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Research ArticleADULT BRAIN
Open Access

Iron-Insensitive Quantitative Assessment of Subcortical Gray Matter Demyelination in Multiple Sclerosis Using the Macromolecular Proton Fraction

V.L. Yarnykh, E.P. Krutenkova, G. Aitmagambetova, P. Repovic, A. Mayadev, P. Qian, L.K. Jung Henson, B. Gangadharan and J.D. Bowen
American Journal of Neuroradiology April 2018, 39 (4) 618-625; DOI: https://doi.org/10.3174/ajnr.A5542
V.L. Yarnykh
aFrom the Department of Radiology (V.L.Y.), University of Washington, Seattle, Washington
bResearch Institute of Biology and Biophysics (E.P.K., G.A., V.L.Y.), Tomsk State University, Tomsk, Russian Federation
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  • ORCID record for V.L. Yarnykh
E.P. Krutenkova
bResearch Institute of Biology and Biophysics (E.P.K., G.A., V.L.Y.), Tomsk State University, Tomsk, Russian Federation
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G. Aitmagambetova
bResearch Institute of Biology and Biophysics (E.P.K., G.A., V.L.Y.), Tomsk State University, Tomsk, Russian Federation
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P. Repovic
cMultiple Sclerosis Center (P.R., A.M., P.Q., L.K.J.H., B.G., J.D.B.), Swedish Neuroscience Institute, Seattle, Washington
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A. Mayadev
cMultiple Sclerosis Center (P.R., A.M., P.Q., L.K.J.H., B.G., J.D.B.), Swedish Neuroscience Institute, Seattle, Washington
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P. Qian
cMultiple Sclerosis Center (P.R., A.M., P.Q., L.K.J.H., B.G., J.D.B.), Swedish Neuroscience Institute, Seattle, Washington
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L.K. Jung Henson
cMultiple Sclerosis Center (P.R., A.M., P.Q., L.K.J.H., B.G., J.D.B.), Swedish Neuroscience Institute, Seattle, Washington
dPiedmont Henry Hospital (L.K.J.H.), Stockbridge, Georgia.
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B. Gangadharan
cMultiple Sclerosis Center (P.R., A.M., P.Q., L.K.J.H., B.G., J.D.B.), Swedish Neuroscience Institute, Seattle, Washington
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J.D. Bowen
cMultiple Sclerosis Center (P.R., A.M., P.Q., L.K.J.H., B.G., J.D.B.), Swedish Neuroscience Institute, Seattle, Washington
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Article Information

vol. 39 no. 4 618-625
DOI 
https://doi.org/10.3174/ajnr.A5542
PubMed 
29439122

Published By 
American Journal of Neuroradiology
Print ISSN 
0195-6108
Online ISSN 
1936-959X
History 
  • Received September 29, 2017
  • Accepted after revision November 28, 2017
  • Published online April 10, 2018.

Article Versions

  • Latest version (February 8, 2018 - 06:53).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2018 by American Journal of Neuroradiology Indicates open access to non-subscribers at www.ajnr.org

Author Information

  1. V.L. Yarnykha,b,
  2. E.P. Krutenkovab,
  3. G. Aitmagambetovab,
  4. P. Repovicc,
  5. A. Mayadevc,
  6. P. Qianc,
  7. L.K. Jung Hensonc,d,
  8. B. Gangadharanc and
  9. J.D. Bowenc
  1. aFrom the Department of Radiology (V.L.Y.), University of Washington, Seattle, Washington
  2. bResearch Institute of Biology and Biophysics (E.P.K., G.A., V.L.Y.), Tomsk State University, Tomsk, Russian Federation
  3. cMultiple Sclerosis Center (P.R., A.M., P.Q., L.K.J.H., B.G., J.D.B.), Swedish Neuroscience Institute, Seattle, Washington
  4. dPiedmont Henry Hospital (L.K.J.H.), Stockbridge, Georgia.
  1. Please address correspondence to Vasily L. Yarnykh, PhD, Department of Radiology, University of Washington, 850 Republican St, Room 255, Seattle, WA 98109; e-mail: yarnykh{at}uw.edu; @yarnykh
View Full Text

Funding

  • National Multiple Sclerosis Society

    RG 4864A1/1
  • National Institute of Biomedical Imaging and Bioengineering

    R21EB009908
  • Ministry of Education and Science of the Russian Federation

    State Assignment Project No. 18.2583.2017/4.6.

