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Research ArticleAdult Brain
Open Access

Deep Learning Segmentation of the Nucleus Basalis of Meynert on 3T MRI

D.J. Doss, G.W. Johnson, S. Narasimhan, J.S. Shless, J.W. Jiang, H.F.J. González, D.L. Paulo, A. Lucas, K.A. Davis, C. Chang, V.L. Morgan, C. Constantinidis, B.M. Dawant and D.J. Englot
American Journal of Neuroradiology August 2023, DOI: https://doi.org/10.3174/ajnr.A7950
D.J. Doss
aFrom the Department of Biomedical Engineering (D.J.D., G.W.J., S.N., H.F.J.G., C. Chang., V.L.M., C. Constantinidis, D.J.E.)
bInstitute of Imaging Science (D.J.D., G.W.J., S.N., J.S.S., J.W.J., H.F.J.G., C. Chang, V.L.M., B.M.D., D.J.E.)
fVanderbilt Institute for Surgery and Engineering (D.J.D., G.W.J., S.N., H.F.J.G., C. Chang, V.L.M., B.M.D., D.J.E.), Nashville, Tennessee
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  • ORCID record for D.J. Doss
G.W. Johnson
aFrom the Department of Biomedical Engineering (D.J.D., G.W.J., S.N., H.F.J.G., C. Chang., V.L.M., C. Constantinidis, D.J.E.)
bInstitute of Imaging Science (D.J.D., G.W.J., S.N., J.S.S., J.W.J., H.F.J.G., C. Chang, V.L.M., B.M.D., D.J.E.)
fVanderbilt Institute for Surgery and Engineering (D.J.D., G.W.J., S.N., H.F.J.G., C. Chang, V.L.M., B.M.D., D.J.E.), Nashville, Tennessee
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  • ORCID record for G.W. Johnson
S. Narasimhan
aFrom the Department of Biomedical Engineering (D.J.D., G.W.J., S.N., H.F.J.G., C. Chang., V.L.M., C. Constantinidis, D.J.E.)
bInstitute of Imaging Science (D.J.D., G.W.J., S.N., J.S.S., J.W.J., H.F.J.G., C. Chang, V.L.M., B.M.D., D.J.E.)
fVanderbilt Institute for Surgery and Engineering (D.J.D., G.W.J., S.N., H.F.J.G., C. Chang, V.L.M., B.M.D., D.J.E.), Nashville, Tennessee
gDepartments of Neurological Surgery (S.N., J.S.S., J.W.J., D.L.P., V.L.M., D.J.E.)
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J.S. Shless
bInstitute of Imaging Science (D.J.D., G.W.J., S.N., J.S.S., J.W.J., H.F.J.G., C. Chang, V.L.M., B.M.D., D.J.E.)
gDepartments of Neurological Surgery (S.N., J.S.S., J.W.J., D.L.P., V.L.M., D.J.E.)
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J.W. Jiang
bInstitute of Imaging Science (D.J.D., G.W.J., S.N., J.S.S., J.W.J., H.F.J.G., C. Chang, V.L.M., B.M.D., D.J.E.)
gDepartments of Neurological Surgery (S.N., J.S.S., J.W.J., D.L.P., V.L.M., D.J.E.)
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H.F.J. González
aFrom the Department of Biomedical Engineering (D.J.D., G.W.J., S.N., H.F.J.G., C. Chang., V.L.M., C. Constantinidis, D.J.E.)
bInstitute of Imaging Science (D.J.D., G.W.J., S.N., J.S.S., J.W.J., H.F.J.G., C. Chang, V.L.M., B.M.D., D.J.E.)
fVanderbilt Institute for Surgery and Engineering (D.J.D., G.W.J., S.N., H.F.J.G., C. Chang, V.L.M., B.M.D., D.J.E.), Nashville, Tennessee
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D.L. Paulo
gDepartments of Neurological Surgery (S.N., J.S.S., J.W.J., D.L.P., V.L.M., D.J.E.)
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A. Lucas
