Open access

281 Development of syngeneic mouse models to study the therapeutic efficacy of chimeric antigen receptor T cells against solid tumors
Ping-Hsien Lee, Shannon Breen, Ashley Merlino, Lorenzo Ortiz, Rosa Carrasco, Gordon Moody, Allison Barrett, Letizia Giardino

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A322; DOI: 10.1136/jitc-2023-SITC2023.0281
282 Dual antigen targeting CAR T cells armored with a dominant-negative TGF-β Receptor II enhance antitumor potency by overcoming TGF-β immunosuppression in GBM
Nannan Li, Jesse Rodriguez, Zev Binder, Donald O’Rourke

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A323; DOI: 10.1136/jitc-2023-SITC2023.0282
283 Preclinical development and characterization of allogeneic CAR T cells targeting Claudin18.2-positive tumors
Zhe Li, Barbra Sasu, Siler Panowski

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A324; DOI: 10.1136/jitc-2023-SITC2023.0283
284 A novel hybrid T-cell receptor form of CAR-T cells showed enhanced activity against solid tumors
Meiou Liu, Yasushi Akahori, Hiroshi Fujiwara, Yoshihiro Miyahara

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A325; DOI: 10.1136/jitc-2023-SITC2023.0284
285 Proof-of-concept of a non-gene editing technology using shRNA down-regulation to engineer and optimize CAR T-cell functionality
Caroline Lonez, Jennifer Bolsee, Fanny Huberty, Thuy Nguyen, Celine Jacques-Hespel, Benjamin Demoulin, Anne Flament, Eytan Breman

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A326; DOI: 10.1136/jitc-2023-SITC2023.0285
286 Vaccine-boosted CAR T crosstalk with host immunity to reject tumors with antigen heterogeneity
Leyuan Ma

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A327-A328; DOI: 10.1136/jitc-2023-SITC2023.0286
287 Identification of potentially safe and selective CAR targets for head and neck cancer via a pan-cancer single cell transcriptome analysis
Sanna Madan, Eytan Ruppin

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A329; DOI: 10.1136/jitc-2023-SITC2023.0287
289 Defining the T cell functional attributes of effective CAR T cell donors
Michaela Meehl, Meghan W Dukes, Giedre Krenciute

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A330; DOI: 10.1136/jitc-2023-SITC2023.0289
290 IL-15 is required for optimal anti-tumor activity of Vγ9Vδ2 T cells against glioblastoma
Allyson E Moore, Nickolas Serniuck, Arya Afsahi, Hayley Nault, Sheila K Singh, Jonathan L Bramson

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A331; DOI: 10.1136/jitc-2023-SITC2023.0290
291 Time-resolved analysis of CAR-T cell induced apoptosis of low frequency target cells using an Image-enhanced flow cytometer was enabled by fluorescent protein compensation with BrightComp eBeads
Jayanth S Narayanan, Erin Taylor

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A332; DOI: 10.1136/jitc-2023-SITC2023.0291

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