Article Figures & Data
Figures
- Fig 1.
A 74-year-old man with right hemiparesis and aphasia. Intravenous r-tPA was administered after nonenhanced CT was performed 2.5 hours after symptom onset.
A, DW image and ADC map obtained 3 hours after CT show ischemic edema in the left MCA territory. TTP, rCBV, and rCBF maps show perfusion abnormality.
B, Gd-enhanced T1-weighted image (T1WI) shows a focal enhancing area in the left basal ganglia (arrow). Follow-up nonenhanced CT scan (NCT) depicts a small parenchymal hematoma in the left basal ganglia that corresponds to the enhancing area.
- Fig 2.
A 57-year-old woman with right hemiparesis and aphasia. Intravenous r-tPA was administered after nonenhanced CT was performed 1.5 hours after symptom onset.
A, DW image and ADC map obtained 3.7 hours after CT show ischemic edema and perfusion abnormality in the left MCA territory. TTP and rCBF maps show reperfusion in the area of parenchymal enhancement.
B, Gd-enhanced T1-weighted image (Gd-T1WI) shows parenchymal enhancement in the left perisylvian cortex and basal ganglia (arrowheads). Enhancing lesion in the right temporal lobe (white arrow) indicates subacute infarction. Patient had atrial fibrillation and infarction 2 months earlier. Follow-up EPI-GRE image shows focal hemorrhage (hemorrhagic infarct type 1) in only the left basal ganglia (black arrow). No hemorrhage is present in the rest of area of parenchymal enhancement in the left MCA territory and in right temporal lobe on the enhanced T1-weighted image.
Tables
Variable No HT (n = 36) HT (n = 19) P Value DWI lesion volume (cm3) 24.2 ± 34.7 50.9 ± 84.4 .115 Mean ADC (× 10−6 mm2/second) 59 ± 78 550 ± 101 .107 Voxels with ADC ≤550 × 10−6 mm2/second Percentage 42.5 ± 21.6 49.2 ± 22.1 .287 Absolute number 721.1 ± 1077.6 2887.3 ± 8109.1 .134 Voxels with ADC ≤450 × 10−6 mm2/second Percentage 20.9 ± 16.9 27.1 ± 21.0 .248 Absolute number 355.6 ± 516.4 14055.9 ± 58466.7 .181 Voxels with ADC ≤350 × 10−6 mm2/second Percentage 7.0 ± 8.5 11.7 ± 19.4 .239 Absolute number 128.3 ± 230.3 910.7 ± 2876.8 .124 Voxels with ADC ≤250 × 10−6 mm2/second Percentage 1.6 ± 2.5 5.4 ± 16.8 .216 Absolute number 32.8 ± 77.8 233.9 ± 672.4 .093 Gd enhancement 0 (0) 5 (26.3) .003 Note.—Data are the mean ± standard deviation or number (percentage).
Variable Enhancing Lesions Nonenhancing Lesions P Value DWI signal intensity ratio 1.49 ± 0.33 1.98 ± 0.55 .109 Mean ADC (× 10−6 mm2/second) 592 ± 62 510 ± 35 .068 ADC ratio 0.76 ± 0.06 0.66 ± 0.06 .066 TTP delay (second) 0.10 ± 2.79 8.79 ± 4.86 .068 Relative CBV 1.42 ± 0.26 0.86 ± 0.30 .144 Relative CBF 1.58 ± 0.99 0.59 ± 0.33 .068 Note.—Data are the mean ± standard deviation.
In this issue
Jump to section
Related Articles
Cited By...
- Use of MRI to predict symptomatic haemorrhagic transformation after thrombolysis for cerebral ischaemia
- Treatment and Outcome of Hemorrhagic Transformation After Intravenous Alteplase in Acute Ischemic Stroke: A Scientific Statement for Healthcare Professionals From the American Heart Association/American Stroke Association
- Decreased Infarct Volume and Intracranial Hemorrhage Associated with Intra-Arterial Nonionic Iso-Osmolar Contrast Material in an MCA Occlusion/Reperfusion Model
- Pretreatment Blood-Brain Barrier Damage and Post-Treatment Intracranial Hemorrhage in Patients Receiving Intravenous Tissue-Type Plasminogen Activator
- Effects of Microvascular Permeability Changes on Contrast-Enhanced T1 and Pharmacokinetic MR Imagings After Ischemia
- Hemorrhagic Risk of Recent Silent Cerebral Infarct on Prethrombolysis MR Imaging in Acute Stroke
- Patterns and Predictors of Blood-Brain Barrier Permeability Derangements in Acute Ischemic Stroke
- The HAT Score: A simple grading scale for predicting hemorrhage after thrombolysis
- Early Disruption of the Blood-Brain Barrier After Thrombolytic Therapy Predicts Hemorrhage in Patients With Acute Stroke
- Haemorrhagic transformation in acute ischaemic stroke following thrombolysis therapy: classification, pathogenesis and risk factors
- MRI Detection of Early Blood-Brain Barrier Disruption: Parenchymal Enhancement Predicts Focal Hemorrhagic Transformation After Thrombolysis
- Elevated Serum S100B Levels Indicate a Higher Risk of Hemorrhagic Transformation After Thrombolytic Therapy in Acute Stroke
- Intracranial Hemorrhage Associated With Revascularization Therapies