Article Figures & Data
Figures
- Fig 1.
Arterial arrival times measured from angiographic time-density curves. ROIs within the normal MCA proximal M1 segment (white arrow, A) and from collateralized MCA branches (double arrows, A) are identified on composite angiographic images. ROIs were used to calculate time-density curves (B). “Average arterial time” (in seconds) was defined as the time interval between contrast arrival at the normal M1 segment (interrupted curve, B) and the average of 3 ROIs at the M3/4 junction of the MCA corresponding to the occluded MCA (continuous curve, B). AAT is graphically depicted by the horizontal double arrow line.
- Fig 2.
Final infarct volumes by T2 FLAIR images acquired 24 hours post-MCA occlusion are compared with baseline (ie, 15 minutes postocclusion) angiographic measures of pial collateral recruitment. A, Angiographic scoring of pial collateral score and arterial arrival time (B) strongly correlates with final infarct volume. Both pial collateral score (C) and AAT (D) are predictive the infarct growth rate index (derived from the fits shown in Fig 3B) on the basis of a linear function.
- Fig 3.
Single-section 120-minute mean diffusivity (upper part) and 24-hour FLAIR (lower part) images (A) were used to estimate and plot the growth of the infarct volume with time (B). A semiautomated algorithm was used to estimate the volume of the infarct on the basis of signal intensity within the affected hemisphere (red area), varying 1.5 times the SD from the mean of the signal in the contralateral normal-appearing hemisphere exclusive of spinal fluid. B, Infarct volume growth with time follows a predicable trend. Each curve corresponds to 1 experiment. The pial collateral scores and AAT measured immediately after occlusion (ie, at t = 15 minutes) for each curve are listed on the right.
- Fig 4.
Families of infarct volume growth curves over 24 hours predicted by the pial collateral score and arterial arrival time.
Tables
Experiment No. 1 2 3 4 5 6 Pc 9.00 7.00 10.50 5.50 4.00 3.50 AAT (sec) 1.344 3.469 1.812 4.938 4.656 4.156 V (60 min) (mm3) 3533 8960 3575 9842 14,947 15,074 V (90 min) (mm3) 3976 9221 4009 10,310 15,428 16,464 V (120 min) (mm3) 3922 9174 4430 14,493 16,805 18,134 V (180 min) (mm3) 5492 13,043 5312 16,811 18,034 20,694 V (240 min) (mm3) 5058 14,800 6461 17,419 19,257 22,197 V (24 hr) (mm3) 9612 17,987 9668 20,946 24,479 25,419 Note:—V (time) indicates infarct volume at “time” evaluated with diffusion-weighted MRI; V (24 hour), final infarct volume from FLAIR MRI.
Experiment G (95% CI) ×(10−3)1/min Vfit (95% CI) ×1000 mm3 r2 1 4.765 (2.37–7.16) 9.31 (7.08–11.55) 0.92 2 7.951 (4.65–11.25) 17.58 (14.52–20.63) 0.96 3 5.337 (3.629–7.05) 9.467 (8.04–10.89) 0.97 4 9.23 (6.79–11.67) 20.54 (18.41–22.67) 0.98 5 14.20 (5.64–22.75) 21.65 (17.64–25.66) 0.94 6 13.22 (8.79–17.67) 23.95 (21.36–26.54) 0.98 Note:—G indicates growth rate index from fit; Vfit, final infarct volume from fit; r2 = coefficient of determination of fit.
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