kDepartments of Bioengineering (A.L.)
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K.A. Davis
lNeuroscience (K.A.D.)
mCenter for Neuroengineering and Therapeutics (K.A.D.)
nDepartment of Neurology (K.A.D.), University of Pennsylvania, Philadelphia, Pennsylvania
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C. Chang
aFrom the Department of Biomedical Engineering (D.J.D., G.W.J., S.N., H.F.J.G., C. Chang., V.L.M., C. Constantinidis, D.J.E.)
bInstitute of Imaging Science (D.J.D., G.W.J., S.N., J.S.S., J.W.J., H.F.J.G., C. Chang, V.L.M., B.M.D., D.J.E.)
cDepartments of Electrical and Computer Engineering (C. Chang, B.M.D., D.J.E.)
dComputer Science (C. Chang)
fVanderbilt Institute for Surgery and Engineering (D.J.D., G.W.J., S.N., H.F.J.G., C. Chang, V.L.M., B.M.D., D.J.E.), Nashville, Tennessee
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V.L. Morgan
aFrom the Department of Biomedical Engineering (D.J.D., G.W.J., S.N., H.F.J.G., C. Chang., V.L.M., C. Constantinidis, D.J.E.)
bInstitute of Imaging Science (D.J.D., G.W.J., S.N., J.S.S., J.W.J., H.F.J.G., C. Chang, V.L.M., B.M.D., D.J.E.)
fVanderbilt Institute for Surgery and Engineering (D.J.D., G.W.J., S.N., H.F.J.G., C. Chang, V.L.M., B.M.D., D.J.E.), Nashville, Tennessee
gDepartments of Neurological Surgery (S.N., J.S.S., J.W.J., D.L.P., V.L.M., D.J.E.)
hNeurology (V.L.M.)
iRadiological Sciences (V.L.M., D.J.E.)
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C. Constantinidis
aFrom the Department of Biomedical Engineering (D.J.D., G.W.J., S.N., H.F.J.G., C. Chang., V.L.M., C. Constantinidis, D.J.E.)
eNeuroscience (C. Constantinidis), Vanderbilt University, Nashville, Tennessee
jOphthalmology and Visual Sciences (C. Constantinidis), Vanderbilt University Medical Center, Nashville, Tennessee
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B.M. Dawant
bInstitute of Imaging Science (D.J.D., G.W.J., S.N., J.S.S., J.W.J., H.F.J.G., C. Chang, V.L.M., B.M.D., D.J.E.)
cDepartments of Electrical and Computer Engineering (C. Chang, B.M.D., D.J.E.)
fVanderbilt Institute for Surgery and Engineering (D.J.D., G.W.J., S.N., H.F.J.G., C. Chang, V.L.M., B.M.D., D.J.E.), Nashville, Tennessee
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D.J. Englot
aFrom the Department of Biomedical Engineering (D.J.D., G.W.J., S.N., H.F.J.G., C. Chang., V.L.M., C. Constantinidis, D.J.E.)
bInstitute of Imaging Science (D.J.D., G.W.J., S.N., J.S.S., J.W.J., H.F.J.G., C. Chang, V.L.M., B.M.D., D.J.E.)
cDepartments of Electrical and Computer Engineering (C. Chang, B.M.D., D.J.E.)
fVanderbilt Institute for Surgery and Engineering (D.J.D., G.W.J., S.N., H.F.J.G., C. Chang, V.L.M., B.M.D., D.J.E.), Nashville, Tennessee
gDepartments of Neurological Surgery (S.N., J.S.S., J.W.J., D.L.P., V.L.M., D.J.E.)
iRadiological Sciences (V.L.M., D.J.E.)
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  • ORCID record for D.J. Englot
  • Article
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Article Information

