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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleAdult Brain
Open Access

Manganese-Enhanced MRI in Patients with Multiple Sclerosis

D.J. Suto, G. Nair, D.M. Sudarshana, S.U. Steele, J. Dwyer, E.S. Beck, J. Ohayon, H. McFarland, A.P. Koretsky, I.C.M. Cortese and D.S. Reich
American Journal of Neuroradiology September 2020, 41 (9) 1569-1576; DOI: https://doi.org/10.3174/ajnr.A6665
D.J. Suto
aFrom the National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland.
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G. Nair
aFrom the National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland.
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D.M. Sudarshana
aFrom the National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland.
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S.U. Steele
aFrom the National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland.
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J. Dwyer
aFrom the National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland.
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E.S. Beck
aFrom the National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland.
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J. Ohayon
aFrom the National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland.
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H. McFarland
aFrom the National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland.
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A.P. Koretsky
aFrom the National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland.
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I.C.M. Cortese
aFrom the National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland.
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D.S. Reich
aFrom the National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland.
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References

  1. 1.↵
    1. Reich DS,
    2. Lucchinetti CF,
    3. Calabresi PA
    . Multiple sclerosis. N Engl J Med 2018;378:169–80 doi:10.1056/NEJMra1401483 pmid:29320652
    CrossRefPubMed
  2. 2.↵
    1. Filippi M,
    2. Rocca MA,
    3. Barkhof F, et al
    ; Attendees of the Correlation between Pathological MRI Findings in MS Workshop. Association between pathological and MRI findings in multiple sclerosis. Lancet Neurol 2012;11:349–60 doi:10.1016/S1474-4422(12)70003-0 pmid:30663609
    CrossRefPubMedWeb of Science
  3. 3.↵
    1. Absinta M,
    2. Sati P,
    3. Reich DS
    . Advanced MRI and staging of multiple sclerosis lesions. Nat Rev Neurol 2016;12:358–68 doi:10.1038/nrneurol.2016.59 pmid:27125632
    CrossRefPubMed
  4. 4.↵
    1. Henderson AP,
    2. Barnett MH,
    3. Parratt JD, et al
    . Multiple sclerosis: distribution of inflammatory cells in newly forming lesions. Ann Neurol 2009;66:739–53 doi:10.1002/ana.21800 pmid:20035511
    CrossRefPubMedWeb of Science
  5. 5.↵
    1. Silva AC,
    2. Bock NA
    . Manganese-enhanced MRI: an exceptional tool in translational neuroimaging. Schizophr Bull 2008;34:595–604 doi:10.1093/schbul/sbn056 pmid:18550591
    CrossRefPubMedWeb of Science
  6. 6.↵
    1. Stieltjes B,
    2. Schlüter M,
    3. Didinger B, et al
    . Diffusion tensor imaging in primary brain tumors: reproducible quantitative analysis of corpus callosum infiltration and contralateral involvement using a probabilistic mixture model. Neuroimage 2006;31:531–42 doi:10.1016/j.neuroimage.2005.12.052 pmid:16478665
    CrossRefPubMed
  7. 7.
    1. Walder N,
    2. Petter-Puchner AH,
    3. Brejnikow M, et al
    . Manganese enhanced magnetic resonance imaging in a contusion model of spinal cord injury in rats: correlation with motor function. Invest Radiol 2008;43:277–83 doi:10.1097/RLI.0b013e318162f1bd pmid:18424947
    CrossRefPubMedWeb of Science
  8. 8.
    1. Lee JH,
    2. Silva AC,
    3. Merkle H, et al
    . Manganese-enhanced magnetic resonance imaging of mouse brain after systemic administration of MnCl2: dose-dependent and temporal evolution of T1 contrast. Magn Reson Med 2005;53:640–48 doi:10.1002/mrm.20368 pmid:15723400
    CrossRefPubMedWeb of Science
  9. 9.
