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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleBRAIN

The Ependymal “Dot-Dash” Sign: An MR Imaging Finding of Early Multiple Sclerosis

Christopher J. Lisanti, Patrick Asbach and William G. Bradley
American Journal of Neuroradiology September 2005, 26 (8) 2033-2036;
Christopher J. Lisanti
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Patrick Asbach
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William G. Bradley Jr.
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    Fig 1.

    Sagittal fluid-attenuated inversion recovery image (TR/TE/TI, 8800/130/2200) shows a normal smooth ependymal stripe (arrows) without irregularity, subcallosal striations, or Dot-Dash sign.

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    Fig 2.

    Sagittal fluid-attenuated inversion recovery images (TR/TE/TI, 8800/130/2200) from 2 different patients with multiple sclerosis (A, B) show the typical Dot-Dash sign. The arrows indicate the dots, whereas the dashes are the hypointense areas between the dots.

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    Fig 3.

    Sagittal fluid-attenuated inversion recovery images (TR/TE/TI, 8800/133/2200) are from a patient with recurrent relapsing multiple sclerosis. A shows the typical Dot-Dash sign (arrows). The patient developed worsening neurologic symptoms, and a follow-up image obtained 7 weeks later (B) showed interval development of confluent callosal and white matter lesions (arrowheads) and an additional Dot-Dash sign in the posterior ependyma.

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    Fig 4.

    Sagittal fluid-attenuated inversion recovery image (TR/TE/TI, 8800/130/2200) shows confluent subependymal and callosal white matter hyperintensity (arrows), which is typical of chronic white matter ischemic changes. There is no evidence of either the Dot-Dash sign or subcallosal striations.

Tables

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  • Comparison of controls and patients (divided by age)

    Overall (n = 70)Group I (n = 55)Group II (n = 15)
    %
    Sensitivity91.495.783.3
    Specificity65.771.933.3
    Positive predictive value72.771.083.3
    Negative predictive value88.595.833.3
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American Journal of Neuroradiology: 26 (8)
American Journal of Neuroradiology
Vol. 26, Issue 8
1 Sep 2005
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Cite this article
Christopher J. Lisanti, Patrick Asbach, William G. Bradley
The Ependymal “Dot-Dash” Sign: An MR Imaging Finding of Early Multiple Sclerosis
American Journal of Neuroradiology Sep 2005, 26 (8) 2033-2036;

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The Ependymal “Dot-Dash” Sign: An MR Imaging Finding of Early Multiple Sclerosis
Christopher J. Lisanti, Patrick Asbach, William G. Bradley
American Journal of Neuroradiology Sep 2005, 26 (8) 2033-2036;
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