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Research ArticleADULT BRAIN
Open Access

Mitotic Activity in Glioblastoma Correlates with Estimated Extravascular Extracellular Space Derived from Dynamic Contrast-Enhanced MR Imaging

S.J. Mills, D. du Plessis, P. Pal, G. Thompson, G. Buonacorrsi, C. Soh, G.J.M. Parker and A. Jackson
American Journal of Neuroradiology May 2016, 37 (5) 811-817; DOI: https://doi.org/10.3174/ajnr.A4623

Article Figures & Data

Figures

  • Fig 1.
    Fig 1.

    A, Boxplot of fibrillar histology and ve (estimated P = .007). Sample histologic specimens showing tumors without (B) and with (C) the presence of fibrils (small fibers measuring approximately 1 mm, black arrows, C). H&E stain ×40 magnification. D, Boxplot of frank necrosis and Ktrans (estimated P = .005).

  • Fig 2.
    Fig 2.

    Scatterplot of mitotic activity versus ve (P = .012, ρ = 0.470), marker shapes depict separate scores of cell density measures.

Tables

  • Table 1:

    Cross-correlations of MRI parametersa

    Untreated GBM (n = 28)
    vevpEnFIAUC60>0EnFIAUC60>2.5
    Ktrans0.016,b ρ = 0.4500.006,c ρ = 0.5070.005,c ρ = 0.513<0.001,c ρ = 0.784
    ve0.105, ρ = 0.3130.888, ρ = 0.0280.059, ρ = 0.361
    vp0.02,b ρ = 0.437<0.001,c ρ = 0.620
    EnFIAUC60>0<0.001,c ρ = 0.825

    • ↵a Significance levels and Spearman ρ are shown.

    • ↵b Significance was P < .05.

    • ↵c Significance was P < .01.

  • Table 2:

    Cross-correlations of quantitative histologic measuresa

    Untreated GBM (n = 28)
    ESA RatioVSA RatioVPC/mm2
    Mitotic activity0.098, ρ = 0.3250.066, ρ = 0.3580.737, ρ = 0.068
    ESA ratio<0.001,b ρ = 0.9930.04,c ρ = 0.530
    VSA ratio0.04,c ρ = 0.532

    • Note:—VPC indicates vascular profile count per square millimeter; VSA, vascular surface area; ESA, endothelial surface area.

    • ↵a Significance levels and Spearman ρ are shown.

    • ↵b Significance was P < .01.

    • ↵c Significance was P < .05.

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Mitotic Activity in Glioblastoma Correlates with Estimated Extravascular Extracellular Space Derived from Dynamic Contrast-Enhanced MR Imaging
S.J. Mills, D. du Plessis, P. Pal, G. Thompson, G. Buonacorrsi, C. Soh, G.J.M. Parker, A. Jackson
American Journal of Neuroradiology May 2016, 37 (5) 811-817; DOI: 10.3174/ajnr.A4623
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