Open access

260 Novel CLL-1-directed CAR-T cells mediate potent antigen-specific cytolytic activity in mouse models of acute myeloid leukemia
Brikena Gjeci, Reid Williams, Hillary Hoyt, Amanda Halfond, Giacomo Canesin, Julia Etchin, Guy Mundelboim, Mariana Silva, John Lydeard, Julian Scherer, Tirtha Chakraborty

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A299; DOI: 10.1136/jitc-2023-SITC2023.0260
261 Synergistic antitumor effects of mouse mesothelin-directed CAR (mmeso-CAR) T cells and αCD40 in a syngeneic model of PDAC
Giulia Golinelli, Ting-Jia Fan, Khatuna Gabunia, Jordan Reff, David Mai, Omar Johnson, Zachary Ferraro, Decheng Song, Aasha Gupta, Mansi Deshmukh, Charles-Antoine Assenmacher, Enrico Radaelli, Daniel Martinez, Andrew Rech, Joseph A Fraietta, He N Xu, Wesley V Wilson, Julia C Tchou, Bruce L Levine, Regina M Young, John Scholler, Carl H June

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A300-A301; DOI: 10.1136/jitc-2023-SITC2023.0261
262 CAR-mast cell therapy for solid tumors
Jianjian Guo, Xiaolei Su

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A302; DOI: 10.1136/jitc-2023-SITC2023.0262
263 Unveiling the role of macrophages in CAR T-cell induced remodeling of the brain tumor immune microenvironment: implications for anti-glioma adoptive immunotherapy
Dalia Haydar, Jorge Ibanez, Jeremy Crawford, Zhongzhen Yi, Christopher DeRenzo, Stephen Gottschalk, Martine Roussel, Paul Thomas, Giedre Krenciute

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A303; DOI: 10.1136/jitc-2023-SITC2023.0263
264 Development of allogeneic, potency-edited, anti-GPC3 CAR-T cells for the treatment of hepatocellular carcinoma
Dan Henderson, Minh Pham, Dan Li, Mitchell Ho, Jason Sagert

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A304; DOI: 10.1136/jitc-2023-SITC2023.0264
265 ADI-925: an allogeneic off-the-shelf chimeric adapter (CAd) γδ T cell therapy targeting NKG2D ligand-expressing cancers
Marissa Herrman, Xue Yang, Maryam Tabrizizad, Louise Kiru, Taylor Barca, Morgan Smith-Boeck, Kyle McSweeney, Amy Doan, Kimberly Rodriquez, Jonathan Wong, Ramandeep Kaur, Smitha Rao Yelaguli Gundurao, Ngoc T Hoang, Hayden Tessman, Taylor Wingfield, Philip A Storm, Kevin P Nishimoto, Arun Bhat, Christopher J Rold, Swapna Panuganti, Blake T Aftab

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A305; DOI: 10.1136/jitc-2023-SITC2023.0265
267 Adapting orthotopic murine models of pancreatic cancer to enhance adoptive T cell immunotherapy
Natalie K Horvat, Isaac Karpovsky, Megan M Wyatt, Cameron Herting, Maggie Phillips, Jacklyn Hammons, Zaid Mahdi, Chrystal M Paulos, Gregory B Lesinski

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A306; DOI: 10.1136/jitc-2023-SITC2023.0267
268 Development of FT825/ONO-8250: an off-the-shelf CAR-T cell with preferential HER2 targeting and engineered to enable multi-antigen targeting, improve trafficking, and overcome immunosuppression
Martin Hosking, Soheila Shirinbak, Kyla Omilusik, Shilpi Chandra, Angela Gentile, Stephanie Kennedy, Lorraine Loter, Samad Ibitokou, Chris Ecker, Nicholas Brookhouser, Lauren Fong, Loraine Campanati, Xu Yuan, Karina Palomares, Yijia Pan, Shohreh Sikaroodi, Mika K Kaneko, Tatsuo Maeda, Daisuke Nakayama, Betsy Rezner, Eigen Peralta, Peter Szabo, Laura Chow, Raedun Clarke, Ramzey Abujarour, Tom Lee, Susumu Yamamoto, Yukinari Kato, Bahram Valamehr

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A307; DOI: 10.1136/jitc-2023-SITC2023.0268
269 CAR T cell production expands endogenous T cell repertoire recognizing additional tumor antigen(s)
Alicia Hou, Linchun Jin, Haipeng Tao, Duane A Mitchell, Jianping Huang

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A308; DOI: 10.1136/jitc-2023-SITC2023.0269
270 High-throughput discovery of constitutive promoters to drive strong expression of next-generation gene circuits in CAR-NK and -T cells
Tony Hua, Nicholas W Frankel, Ippolito I Caradonna, Assen Roguev, Karen L Chu, Russell M Gordley, Kanya Rajangam, Timothy K Lu

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A309; DOI: 10.1136/jitc-2023-SITC2023.0270

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