Deep Learning MRI Models for the Differential Diagnosis of Tumefactive Demyelination versus IDH Wild-Type Glioblastoma

Gian Marco Conte; Mana Moassefi; Paul A. Decker; Matthew L. Kosel; Christina B. McCarthy; Jessica A. Sagen; Yalda Nikanpour; Mahboubeh Fereidan-Esfahani; Michael W. Ruff; Fiorella S. Guido; Heather K. Pump; Terry C. Burns; Robert B. Jenkins; Bradley J. Erickson; Daniel H. Lachance; W. Oliver Tobin; Jeanette E. Eckel-Passow

doi:10.3174/ajnr.A8645

Research ArticleARTIFICIAL INTELLIGENCE

Deep Learning MRI Models for the Differential Diagnosis of Tumefactive Demyelination versus IDH Wild-Type Glioblastoma

Gian Marco Conte, Mana Moassefi, Paul A. Decker, Matthew L. Kosel, Christina B. McCarthy, Jessica A. Sagen, Yalda Nikanpour, Mahboubeh Fereidan-Esfahani, Michael W. Ruff, Fiorella S. Guido, Heather K. Pump, Terry C. Burns, Robert B. Jenkins, Bradley J. Erickson, Daniel H. Lachance, W. Oliver Tobin and Jeanette E. Eckel-Passow

American Journal of Neuroradiology June 2025, DOI: https://doi.org/10.3174/ajnr.A8645

Gian Marco Conte

aFrom the Department of Radiology (G.M.C., M.M., Y.N., B.J.E.), Mayo Clinic, Rochester, Minnesota

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Mana Moassefi

aFrom the Department of Radiology (G.M.C., M.M., Y.N., B.J.E.), Mayo Clinic, Rochester, Minnesota

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Paul A. Decker

bDeptartment of Quantitative Health Sciences (P.A.D., M.L.K., J.E.E.-P.), Mayo Clinic, Rochester, Minnesota

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Matthew L. Kosel

bDeptartment of Quantitative Health Sciences (P.A.D., M.L.K., J.E.E.-P.), Mayo Clinic, Rochester, Minnesota

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Christina B. McCarthy

cDepartment of Neurology (C.B.M., J.A.S., M.W.R., F.S.G., H.K.P., D.H.L., W.O.T.), Mayo Clinic, Rochester, Minnesota

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Jessica A. Sagen

cDepartment of Neurology (C.B.M., J.A.S., M.W.R., F.S.G., H.K.P., D.H.L., W.O.T.), Mayo Clinic, Rochester, Minnesota

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Yalda Nikanpour

aFrom the Department of Radiology (G.M.C., M.M., Y.N., B.J.E.), Mayo Clinic, Rochester, Minnesota

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Mahboubeh Fereidan-Esfahani

dDell Medical School (M.F.-E.), University of Texas, Austin, Texas

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Michael W. Ruff

cDepartment of Neurology (C.B.M., J.A.S., M.W.R., F.S.G., H.K.P., D.H.L., W.O.T.), Mayo Clinic, Rochester, Minnesota

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Fiorella S. Guido

cDepartment of Neurology (C.B.M., J.A.S., M.W.R., F.S.G., H.K.P., D.H.L., W.O.T.), Mayo Clinic, Rochester, Minnesota

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Heather K. Pump

cDepartment of Neurology (C.B.M., J.A.S., M.W.R., F.S.G., H.K.P., D.H.L., W.O.T.), Mayo Clinic, Rochester, Minnesota

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Terry C. Burns

eDepartment of Neurosurgery (T.C.B.), Mayo Clinic, Rochester, Minnesota

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Robert B. Jenkins

fDepartment of Laboratory Medicine & Pathology (R.B.J.), Mayo Clinic, Rochester, Minnesota

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Bradley J. Erickson

aFrom the Department of Radiology (G.M.C., M.M., Y.N., B.J.E.), Mayo Clinic, Rochester, Minnesota

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Daniel H. Lachance

cDepartment of Neurology (C.B.M., J.A.S., M.W.R., F.S.G., H.K.P., D.H.L., W.O.T.), Mayo Clinic, Rochester, Minnesota

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W. Oliver Tobin

cDepartment of Neurology (C.B.M., J.A.S., M.W.R., F.S.G., H.K.P., D.H.L., W.O.T.), Mayo Clinic, Rochester, Minnesota

gCenter for Multiple Sclerosis and Autoimmune Neurology (W.O.T.), Mayo Clinic, Rochester, Minnesota

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Jeanette E. Eckel-Passow

bDeptartment of Quantitative Health Sciences (P.A.D., M.L.K., J.E.E.-P.), Mayo Clinic, Rochester, Minnesota

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Deep Learning MRI Models for the Differential Diagnosis of Tumefactive Demyelination versus IDH Wild-Type Glioblastoma

American Journal of Neuroradiology Jun 2025, DOI: 10.3174/ajnr.A8645

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MRI-Based Models for Diagnosis of Brain Lesions

American Journal of Neuroradiology Jun 2025, DOI: 10.3174/ajnr.A8645

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