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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Table of Contents

July 01, 2025; Volume 46,Issue 7

State of Practice

  • Health Policies/Quality Improvement/Evidence-Based Neuroimaging
    Open Access
    CPT Codes for MRI Safety—A User’s Guide
    Colin M. Segovis, Jacob W. Ormsby, Cindy X. Yuan, Matthew J. Goette, Melissa M. Chen and Heidi A. Edmonson
    American Journal of Neuroradiology July 2025, 46 (7) 1289-1291; DOI: https://doi.org/10.3174/ajnr.A8661

Review Articles

  • Artificial Intelligence
    Open Access
    A Review of the Opportunities and Challenges with Large Language Models in Radiology: The Road Ahead
    Neetu Soni, Manish Ora, Amit Agarwal, Tianbao Yang and Girish Bathla
    American Journal of Neuroradiology July 2025, 46 (7) 1292-1299; DOI: https://doi.org/10.3174/ajnr.A8589
  • Brain Tumor Imaging
    Open Access
    Neuroimaging Spectrum of Erdheim-Chester Disease: An Image-Based Review
    Pranjal Rai, Hayden J. Swartz, Neetu Soni, John C. Benson, Amit Agarwal, Steven A. Messina, Paul J. Farnsworth, Carrie M. Carr and Girish Bathla
    American Journal of Neuroradiology July 2025, 46 (7) 1300-1308; DOI: https://doi.org/10.3174/ajnr.A8599
  • Pediatric Neuroimaging
    Open Access
    Sodium MRI in Pediatric Brain Tumors
    Aashim Bhatia, Cassie Kline, Peter J. Madsen, Michael J. Fisher, Fernando E. Boada and Timothy P.L. Roberts
    American Journal of Neuroradiology July 2025, 46 (7) 1309-1317; DOI: https://doi.org/10.3174/ajnr.A8642

Radiology-Pathology Correlation

  • Head and Neck Imaging
    Open Access
    High-Resolution MR Imaging of the Parasellar Ligaments
    Ian T. Mark, Myung-Ho In, Daehun Kang, Eric Stinson, John Huston, Yunhong Shu, Luciano Leonel and Maria Peris Celda
    American Journal of Neuroradiology July 2025, 46 (7) 1318-1320; DOI: https://doi.org/10.3174/ajnr.A8658

General Contents

  • FELLOWS' JOURNAL CLUBNeurovascular/Stroke Imaging
    You have access
    Cracking the Code of Calcification: How Presence and Burden among Intracranial Arteries Influence Stroke Incidence and Recurrence
    Matteo Conte, Mohammed O. Alalfi, Riccardo Cau, Roberta Scicolone, Seemant Chaturvedi, Renu Virmani, Gianluca De Rubeis, Daniel Bos and Luca Saba
    American Journal of Neuroradiology July 2025, 46 (7) 1321-1328; DOI: https://doi.org/10.3174/ajnr.A8668

    This systematic review and meta-analysis analyzed published articles on intracranial arterial segments to understand the role of plaque calcification in stroke events. Weak association between intracranial calcification and stroke incidence/recurrence was found as well as weak association between calcium burden and stroke incidence/recurrence.

