Article Figures & Data
Figures
- FIG 1.
Pipeline for generation of a single-subject lesion connectivity map and lesion tract map (A and B). The lesion is segmented from the posttreatment MR imaging (C). The mean BOLD time-series for the lesion is extracted and correlated to all other brain voxels. D, The resulting t-score map is a patient-specific lesion connectivity map. E, The lesion is used as a seed region to generate a patient-specific lesion tract map representing the probability of all streamlines connected to the lesion.
- FIG 2.
Tract fingerprint representing the ideal tract connectivity pattern for tremor improvement. Commonly implicated areas of abnormality in tremor are identified, including the cerebello-thalamo-cortical motor network, as well as striate and extrastriate cortical regions.
- FIG 3.
Group tract R-map of pathways most correlated with tremor improvement.
- FIG 4.
A, Leave-one-out cross-validation of the tract fingerprint shows greater similarity of the individual’s lesion tract map to the fingerprint map predicted measured improvement in tremor (r = 0.52; P = .006). B, Leave-one-out cross-validation of the functional fingerprint also shows that greater similarity of the individual’s lesion functional map to the fingerprint map predicted measured improvement in tremor (r = 0.50; P = .008).
- FIG 5.
Functional fingerprint representing the ideal tract connectivity pattern for tremor improvement. Similar to the tract fingerprint, commonly implicated areas of abnormality in tremor are identified, including the cerebello-thalamo-cortical motor network as well as the striate and extrastriate cortical regions.
Tables
Demographic and clinical outcome data
Criteria Age at treatment (yr) 72.3 (SD, 13.1) Male sex (No.) (%) 17 (63.0%) Essential tremor (No.) (%) 22 (81.5%) Parkinson disease (No.) (%) 4 (14.8%) ET + PD (No.) (%) 1 (3.7%) Baseline contralateral TRS score (mean) 6.8 (SD, 4.3) Baseline ipsilateral TRS score (mean) 4.9 (SD, 4.3) Baseline midline TRS score (mean) 2.5 (SD, 2.8) Follow-up duration (mean) (mo) 10.0 (SD, 5.0) Postoperative contralateral TRS improvement (mean) 55.1% (SD, 38.9%) Postoperative ipsilateral TRS improvement (mean) 9.9% (SD, 61.8%) Postoperative midline TRS improvement (mean) 27.2% (SD, 90.0%) Note:—ET indicates essential tremor; PD, Parkinson disease.
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