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Research ArticleAdult Brain
Open Access

Vascular Dysfunction in Leukoaraiosis

K. Sam, A.P. Crawley, J. Poublanc, J. Conklin, O. Sobczyk, D.M. Mandell, J. Duffin, L. Venkatraghavan, J.A. Fisher, S.E. Black and D.J. Mikulis
American Journal of Neuroradiology December 2016, 37 (12) 2258-2264; DOI: https://doi.org/10.3174/ajnr.A4888
K. Sam
aFrom the Departments of Physiology (K.S., J.D., J.A.F.)
cDivision of Neuroradiology (K.S., A.P.C., J.P., J.C., O.S., D.M.M., D.J.M.), Joint Department of Medical Imaging, University Health Network, Toronto, Ontario, Canada
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A.P. Crawley
bMedical Imaging (A.P.C., D.J.M.), University of Toronto, Toronto, Ontario, Canada
cDivision of Neuroradiology (K.S., A.P.C., J.P., J.C., O.S., D.M.M., D.J.M.), Joint Department of Medical Imaging, University Health Network, Toronto, Ontario, Canada
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J. Poublanc
cDivision of Neuroradiology (K.S., A.P.C., J.P., J.C., O.S., D.M.M., D.J.M.), Joint Department of Medical Imaging, University Health Network, Toronto, Ontario, Canada
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J. Conklin
cDivision of Neuroradiology (K.S., A.P.C., J.P., J.C., O.S., D.M.M., D.J.M.), Joint Department of Medical Imaging, University Health Network, Toronto, Ontario, Canada
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O. Sobczyk
cDivision of Neuroradiology (K.S., A.P.C., J.P., J.C., O.S., D.M.M., D.J.M.), Joint Department of Medical Imaging, University Health Network, Toronto, Ontario, Canada
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D.M. Mandell
cDivision of Neuroradiology (K.S., A.P.C., J.P., J.C., O.S., D.M.M., D.J.M.), Joint Department of Medical Imaging, University Health Network, Toronto, Ontario, Canada
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J. Duffin
aFrom the Departments of Physiology (K.S., J.D., J.A.F.)
dDepartment of Anesthesiology (J.D., L.V., J.A.F.), University Health Network and The University of Toronto, Toronto, Ontario, Canada
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L. Venkatraghavan
dDepartment of Anesthesiology (J.D., L.V., J.A.F.), University Health Network and The University of Toronto, Toronto, Ontario, Canada
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J.A. Fisher
aFrom the Departments of Physiology (K.S., J.D., J.A.F.)
dDepartment of Anesthesiology (J.D., L.V., J.A.F.), University Health Network and The University of Toronto, Toronto, Ontario, Canada
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S.E. Black
eL.C. Campbell Cognitive Neurology Research Unit (S.E.B.), Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
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D.J. Mikulis
bMedical Imaging (A.P.C., D.J.M.), University of Toronto, Toronto, Ontario, Canada
cDivision of Neuroradiology (K.S., A.P.C., J.P., J.C., O.S., D.M.M., D.J.M.), Joint Department of Medical Imaging, University Health Network, Toronto, Ontario, Canada
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Article Information

vol. 37 no. 12 2258-2264
DOI 
https://doi.org/10.3174/ajnr.A4888
PubMed 
27492072

Published By 
American Journal of Neuroradiology
Print ISSN 
0195-6108
Online ISSN 
1936-959X
History 
  • Received November 20, 2015
  • Accepted after revision June 7, 2016
  • Published online December 15, 2016.