    1. Monosov IE,
    2. Leopold DA,
    3. Hikosaka O
    . Neurons in the primate medial basal forebrain signal combined information about reward uncertainty, value, and punishment anticipation. J Neurosci 2015;35:7443–59 doi:10.1523/JNEUROSCI.0051-15.2015 pmid:25972172
    Abstract/FREE Full Text
  10. 10.↵
    1. Van Meir V,
    2. Pavlova D,
    3. Verhoye M, et al
    . In vivo MR imaging of the seasonal volumetric and functional plasticity of song control nuclei in relation to song output in a female songbird. Neuroimage 2006;31:981–92 doi:10.1016/j.neuroimage.2006.01.005 pmid:16529952
    CrossRefPubMedWeb of Science
  11. 11.↵
    1. Crossgrove J,
    2. Zheng W
    . Manganese toxicity upon overexposure. NMR Biomed 2004;17:544–53 doi:10.1002/nbm.931 pmid:15617053
    CrossRefPubMedWeb of Science
  12. 12.↵
    1. Toft KG,
    2. Hustvedt SO,
    3. Grant D, et al
    . Metabolism and pharmacokinetics of MnDPDP in man. Acta Radiol 1997;38(4 Pt 2):677–89 doi:10.1080/02841859709172400 pmid:9245963
    CrossRefPubMedWeb of Science
  13. 13.↵
    1. Sudarshana DM,
    2. Nair G,
    3. Dwyer JT, et al
    . Manganese-enhanced MRI of the brain in healthy volunteers. AJNR Am J Neuroradiol 2019;40:1309–16 doi:10.3174/ajnr.A6152 pmid:31371354
    Abstract/FREE Full Text
  14. 14.↵
    1. Aoki I,
    2. Wu YJ,
    3. Silva AC, et al
    . In vivo detection of neuroarchitecture in the rodent brain using manganese-enhanced MRI. Neuroimage 2004;22:1046–59 doi:10.1016/j.neuroimage.2004.03.031 pmid:15219577
    CrossRefPubMedWeb of Science
  15. 15.↵
    1. Tustison NJ,
    2. Avants BB,
    3. Cook PA, et al
    . N4ITK: improved N3 Bias correction. IEEE Trans Med Imaging 2010;29:1310–20 doi:10.1109/TMI.2010.2046908 pmid:20378467
    CrossRefPubMedWeb of Science
  16. 16.↵
    1. Nakamura K,
    2. Brown RA,
    3. Narayanan S, et al
    . Diurnal fluctuations in brain volume: statistical analyses of MRI from large populations. Neuroimage 2015;118:126–32 doi:10.1016/j.neuroimage.2015.05.077 pmid:26049148
    CrossRefPubMed
  17. 17.↵
    1. Absinta M,
    2. Nair G,
    3. Sati P, et al
    . Direct MRI detection of impending plaque development in multiple sclerosis. Neurol Neuroimmunol Neuroinflamm 2015;2:e145 doi:10.1212/NXI.0000000000000145 pmid:26401516
    Abstract/FREE Full Text
  18. 18.↵
    1. Goodkin DE,
    2. Rooney WD,
    3. Sloan R, et al
    . A serial study of new MS lesions and the white matter from which they arise. Neurology 1998;51:1689–97 doi:10.1212/wnl.51.6.1689 pmid:9855524
    Abstract/FREE Full Text
  19. 19.↵
    1. Maggi P,
    2. Macri SM,
    3. Gaitán MI, et al
    . The formation of inflammatory demyelinated lesions in cerebral white matter. Ann Neurol 2014;76:594–608 doi:10.1002/ana.24242 pmid:30687321
    CrossRefPubMed
  20. 20.↵
    1. Pautler RG
    . In vivo, trans-synaptic tract-tracing utilizing manganese-enhanced magnetic resonance imaging (MEMRI). NMR Biomed 2004;17:595–601 doi:10.1002/nbm.942 pmid:15761948
    CrossRefPubMedWeb of Science
  21. 21.↵
    1. Saleem KS,
    2. Pauls JM,
    3. Augath M, et al