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V.L. Yarnykh, E.P. Krutenkova, G. Aitmagambetova, P. Repovic, A. Mayadev, P. Qian, L.K. Jung Henson, B. Gangadharan, J.D. Bowen
Iron-Insensitive Quantitative Assessment of Subcortical Gray Matter Demyelination in Multiple Sclerosis Using the Macromolecular Proton Fraction
American Journal of Neuroradiology Apr 2018, 39 (4) 618-625; DOI: 10.3174/ajnr.A5542

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Iron-Insensitive Quantitative Assessment of Subcortical Gray Matter Demyelination in Multiple Sclerosis Using the Macromolecular Proton Fraction
V.L. Yarnykh, E.P. Krutenkova, G. Aitmagambetova, P. Repovic, A. Mayadev, P. Qian, L.K. Jung Henson, B. Gangadharan, J.D. Bowen
American Journal of Neuroradiology Apr 2018, 39 (4) 618-625; DOI: 10.3174/ajnr.A5542
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Cited By...

  • Assessment of Trigeminal Nerve Root Demyelination in Patients with Primary Trigeminal Neuralgia Using Macromolecular Proton Fraction Imaging
  • Crossref (30)
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This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Cerebral Iron Deposition in Neurodegeneration
    Petr Dusek, Tim Hofer, Jan Alexander, Per M. Roos, Jan O. Aaseth
    Biomolecules 2022 12 5
  • Deep grey matter injury in multiple sclerosis: a NAIMS consensus statement
    Daniel Ontaneda, Praneeta C Raza, Kedar R Mahajan, Douglas L Arnold, Michael G Dwyer, Susan A Gauthier, Douglas N Greve, Daniel M Harrison, Roland G Henry, David K B Li, Caterina Mainero, Wayne Moore, Sridar Narayanan, Jiwon Oh, Raihaan Patel, Daniel Pelletier, Alexander Rauscher, William D Rooney, Nancy L Sicotte, Roger Tam, Daniel S Reich, Christina J Azevedo
    Brain 2021 144 7
  • Myelin development in cerebral gray and white matter during adolescence and late childhood
    Neva M. Corrigan, Vasily L. Yarnykh, Daniel S. Hippe, Julia P. Owen, Elizabeth Huber, T. Christina Zhao, Patricia K. Kuhl
    NeuroImage 2021 227
  • Quantitative Imaging of White and Gray Matter Remyelination in the Cuprizone Demyelination Model Using the Macromolecular Proton Fraction
    Marina Khodanovich, Anna Pishchelko, Valentina Glazacheva, Edgar Pan, Andrey Akulov, Mikhail Svetlik, Yana Tyumentseva, Tatyana Anan’ina, Vasily Yarnykh
    Cells 2019 8 10
  • Direct comparison between apparent diffusion coefficient and macromolecular proton fraction as quantitative biomarkers of the human fetal brain maturation
    Alexandra M. Korostyshevskaya, Irina Yu. Prihod'ko, Andrey A. Savelov, Vasily L. Yarnykh
    Journal of Magnetic Resonance Imaging 2019 50 1
  • Global hypomyelination of the brain white and gray matter in schizophrenia: quantitative imaging using macromolecular proton fraction
    Liudmila P. Smirnova, Vasily L. Yarnykh, Daria A. Parshukova, Elena G. Kornetova, Arkadiy V. Semke, Anna V. Usova, Anna O. Pishchelko, Marina Y. Khodanovich, Svetlana A. Ivanova
    Translational Psychiatry 2021 11 1
  • Macromolecular Proton Fraction as a Myelin Biomarker: Principles, Validation, and Applications
    Alena A. Kisel, Anna V. Naumova, Vasily L. Yarnykh
    Frontiers in Neuroscience 2022 16
  • Scan–Rescan Repeatability and Impact of B0 and B1 Field Nonuniformity Corrections in Single‐Point Whole‐Brain Macromolecular Proton Fraction Mapping
    Vasily L. Yarnykh, Alena A. Kisel, Marina Y. Khodanovich
    Journal of Magnetic Resonance Imaging 2020 51 6
  • Role of Demyelination in the Persistence of Neurological and Mental Impairments after COVID-19
    Marina Y. Khodanovich, Daria A. Kamaeva, Anna V. Naumova
    International Journal of Molecular Sciences 2022 23 19
  • Long-term monitoring of chronic demyelination and remyelination in a rat ischemic stroke model using macromolecular proton fraction mapping
    Marina Yu Khodanovich, Ilya L Gubskiy, Marina S Kudabaeva, Darya D Namestnikova, Alena A Kisel, Tatyana V Anan’ina, Yana A Tumentceva, Lilia R Mustafina, Vasily L Yarnykh
    Journal of Cerebral Blood Flow & Metabolism 2021 41 11

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