Article Figures & Data
Figures
- Fig 1.
ROI placements. Four to six ROIs were drawn in both intratumoral (circle with solid line) and peritumoral (circle with dotted line) regions, and the maximum value was recorded. Also, an ROI in the contralateral white matter (circle with dotted line) was chosen as a reference. The insert is the magnification of lesion area.
- Fig 2.
iVASO-CBVa, rCBVa, and DSC-rCBV in the intratumoral region (A) and in peritumoral T2-hyperintense region (B) of glioblastoma and single brain metastasis. Data are presented as mean value ± SD. Ns indicates not significant.
- Fig 3.
Representative MR images of glioblastoma and single brain metastasis. Upper row, A GBM in a 51-year-old woman. Lower row, SBM in a 46-year-old man. Both GBM and SBM present as hyperintense masses on T2 FLAIR with extensive peritumoral edema (A and E) and show a ring-enhancement pattern on fat-suppressed postcontrast T1WI with prominent necrosis in the tumor center (B and F). In intratumoral regions, GBM shows maximum DSC-rCBV similar to that of SBM (5.29 versus 4.98, arrows in C and G), but higher maximum iVASO-CBVa than SBM (5.90/100 mL versus 1.30/100 mL, arrows in D and H). In the peritumoral region, GBM shows prominently higher DSC-rCBV and iVASO-CBVa than SBM (DSC-rCBV, 3.11 versus 1.25, arrowheads in C and G; iVASO-CBVa, 1.20/100 mL versus 0.55/100 mL, arrowheads in D and H).
- Fig 4.
Receiver operating characteristic curves of parameters of iVASO and DSC MR imaging in differentiating glioblastoma and solitary brain metastasis. In the intratumoral region (A), both iVASO-CBVa (AUC = 0.91) and rCBVa (AUC = 0.90) show higher AUCs than DSC-rCBV (AUC = 0.51). In the PTH (B), the AUC of DSC-rCBV (0.94) is higher than that of iVASO-CBVa (0.83) or rCBVa (0.72).
Tables
Results of receiver operating characteristic analysis of each parameter
Technique/Parameter AUC P Value Cutoff Se (%) Sp (%) Intratumoral region iVASO CBVa 0.91 <.001 3.25 80.0 100.0 rCBVa 0.90 <.001 5.28 70.0 100.0 DSC rCBV 0.51 .920 3.11 100.0 18.2 Peritumoral region iVASO CBVa 0.83 <.001 1.03 80.0 77.3 rCBVa 0.72 .014 2.04 55.0 95.5 DSC rCBV 0.94 <.001 2.26 80.0 100.0 Note: Se indicates sensitivity; Sp, specificity.
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