  • Neurovascular/Stroke Imaging
    You have access
    Location-Specific Net Water Uptake and Malignant Cerebral Edema in Acute Anterior Circulation Occlusion Ischemic Stroke
    XiaoQing Cheng, Bing Tian, LiJun Huang, Xi Shen, AnYu Liao, ChangSheng Zhou, Quan Hui Liu, HuiMin Pang, JinJing Tang, BaiYan Luo, Xia Tian, YuXi Hou, LuGuang Chen, Qian Chen, WuSheng Zhu, ChengWei Shao, XinDao Yin and GuangMing Lu
    American Journal of Neuroradiology July 2025, 46 (7) 1329-1335; DOI: https://doi.org/10.3174/ajnr.A8659
  • Neurovascular/Stroke Imaging
    You have access
    A Method for Imaging the Ischemic Penumbra with MRI Using Intravoxel Incoherent Motion
    Mira M. Liu, Niloufar Saadat, Steven P. Roth, Marek A. Niekrasz, Mihai Giurcanu, Mohammed Salman Shazeeb, Timothy J. Carroll and Gregory A. Christoforidis
    American Journal of Neuroradiology July 2025, 46 (7) 1336-1344; DOI: https://doi.org/10.3174/ajnr.A8656
  • Neurovascular/Stroke Imaging
    You have access
    Arterial Spin-Labeling MRI Identifies Abnormal Perfusion Metric at the Gray Matter/CSF Interface in Cerebral Small Vessel Disease
    Abdelkader Mahammedi, Ates Fettahoglu, Jeremy J. Heit, Joanna M. Wardlaw and Greg Zaharchuk
    American Journal of Neuroradiology July 2025, 46 (7) 1345-1352; DOI: https://doi.org/10.3174/ajnr.A8682
  • Neurovascular/Stroke Imaging
    You have access
    Correlation between P2-PCA Volume Flow Rate and BOLD Cerebrovascular Reactivity in Patients with Symptomatic Carotid Artery Occlusion
    Amely Walser, Jorn Fierstra, Lara Maria Höbner, Jacopo Bellomo, Tilman Schubert, Menno Germans, Vittorio Stumpo, Christiaan Hendrik Bas van Niftrik, Susanne Wegener, Andreas R. Luft, Zsolt Kulcsár, Luca Regli, Giuseppe Esposito and Martina Sebök
    American Journal of Neuroradiology July 2025, 46 (7) 1353-1359; DOI: https://doi.org/10.3174/ajnr.A8626
  • Neurovascular/Stroke Imaging
    You have access
    Quantitative Shape Irregularity and Density Heterogeneity of Preoperative Hematoma Can Predict Rebleeding following Minimally Invasive Catheter Evacuation for Intracerebral Hemorrhage
    Kaijiang Kang, Zeqiang Ji, Yang Du, Guangshuo Li, Jing Yan, Zeyu Ding, Yiming Shi, Yanfang Liu, Jianwei Wu and Xingquan Zhao
    American Journal of Neuroradiology July 2025, 46 (7) 1360-1366; DOI: https://doi.org/10.3174/ajnr.A8680
  • Neurovascular/Stroke Imaging
    You have access
    Circle of Willis Variants and Their Association with Outcome after Successful Revascularization of Anterior Large Vessel Occlusion
    Aakanksha Sriwastwa, Michael K. Oswald, Achala S. Vagal, Stacie L. Demel, Bin Zhang, Sriharsha Voleti, Arafat Ali, Daniel Morgan, Trevor Thompson, Johnathan Vidovich, Yasmin N. Aziz and Lily Li-Li Wang
    American Journal of Neuroradiology July 2025, 46 (7) 1367-1373; DOI: https://doi.org/10.3174/ajnr.A8643
  • Neurointervention
    You have access
    Effect of SARS-CoV-2 Infection on Endovascular Thrombectomy Outcomes—Data from the Florida Stroke Registry
    Hayes B. Fountain, Ian Ramsay, Ruijie Yin, Ahmed Abdelsalam, Michael Silva, David Z. Rose, Angus Jameson, Ying Hao, Ayham Alkhachroum, Carolina M. Gutierrez, Victor J. Del Brutto, Robert M. Starke, Tanja Rundek, Hannah Gardener, Jose G. Romano, Negar Asdaghi and for the Florida Stroke Registry
    American Journal of Neuroradiology July 2025, 46 (7) 1374-1378; DOI: https://doi.org/10.3174/ajnr.A8673
  • Neurointervention
    You have access
    Hydrogel Coils versus Bare Platinum Coils for the Treatment of Ruptured and Unruptured Aneurysms: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials
    Jonathan Cortese, Sherief Ghozy, Armin Zarrintan, Delal Bektas, Omar M. Al-Janabi, Onam Verma, Esref Alperen Bayraktar, Waleed Brinjikji, Ramanathan Kadirvel and David F. Kallmes