DOI 
https://doi.org/10.3174/ajnr.A7950
PubMed 
37562826

Published By 
American Journal of Neuroradiology
Print ISSN 
0195-6108
Online ISSN 
1936-959X
History 
  • Received November 11, 2022
  • Accepted after revision June 25, 2023
  • Published online August 10, 2023.

Article Versions

  • You are currently viewing a Latest version of this article (August 10, 2023 - 08:52).
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Copyright & Usage 
© 2023 by American Journal of Neuroradiology Indicates open access to non-subscribers at www.ajnr.org

Author Information

  1. D.J. Dossa,b,f,
  2. G.W. Johnsona,b,f,
  3. S. Narasimhana,b,f,g,
  4. J.S. Shlessb,g,
  5. J.W. Jiangb,g,
  6. H.F.J. Gonzáleza,b,f,
  7. D.L. Paulog,
  8. A. Lucask,
  9. K.A. Davisl,m,n,
  10. C. Changa,b,c,d,f,
  11. V.L. Morgana,b,f,g,h,i,
  12. C. Constantinidisa,e,j,
  13. B.M. Dawantb,c,f and
  14. D.J. Englota,b,c,f,g,i
  1. aFrom the Department of Biomedical Engineering (D.J.D., G.W.J., S.N., H.F.J.G., C. Chang., V.L.M., C. Constantinidis, D.J.E.)
  2. bInstitute of Imaging Science (D.J.D., G.W.J., S.N., J.S.S., J.W.J., H.F.J.G., C. Chang, V.L.M., B.M.D., D.J.E.)
  3. cDepartments of Electrical and Computer Engineering (C. Chang, B.M.D., D.J.E.)
  4. dComputer Science (C. Chang)
  5. eNeuroscience (C. Constantinidis), Vanderbilt University, Nashville, Tennessee
  6. fVanderbilt Institute for Surgery and Engineering (D.J.D., G.W.J., S.N., H.F.J.G., C. Chang, V.L.M., B.M.D., D.J.E.), Nashville, Tennessee
  7. gDepartments of Neurological Surgery (S.N., J.S.S., J.W.J., D.L.P., V.L.M., D.J.E.)
  8. hNeurology (V.L.M.)
  9. iRadiological Sciences (V.L.M., D.J.E.)
  10. jOphthalmology and Visual Sciences (C. Constantinidis), Vanderbilt University Medical Center, Nashville, Tennessee
  11. kDepartments of Bioengineering (A.L.)
  12. lNeuroscience (K.A.D.)
  13. mCenter for Neuroengineering and Therapeutics (K.A.D.)
  14. nDepartment of Neurology (K.A.D.), University of Pennsylvania, Philadelphia, Pennsylvania
  1. Please address correspondence to Derek J. Doss, Vanderbilt University, 1500 21st Ave South, VAV 4340, Nashville, TN 37212; e-mail: derekjdoss{at}gmail.com; @DerekDoss
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Funding

  • National Institutes of Health

    F31NS106735; F31NS120401; R01NS108445; R01NS110130; R01NS112252; R01NS116504; T32EB001628-17; T32EB021937; T32GM007347

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Cite this article
D.J. Doss, G.W. Johnson, S. Narasimhan, J.S. Shless, J.W. Jiang, H.F.J. González, D.L. Paulo, A. Lucas, K.A. Davis, C. Chang, V.L. Morgan, C. Constantinidis, B.M. Dawant, D.J. Englot
Deep Learning Segmentation of the Nucleus Basalis of Meynert on 3T MRI
American Journal of Neuroradiology Aug 2023, DOI: 10.3174/ajnr.A7950

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Deep Learning Segmentation of the Nucleus Basalis of Meynert on 3T MRI
D.J. Doss, G.W. Johnson, S. Narasimhan, J.S. Shless, J.W. Jiang, H.F.J. González, D.L. Paulo, A. Lucas, K.A. Davis, C. Chang, V.L. Morgan, C. Constantinidis, B.M. Dawant, D.J. Englot
American Journal of Neuroradiology Aug 2023, DOI: 10.3174/ajnr.A7950
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This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Deep Learning–Based Algorithm for Automatic Quantification of Nigrosome-1 and Parkinsonism Classification Using Susceptibility Map–Weighted MRI
    Pae Sun Suh, Hwan Heo, Chong Hyun Suh, MyeongOh Lee, Soohwa Song, Donghoon Shin, Sungyang Jo, Sun Ju Chung, Hwon Heo, Woo Hyun Shim, Ho Sung Kim, Sang Joon Kim, Eung Yeop Kim
    American Journal of Neuroradiology 2025 46 5
  • Effects of strategic white matter hyperintensities of cholinergic pathways on basal forebrain volume in patients with amyloid-negative neurocognitive disorders
    Ye Eun Kim, Jae-Sung Lim, Chong Hyun Suh, Hwon Heo, Jee Hoon Roh, E-nae Cheong, Yoojin Lee, Jae Woo Kim, Jae-Hong Lee
    Alzheimer's Research & Therapy 2024 16 1
  • Network signatures define consciousness state during focal seizures
    Derek J. Doss, Graham W. Johnson, Ghassan S. Makhoul, Rohan V. Rashingkar, Jared S. Shless, Camden E. Bibro, Danika L. Paulo, Abhijeet Gummadavelli, Tyler J. Ball, Shilpa B. Reddy, Robert P. Naftel, Kevin F. Haas, Benoit M. Dawant, Christos Constantinidis, Shawniqua Williams Roberson, Sarah K. Bick, Victoria L. Morgan, Dario J. Englot
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  • An individualized tractography pipeline for the nucleus basalis of Meynert lateral tract
    Rachel A. Crockett, Kevin B. Wilkins, Michael M. Zeineh, Jennifer A. McNab, Jaimie M. Henderson, Vivek P. Buch, Helen M. Brontë-Stewart
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