More articles from ADULT BRAIN
- Monoclonal Antibodies: What the Diagnostic Neuroradiologist Needs to Know
The therapeutic use of monoclonal antibodies is rapidly expanding for a variety of diseases. This review article describes commonly used monoclonal antibody-targeted therapeutic agents, their mechanism of action, clinical applications, and major adverse events with a focus on neurologic and neuroimaging manifestations. For example, immunostimulating anticancer mAbs can lead to proinflammatory conditions, while immunosuppressive medications can lead to activation of underlying opportunistic infections. Amyloid-segregating mAbs can lead to amyloid-related imaging abnormalities, and TNF-inhibiting mAbs have a higher incidence of demyelinating abnormalities.
- Prospective, Longitudinal Study of Clinical Outcome and Morphometric Posterior Fossa Changes after Craniocervical Decompression for Symptomatic Chiari I Malformation
This prospective, longitudinal study of patients with Chiari I malformation posterior fossa dural opening and duraplasty quantified the change in the posterior fossa and upper cervical spine morphometrics and determined the change in symptomatology between at baseline and up to 5 years postsurgery. The authors found that symptomatic and MR imaging morphometric changes occurred within the first postoperative year.
- Longitudinal Changes in Cerebral Perfusion, Perivascular Space Volume, and Ventricular Volume in a Healthy Cohort Undergoing a Spaceflight Analog
Cerebral physiologic changes occur in response to the unique physiologic stressor of altered gravity, including a decrease in global perfusion and increase in ventricular/PVS volumes during spaceflight analog and subsequent reversal during recovery. The findings of this study contribute to our understanding of the relationships among the circulatory, glymphatic, and ventricular systems of the brain.
- Unpacking the CNS Manifestations of Epstein-Barr Virus: An Imaging Perspective
This is an illustrative review of neuroimaging manifestations of EBV-associated infectious, noninfectious inflammatory, and lymphoproliferative disorders, which have a myriad of imaging appearances.
- Long-Term Follow-up of Multinodular and Vacuolating Neuronal Tumors and Implications for Surveillance Imaging
Multinodular and vacuolating neuronal tumors (MVNTs) are classified as WHO grade 1 tumors and typically described as “leave me alone” lesions. Less frequent surveillance imaging can be performed based on the longitudinal volumetric stability of these lesions.