    American Journal of Neuroradiology July 2025, 46 (7) 1379-1386; DOI: https://doi.org/10.3174/ajnr.A8697
  • Neurointervention
    You have access
    Endovascular Treatment of Wide-Neck Intracranial Aneurysms Using the Novel Contour Neurovascular System: 5-Year Follow-up
    Howra Ktayen, Christopher Yusuf Akhunbay-Fudge, Atul Kumar Tyagi, Kenan Deniz and Tufail Patankar
    American Journal of Neuroradiology July 2025, 46 (7) 1387-1394; DOI: https://doi.org/10.3174/ajnr.A8641
  • Neurointervention
    You have access
    Safety and Effectiveness of a Novel Integrated Angiography System for Continuous Guidance and Flushing in Diagnostic Cerebral Catheter Angiography: A Randomized Controlled Trial
    Boseong Kwon, Jong-Tae Yoon, Yun Hyeok Choi, Soo Jeong, Byung Jun Kim, Joon Ho Choi, Sun Moon Hwang, Deok Hee Lee and Yunsun Song
    American Journal of Neuroradiology July 2025, 46 (7) 1395-1402; DOI: https://doi.org/10.3174/ajnr.A8700
  • Neurointervention
    You have access
    Reentry Technique for Rescue Recanalization of Carotid Near-Total Occlusion after Subintimal Penetration
    Dang Khoi Tran, Huu-Thao Nguyen, Chih-Wei Huang, Kai-Chen Chung and Yuang Seng Tsuei
    American Journal of Neuroradiology July 2025, 46 (7) 1403; DOI: https://doi.org/10.3174/ajnr.A8860
  • Artificial Intelligence
    You have access
    Improving the Robustness of Deep Learning Models in Predicting Hematoma Expansion from Admission Head CT
    Anh T. Tran, Gaby Abou Karam, Dorin Zeevi, Adnan I. Qureshi, Ajay Malhotra, Shahram Majidi, Santosh B. Murthy, Soojin Park, Despina Kontos, Guido J. Falcone, Kevin N. Sheth and Seyedmehdi Payabvash
    American Journal of Neuroradiology July 2025, 46 (7) 1404-1411; DOI: https://doi.org/10.3174/ajnr.A8650
  • Artificial Intelligence
    You have access
    Deep Learning MRI Models for the Differential Diagnosis of Tumefactive Demyelination versus IDH Wild-Type Glioblastoma
    Gian Marco Conte, Mana Moassefi, Paul A. Decker, Matthew L. Kosel, Christina B. McCarthy, Jessica A. Sagen, Yalda Nikanpour, Mahboubeh Fereidan-Esfahani, Michael W. Ruff, Fiorella S. Guido, Heather K. Pump, Terry C. Burns, Robert B. Jenkins, Bradley J. Erickson, Daniel H. Lachance, W. Oliver Tobin and Jeanette E. Eckel-Passow
    American Journal of Neuroradiology July 2025, 46 (7) 1412-1420; DOI: https://doi.org/10.3174/ajnr.A8645
  • Brain Tumor Imaging
    You have access
    Image-Based Search in Radiology: Identification of Brain Tumor Subtypes within Databases Using MRI-Based Radiomic Features
    Marc von Reppert, Saahil Chadha, Klara Willms, Arman Avesta, Nazanin Maleki, Tal Zeevi, Jan Lost, Niklas Tillmanns, Leon Jekel, Sara Merkaj, MingDe Lin, Karl-Titus Hoffmann, Sanjay Aneja, Mariam S. Aboian and for the IBSR Consortium
    American Journal of Neuroradiology July 2025, 46 (7) 1421-1428; DOI: https://doi.org/10.3174/ajnr.A8805
  • Neurodegenerative Disorder Imaging
    You have access
    The Value of Quantitative Susceptibility Mapping and Morphometry in the Differential Diagnosis of Parkinsonism
    Yi Li, Tingting Yuan, Lulu Gao, Wei Sun, Xiaoxiao Du, Zhihui Sun, Kangli Fan, Ruqing Qiu and Ying Zhang
    American Journal of Neuroradiology July 2025, 46 (7) 1429-1438; DOI: https://doi.org/10.3174/ajnr.A8665
  • EDITOR'S CHOICENeurodegenerative Disorder Imaging
    You have access
    Antiamyloid Therapy and Cerebral Blood Flow Changes on MRI: A Potential Longitudinal Biomarker of Treatment Response?
    Andres Ricaurte-Fajardo, Jana Ivanidze, Deborah Zhang, Meem Mahmud, Weiye Yasen, Lisa Ravdin, Silky Pahlajani, Mony de Leon, Anna S. Nordvig and Gloria C. Chiang
    American Journal of Neuroradiology July 2025, 46 (7) 1439-1445; DOI: https://doi.org/10.3174/ajnr.A8654

