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693 APX601, a Novel TNFR2 antagonist antibody for cancer immunotherapy
Erin Filbert, Sushma Krishnan, Ryan Alvarado, George Huang, Francis Bahjat, Xiaodong Yang

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A417; DOI: 10.1136/jitc-2020-SITC2020.0693
695 Oral delivery of a microbial extracellular vesicle induces potent anti-tumor immunity in mice
Loise Francisco-Anderson, Loise Francisco-Anderson, Mary Abdou, Michael Goldberg, Erin Troy, Alicia Ballok, Fabian Romano Chernac, Maria Sizova, Krutika Invally, Shubhra Kashyap, Audrey McBride, Jessica Tsang, Shannon Argueta, Kristie Barth, Valeria Kravitz, Holly Ponichtera, Tyler Rommel, Kevin Huynh, Tanmoy Ganguly, Mark Bodmer, Mark Bodmer

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A418; DOI: 10.1136/jitc-2020-SITC2020.0695
697 Tumor-targeted CD28 costimulatory bispecific antibodies enhance T cell activation in solid tumors
Michael Hedvat, Veronica Zeng, Juan Diaz, Christine Bonzon, Kendra Avery, Rumana Rashid, Irene Leung, Norm Bartlow, Charles Bakhit, Matthew Dragovich, Liz Bogart, Umesh Muchhal, John Desjarlais, Gregory Moore

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A419; DOI: 10.1136/jitc-2020-SITC2020.0697
704 Preclinical mechanism of action and pharmacodynamic biomarker studies of DuoBody®-CD3x5T4 in vitro and in vivo in solid cancer models
Kristel Kemper, Ellis Gielen, Mischa Houtkamp, Peter Boross, Saskia Burm, Stefanie De Poot, Patrick Engelberts, Bart de Goeij, David Satijn, Kate Sasser, Esther Breij

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A423; DOI: 10.1136/jitc-2020-SITC2020.0704
707 Discovery of a novel EP2 and EP4 dual antagonist
Yeri Lee, Hyun Jin Kim, Donggeon Kim, Joo Youn Lee, Chang Soo Yun, Hyuk Lee, Young Sook Shin, Soo Bong Han, Sang Kyun Lim

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A424-A425; DOI: 10.1136/jitc-2020-SITC2020.0707
70 Beyond PD-L1: novel PD-1 biomarkers identified by driving T cell dysfunction in vitro
Simarjot Pabla, Tenzing Khendu, Dhan Chand, Bulent Aksoy, Benjamin Duckless, Andrew Basinski, Cailin Joyce, Thomas Horn, Lukasz Swiech, Jeremy Waight, David Savitsky, Jennifer Buell

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A43; DOI: 10.1136/jitc-2020-SITC2020.0070
718 AMG 509, a STEAP1 x CD3 bispecific XmAb^® 2+1 immune therapy, exhibits avidity-driven binding and preferential killing of high STEAP1-expressing prostate and Ewing sarcoma cancer cells
Cong Li, Madeline Fort, Lingming Liang, Gregory Moore, Matthew Bernett, Umesh Muchhal, Tao Osgood, Rodolfo Yabut, Sarav Kaliyaperumal, John Harrold, Jude Canon, Anna Rogojina, Raushan Kurmasheva, John Desjarlais, Peter Houghton, Olivier Nolan-Stevaux

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A430; DOI: 10.1136/jitc-2020-SITC2020.0718
72 Routine use of comprehensive genomic profiling to assess tumor mutational burden across a community health system
Carlo Bifulco, Roshanthi Weerasinghe, Bela Bapat, Alexa Dowdell, Shwetha Pindikuri, Sheila Reynolds, Nancy Biery, David Ball, Mary Campbell, Thomas Ward, Alisha Stein, Brock Schroeder, David Eberhard, Brian Piening

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A44-A45; DOI: 10.1136/jitc-2020-SITC2020.0072
71 Whole exome sequencing of individuals presenting extreme phenotypes of high and low-risk of developing tobacco-induced lung adenocarcinoma: relevance of immune and DNA-repair related pathways
Jose Perez-Gracia, Mapi Andueza, Ana Patiño-Garcia, Alfonso Gurpide

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A44; DOI: 10.1136/jitc-2020-SITC2020.0071
74 Novel approach for profiling immune-tumor cell interactions and mutations in the same tumor section by multiplex immunohistochemistry and NGS in immuno-oncology trials
Nathan Riccitelli, Jennifer Bordeaux, Nancy Valencia, Ju Young Kim, Sarah Johnson, Nathan Roscoe, James Santos, Justin Santos, Jacob Levy, Deepika Asnani, Tracie Cobb, Angela McIntosh, Xun Li, Shabnam Tangri, Reinhold Pollner, Naveen Dakappagari

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A45; DOI: 10.1136/jitc-2020-SITC2020.0074

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