Article Versions

  • Latest version (August 4, 2016 - 06:59).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2016 by American Journal of Neuroradiology Indicates open access to non-subscribers at www.ajnr.org

Author Information

  1. K. Sama,c,
  2. A.P. Crawleyb,c,
  3. J. Poublancc,
  4. J. Conklinc,
  5. O. Sobczykc,
  6. D.M. Mandellc,
  7. J. Duffina,d,
  8. L. Venkatraghavand,
  9. J.A. Fishera,d,
  10. S.E. Blacke and
  11. D.J. Mikulisb,c
  1. aFrom the Departments of Physiology (K.S., J.D., J.A.F.)
  2. bMedical Imaging (A.P.C., D.J.M.), University of Toronto, Toronto, Ontario, Canada
  3. cDivision of Neuroradiology (K.S., A.P.C., J.P., J.C., O.S., D.M.M., D.J.M.), Joint Department of Medical Imaging, University Health Network, Toronto, Ontario, Canada
  4. dDepartment of Anesthesiology (J.D., L.V., J.A.F.), University Health Network and The University of Toronto, Toronto, Ontario, Canada
  5. eL.C. Campbell Cognitive Neurology Research Unit (S.E.B.), Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
  1. Please address correspondence to David John Mikulis, MD, Toronto Western Hospital, Joint Department of Medical Imaging, McLaughlin Pavilion, 3rd Floor, Room 431, 399 Bathurst St, Toronto, ON M5T 2S8, Canada; e-mail: mikulis{at}uhnres.utoronto.ca
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Cite this article
K. Sam, A.P. Crawley, J. Poublanc, J. Conklin, O. Sobczyk, D.M. Mandell, J. Duffin, L. Venkatraghavan, J.A. Fisher, S.E. Black, D.J. Mikulis
Vascular Dysfunction in Leukoaraiosis
American Journal of Neuroradiology Dec 2016, 37 (12) 2258-2264; DOI: 10.3174/ajnr.A4888

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Vascular Dysfunction in Leukoaraiosis
K. Sam, A.P. Crawley, J. Poublanc, J. Conklin, O. Sobczyk, D.M. Mandell, J. Duffin, L. Venkatraghavan, J.A. Fisher, S.E. Black, D.J. Mikulis
American Journal of Neuroradiology Dec 2016, 37 (12) 2258-2264; DOI: 10.3174/ajnr.A4888
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  • The Relationship between Cerebrovascular Reactivity and Cerebral Oxygenation during Hemodialysis
  • Intracranial hemodynamic relationships in patients with cerebral small vessel disease
  • White Matter Lesion Penumbra Shows Abnormalities on Structural and Physiologic MRIs in the Coronary Artery Risk Development in Young Adults Cohort
  • Intracranial functional haemodynamic relationships in patients with cerebral small vessel disease
  • Leukoaraiosis severity and outcomes after mechanical thrombectomy with stent-retriever devices in acute ischemic stroke
  • Pathogenesis of white matter changes in cerebral small vessel diseases: beyond vessel-intrinsic mechanisms
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  • Google Scholar

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    Cardiovascular Research 2018 114 11
  • Advances in Understanding the Pathophysiology of Lacunar Stroke
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  • Intracranial hemodynamic relationships in patients with cerebral small vessel disease
    Gordon W. Blair, Michael J. Thrippleton, Yulu Shi, Iona Hamilton, Michael Stringer, Francesca Chappell, David Alexander Dickie, Peter Andrews, Ian Marshall, Fergus N. Doubal, Joanna M. Wardlaw
    Neurology 2020 94 21
  • Pathogenesis of white matter changes in cerebral small vessel diseases: beyond vessel-intrinsic mechanisms
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    Clinical Science 2017 131 8
  • Incidence and risk factors of leukoaraiosis from 4683 hospitalized patients
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    Medicine 2017 96 39
  • Pathophysiology of Lacunar Stroke: History's Mysteries and Modern Interpretations
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  • Leukoaraiosis severity and outcomes after mechanical thrombectomy with stent-retriever devices in acute ischemic stroke
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    Journal of NeuroInterventional Surgery 2019 11 2
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    Yiyi Chen, Xing Wang, Ling Guan, Yilong Wang
    Biomolecules 2021 11 8
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