    AD is characterized by the accumulation of extracellular amyloid-β in the brain parenchyma and along the walls of cerebral blood vessels, leading to decreased CBF. CBF changes on ASL-MR could reflect clearance of amyloid-β on lecanemab therapy, raising the possibility that ASL-MR could serve as a tool for monitoring the neurovascular treatment response.

  • EDITOR'S CHOICEHead and Neck Imaging
    You have access
    Deep Invasion Volume of the Primary Nasopharyngeal Carcinoma Predicts Treatment Outcome
    Qi Yong H. Ai, Ho Sang Leung, Frankie K.F. Mo, Lun M. Wong, Linfang Lan, Edwin P. Hui, Brigette B.Y. Ma and Ann D. King
    American Journal of Neuroradiology July 2025, 46 (7) 1446-1452; DOI: https://doi.org/10.3174/ajnr.A8678

    The results of this study on quantification of deep invasion of NPC showed that the tumors with a relatively large deep component compared with the superficial component had a poorer outcome. Specifically, volume of deep invasion in primary NPC (ratio of deep to the total primary tumor volume) was found to correlate with the presence of nodal metastases and the best predictor of outcome, especially distant metastases-free survival.

  • Head and Neck Imaging
    You have access
    Peritumoral Hyperintense Signal on Postcontrast FLAIR Images Surrounding Vestibular Schwannomas following Stereotactic Radiosurgery
    Sandy T. Nguyen, John C. Benson, Girish Bathla, Paul J. Farnsworth, Matthew L. Carlson, Michael J. Link and John I. Lane
    American Journal of Neuroradiology July 2025, 46 (7) 1453-1457; DOI: https://doi.org/10.3174/ajnr.A8657
  • Head and Neck Imaging
    You have access
    The Sensitivity of Arterial Spin-Labeling Imaging for Detection of Head and Neck Paragangliomas
    Yannan Yu, Brian Q. Tsui, Christine M. Glastonbury and Xin (Cynthia) Wu
    American Journal of Neuroradiology July 2025, 46 (7) 1458-1463; DOI: https://doi.org/10.3174/ajnr.A8727
  • Pediatric Neuroimaging
    You have access
    Perfusion Showdown: Comparison of Multiple MRI Perfusion Techniques in the Grading of Pediatric Brain Tumors
    Chang Y. Ho, Nucharin Supakul, Greg Anthony, Qiuting Wen, Paula Chen, Maryann Allen, Jason G. Parker, Benjamin R. Gray, Eric Chen, Paul R. Territo, Scott A. Persohn, Stephen F. Kralik and Gary D. Hutchins
    American Journal of Neuroradiology July 2025, 46 (7) 1464-1470; DOI: https://doi.org/10.3174/ajnr.A8635
  • EDITOR'S CHOICEPediatric Neuroimaging
    You have access
    Comparing CT-Like Bone Images Based on Fast Field Echo Resembling a CT Using Restricted Echo Spacing (FRACTURE) MR with CT in Pediatric Congenital Vertebral Anomalies
    Hirva Manek and Foram Gala
    American Journal of Neuroradiology July 2025, 46 (7) 1471-1477; DOI: https://doi.org/10.3174/ajnr.A8639

    FRACTURE MR is reliable for bone imaging in pediatric complex spinal anomalies and can be complementary to conventional MR in providing osseous details, reducing the need for additional study, and avoiding radiation. The bone signal and cortical trabecular differentiation are excellent in older children (>3 years old).

