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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleADULT BRAIN

T1 Recovery Is Predominantly Found in Black Holes and Is Associated with Clinical Improvement in Patients with Multiple Sclerosis

C. Thaler, T.D. Faizy, J. Sedlacik, B. Holst, K. Stürner, C. Heesen, J.-P. Stellmann, J. Fiehler and S. Siemonsen
American Journal of Neuroradiology February 2017, 38 (2) 264-269; DOI: https://doi.org/10.3174/ajnr.A5004
C. Thaler
aFrom the Departments of Diagnostic and Interventional Neuroradiology (C.T., T.D.F., J.S., B.H., J.F., S.S.)
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T.D. Faizy
aFrom the Departments of Diagnostic and Interventional Neuroradiology (C.T., T.D.F., J.S., B.H., J.F., S.S.)
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J. Sedlacik
aFrom the Departments of Diagnostic and Interventional Neuroradiology (C.T., T.D.F., J.S., B.H., J.F., S.S.)
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B. Holst
aFrom the Departments of Diagnostic and Interventional Neuroradiology (C.T., T.D.F., J.S., B.H., J.F., S.S.)
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K. Stürner
bNeurology (K.S., C.H., J.-P.S.)
cInstitute for Neuroimmunology and Clinical MS Research (K.S., C.H., J.-P.S., S.S.), University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
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C. Heesen
bNeurology (K.S., C.H., J.-P.S.)
cInstitute for Neuroimmunology and Clinical MS Research (K.S., C.H., J.-P.S., S.S.), University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
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J.-P. Stellmann
bNeurology (K.S., C.H., J.-P.S.)
cInstitute for Neuroimmunology and Clinical MS Research (K.S., C.H., J.-P.S., S.S.), University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
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J. Fiehler
aFrom the Departments of Diagnostic and Interventional Neuroradiology (C.T., T.D.F., J.S., B.H., J.F., S.S.)
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S. Siemonsen
aFrom the Departments of Diagnostic and Interventional Neuroradiology (C.T., T.D.F., J.S., B.H., J.F., S.S.)
cInstitute for Neuroimmunology and Clinical MS Research (K.S., C.H., J.-P.S., S.S.), University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
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    Fig 1.

    An example of ROI placement in T1WI MPRAGE at baseline. From left to right: 1) T1WI MPRAGE transversal without lesion ROIs, 2) ROIs indicating FLAIR-lesion masks, 3) ROIs indicating black hole lesion masks, and 4) ROIs indicating FLAIR-lesion masks without black holes (pure FLAIR lesion masks).

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    Fig 2.

    Boxplots showing T1 relaxation times at baseline and after 12-month follow-up for different lesion types. P values were calculated by using a paired t test.

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    Fig 3.

    Scatterplots showing an association between lesional changes in T1 relaxation times and clinical scores.

Tables

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  • Subject population

    MeanSDRange
    Age (yr)35.19.518–51
    EDSS baseline2.21.60–6.5
    Disease duration (yr)7.76.10.1–19
    Sex11 women, 6 men
    Disease course17 RRMS
    • Note:—RRMS indicates relapsing-remitting MS.

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American Journal of Neuroradiology: 38 (2)
American Journal of Neuroradiology
Vol. 38, Issue 2
1 Feb 2017
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Cite this article
C. Thaler, T.D. Faizy, J. Sedlacik, B. Holst, K. Stürner, C. Heesen, J.-P. Stellmann, J. Fiehler, S. Siemonsen
T1 Recovery Is Predominantly Found in Black Holes and Is Associated with Clinical Improvement in Patients with Multiple Sclerosis
American Journal of Neuroradiology Feb 2017, 38 (2) 264-269; DOI: 10.3174/ajnr.A5004

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T1 Recovery Is Predominantly Found in Black Holes and Is Associated with Clinical Improvement in Patients with Multiple Sclerosis
C. Thaler, T.D. Faizy, J. Sedlacik, B. Holst, K. Stürner, C. Heesen, J.-P. Stellmann, J. Fiehler, S. Siemonsen
American Journal of Neuroradiology Feb 2017, 38 (2) 264-269; DOI: 10.3174/ajnr.A5004
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