    . Magnetic resonance imaging of neuronal connections in the macaque monkey. Neuron 2002;34:685–700 doi:10.1016/s0896-6273(02)00718-3 pmid:12062017
    CrossRefPubMedWeb of Science
  22. 22.↵
    1. Chuang KH,
    2. Lee JH,
    3. Silva AC, et al
    . Manganese enhanced MRI reveals functional circuitry in response to odorant stimuli. Neuroimage 2009;44:363–72 doi:10.1016/j.neuroimage.2008.08.046 pmid:18848997
    CrossRefPubMedWeb of Science
  23. 23.↵
    1. Wolf GL,
    2. Baum L
    . Cardiovascular toxicity and tissue proton T1 response to manganese injection in the dog and rabbit. AJR Am J Roentgenol 1983;141:193–97 doi:10.2214/ajr.141.1.193 pmid:6305179
    CrossRefPubMedWeb of Science
  24. 24.↵
    1. Saar G,
    2. Millo C,
    3. Szajek L, et al
    . Anatomy, functionality, and neuronal connectivity with manganese radiotracers for positron emission tomography. Mol Imaging Biol 2018;20:562–74 doi:10.1007/s11307-018-1162-6 pmid:29396750
    CrossRefPubMed
  25. 25.↵
    1. Kim HJ,
    2. Kim KW,
    3. Byun JH, et al
    . Comparison of mangafodipir trisodium- and ferucarbotran-enhanced MRI for detection and characterization of hepatic metastases in colorectal cancer patients. AJR Am J Roentgenol 2006;186:1059–66 doi:10.2214/AJR.04.1941 pmid:16554579
    CrossRefPubMed
  26. 26.↵
    1. Oudkerk M,
    2. Torres CG,
    3. Song B, et al
    . Characterization of liver lesions with mangafodipir trisodium-enhanced MR imaging: multicenter study comparing MR and dual-phase spiral CT. Radiology 2002;223:517–24 doi:10.1148/radiol.2232010318 pmid:11997562
    CrossRefPubMed
  27. 27.↵
    1. Choi JY,
    2. Kim MJ,
    3. Kim JH, et al
    . Detection of hepatic metastasis: manganese- and ferucarbotran-enhanced MR imaging (in French). Eur J Radiol 2006;60:84–90 doi:10.1016/j.ejrad.2006.06.016 pmid:16920315
    CrossRefPubMed
  28. 28.↵
    1. Beziat C,
    2. Pilleul F,
    3. Yzebe D, et al
    . Detection of liver metastases in colorectal cancer on chemotherapy: comparative study between MRI with Teslascan and computed tomography with intravenous contrast media. J Radiol 2004;85:307–11 doi:10.1016/S0221-0363(04)97583-X pmid:15192523
    CrossRefPubMed
  29. 29.↵
    1. Sutcliffe RP,
    2. Lewis D,
    3. Kane PA, et al
    . Manganese-enhanced MRI predicts the histological grade of hepatocellular carcinoma in potential surgical candidates. Clin Radiol 2011;66:237–43 doi:10.1016/j.crad.2010.08.007 pmid:21295202
    CrossRefPubMed
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D.J. Suto, G. Nair, D.M. Sudarshana, S.U. Steele, J. Dwyer, E.S. Beck, J. Ohayon, H. McFarland, A.P. Koretsky, I.C.M. Cortese, D.S. Reich
Manganese-Enhanced MRI in Patients with Multiple Sclerosis
American Journal of Neuroradiology Sep 2020, 41 (9) 1569-1576; DOI: 10.3174/ajnr.A6665

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Manganese-Enhanced MRI in Patients with Multiple Sclerosis
D.J. Suto, G. Nair, D.M. Sudarshana, S.U. Steele, J. Dwyer, E.S. Beck, J. Ohayon, H. McFarland, A.P. Koretsky, I.C.M. Cortese, D.S. Reich
American Journal of Neuroradiology Sep 2020, 41 (9) 1569-1576; DOI: 10.3174/ajnr.A6665
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