  • FELLOWS' JOURNAL CLUBSpine Imaging and Spine Image-Guided Interventions
    You have access
    Management Outcomes after Image-Guided Percutaneous Biopsy for Suspected Vertebral Osteomyelitis-Discitis
    Dania G. Malik, Mathew V. Smith, Gabriel M. Swenson, Robert E. Grady, Felix E. Diehn, Erik H. Middlebrooks, Jeffrey S. Ross and Tanya J. Rath
    American Journal of Neuroradiology July 2025, 46 (7) 1478-1485; DOI: https://doi.org/10.3174/ajnr.A8630

    This retrospective study of patients who underwent image-guided biopsy for suspected vertebral osteomyelitis-discitis aimed to assess how biopsy results impact clinical management. It was found that biopsy results changed management in 36% of cases, mostly in culture-positive cases allowing for customizing antibiotic treatment. While antibiotic therapy at the time of biopsy did not impact yield, it was concluded that it may lead to less management change.

  • Spine Imaging and Spine Image-Guided Interventions
    You have access
    Prevalence and Characteristics of Microspurs in Patients with Spontaneous Intracranial Hypotension Compared with the General Population
    Danial Nasiri, Levin Häni, Johannes Goldberg, Thomas Petutschnigg, Tomas Dobrocky, Ralph T. Schär, Christoph Schankin, Andreas Raabe, Jürgen Beck, Eike Immo Piechowiak and Christopher Marvin Jesse
    American Journal of Neuroradiology July 2025, 46 (7) 1486-1492; DOI: https://doi.org/10.3174/ajnr.A8644
  • Molecular Neuroimaging/Nuclear Medicine
    You have access
    Fusion of FDG and FMZ PET Reduces False-Positives in Predicting Epileptogenic Zone
    Bingyang Cai, Shize Jiang, Hui Huang, Jiwei Li, Siyu Yuan, Ya Cui, Weiqi Bao, Jie Hu, Jie Luo and Liang Chen
    American Journal of Neuroradiology July 2025, 46 (7) 1493-1500; DOI: https://doi.org/10.3174/ajnr.A8647
  • FELLOWS' JOURNAL CLUBUltra-High-Field MRI/Imaging of Epilepsy/Demyelinating Diseases/Inflammation/Infection
    You have access
    MRI Interpretation Errors in Adult Patients with Medically Refractory Epilepsy
    Aoife M. Haughey, Nadav Gasner and Timo Krings
    American Journal of Neuroradiology July 2025, 46 (7) 1501-1509; DOI: https://doi.org/10.3174/ajnr.A8681

    This retrospective observational study highlights common diagnostic pitfalls in epilepsy MRI interpretation, with MTS, FCD, and enlarged amygdala being the most frequently missed pathologies. It highlights the importance of combining clinical information and EEG findings to enhance diagnostic accuracy.

  • Ultra-High-Field MRI/Imaging of Epilepsy/Demyelinating Diseases/Inflammation/Infection
    You have access
    Cross-Sectional Validation of an Automated Lesion Segmentation Software in Multiple Sclerosis: Comparison with Radiologist Assessments
    Maria Vittoria Spampinato, Heather R. Collins, Hannah Wells, William Dennis, Jordan H. Chamberlin, Emily Ye, Justin A. Chetta, Maria Gisele Matheus, Seth T. Stalcup and Donna R. Roberts
    American Journal of Neuroradiology July 2025, 46 (7) 1510-1516; DOI: https://doi.org/10.3174/ajnr.A8655
  • Ultra-High-Field MRI/Imaging of Epilepsy/Demyelinating Diseases/Inflammation/Infection
    You have access
    Application of Deep Learning Accelerated Image Reconstruction in T2-Weighted Turbo Spin-Echo Imaging of the Brain at 7T
    Zeyu Liu, Xiangzhi Zhou, Shengzhen Tao, Jun Ma, Dominik Nickel, Patrick Liebig, Mahmoud Mostapha, Vishal Patel, Erin M. Westerhold, Hamed Mojahed, Vivek Gupta and Erik H. Middlebrooks
    American Journal of Neuroradiology July 2025, 46 (7) 1517-1520; DOI: https://doi.org/10.3174/ajnr.A8662
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American Journal of Neuroradiology: 46 (7)
American Journal of Neuroradiology
Vol. 46, Issue 7
1 Jul 2025
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Print ISSN: 0195-6108 Online ISSN: 1936-959X

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