR-T therapies targeting BCMA against multiple myeloma
Jorge Illarramendi, Rebeca Martinez-Turrillas, Saray Rodriguez-Diaz, Patricia Jauregui, Paula Rodriguez-Marquez, Marta Gorraiz, Patricia Sarrion, Teresa Lozano, Elena Iglesias, Gisell Gabaldon, Candela Ceballos, Maria Cruz Viguria, Margarita Redondo, Susana Inoges, Asuncion Lopez-Diaz de Cerio, Antonio Pineda-Lucena, Juan Jose Lasarte, Juan Roberto Rodriguez-Madoz, Felipe Prosper

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A310-A311; DOI: 10.1136/jitc-2023-SITC2023.0271
272 PD-L1 CAR engineered K-NK cells to target PD-L1⁺ or PD-L1^- tumors
Hardikkumar Jetani, Pedro Romero, Andre Kunert, Katarzyna Franciszkiewicz, David Vlerick, Aleksandra Nowicka, Robert Y Igarashi

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A312; DOI: 10.1136/jitc-2023-SITC2023.0272
273 Hypermetabolic expansion conditions imprint lasting dysfunction on adoptive cell therapies
Supriya K Joshi, Konstantinos Lontos, Greg Delgoffe

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A313; DOI: 10.1136/jitc-2023-SITC2023.0273
274 Development of CTX112 a next generation allogeneic multiplexed CRISPR-edited CART cell therapy with disruptions of the TGFBR2 and Regnase-1 genes for improved manufacturing and potency
Demetrios Kalaitzidis, Mohammed Ghonime, Robert Chain, Nivedita Jaishankar, Davis Settipane, Zinkal Padalia, Lauren Zakas, Meghna Kuppuraju, Paul Tetteh, Mary-Lee Dequeant, Sushant Karnik, Chandirasegaran Massilamany, Brigid McEwan, Henia Dar, Melanie Allen, Laura Serwer, Thao Nguyen, Melanie Butler-Gauthier, Parin Sripakdeevong, Shashwat Nagar, Yin Tang, Nicole Flanagan, Elaine Huang, Shashwant Phuyal, Andrew Dunn, Elizabeth Koch, Erisa Sula, Jacob Waldman, Maria Lei Zhang, Cristian Loaiza, Erin Thorstensen, Keith Steiger, Katie Schum, Kayla Urbaez, Anna Ma, Annie Yang Weaver, Christopher Finch, Sarah Cohen, PK Morrow, Mark Benton, Jonathan Terrett

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A314; DOI: 10.1136/jitc-2023-SITC2023.0274
275 Inosine endows CAR T cells with features of increased stemness and anti-tumor potency
Dorota Klysz, Carley Fowler, Meena Malipatlolla, Lucille Stuani, Katherine A Freitas, Stefanie Meier, Bence Daniel, Katalin Sandor, Peng Xu, Jing Huang, Louai Labanieh, Amaury Leruste, Malek Bashti, Janette Mata-Alcazar, Vimal Keerthi, Nikolaos Gkitsas, Justin A Guerrero, Chris Fisher, Sunny Patel, Kyle Asano, Shabnum Patel, Kara L Davis, Ansuman T Satpathy, Steven A Feldman, Elena Sotillo, Crystal L Mackall

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A315; DOI: 10.1136/jitc-2023-SITC2023.0275
276 CAR-T cell effector function is prolonged by controlling JNK activation
Charles J Kuhlmann, Madison T Blucas, Chloe E Jepson, Jie Ren, Naoki Hama, Stella U Azolibe, Yoshiko N Kamata, Masakazu Kamata

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A316; DOI: 10.1136/jitc-2023-SITC2023.0276
277 SynNotch-CAR T cells demonstrate potent anti-tumor efficacy in a preclinical immunocompetent mouse model for glioblastoma
Senthilnath Lakshmanachetty, Milos Simic, Payal Watchmaker, Akane Yamamichi, Tiffany Chen, Su Phyu, Takahide Nejo, Chanelle Shepherd, Jason Duecker, Yuan Wang, Olga Troyanskaya, Lia Cardarelli, Sachdev Sidhu, Wendell Lim, Hideho Okada

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A317; DOI: 10.1136/jitc-2023-SITC2023.0277
278 Preclinical development of LYL119, a ROR1-targeted CAR T-cell product incorporating four novel T-cell reprogramming technologies to overcome barriers to effective cell therapy for solid tumors
Viola C Lam, Aileen Li, Meritxell Galindo Casas, Jessica Barragan, Christina Cheung, Jessica Briones, Esha Afreen, Grant Vavra, Jia Lu, Purnima Sundar, Rowena Martinez, Candace Sims, Christina Ta, Eskedar Nigatu, Shobha Potluri, Omar Ali, Alexander S Cheung, Rachel C Lynn

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A318-A319; DOI: 10.1136/jitc-2023-SITC2023.0278
279 Preclinical evaluation of allogeneic CD19 CAR T cells expressing an anti-rejection CD70 CAR
Elvin J Lauron, Kristen Zhang, Jerick Sanchez, Vidhya Ramanathan, Duy Nguyen, George Nguyen, Barbra Sasu, Cesar Sommer

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A320; DOI: 10.1136/jitc-2023-SITC2023.0279
280 Multiplex immunofluorescence imaging of armored CAR T cells in pancreatic ductal adenocarcinoma mouse xenografts confirms potent anti-tumor response
Jia-Jye Lee, Kathleen Baysac, Tri M Tran, Bal Krishna Chand Thakuri, Saule Nurmukhambetova, Ngoc Tran, Brittany Steimle, Peirong Hu, Dina Schneider

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A321; DOI: 10.1136/jitc-2023-SITC2023.0280

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