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773 Adoptive Cell Therapy Response in Melanoma is Mediated by Stem-like CD8 T cells
Sri Krishna, Frank Lowery, Amy Copeland, Stephanie Goff, Grégoire Altan-Bonnet, Paul Robbins, Steven Rosenberg

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A463-A464; DOI: 10.1136/jitc-2020-SITC2020.0773
772 A potent and off-the-shelf oNK cell therapy product targets HER2+ cancer cells and resists suppressive tumor microenvironment
Hao-Kang Li, Ching-Wen Hsiao, Sen-Han Yang, Hsiu-Ping Yang, Tai-Sheng Wu, Zih-Fei Cheng, Chia-Yun Lee, Yan-Liang Lin, Yan-Da Lai, Sai-Wen Tang, Janet Pan, Wei-Lun Lo, Shih-Chia Hsiao

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A463; DOI: 10.1136/jitc-2020-SITC2020.0772
774 Antibiotic administration prior to immunotherapy leads to poor overall survival across multiple malignancies
Eric Vick, Inas Abuali, Sarah Ludvigsen, Andrew Kelleher, Nathanael Moore, Nicholas Arias, Shuchi Gulati, Trisha Wise-Draper

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A464-A465; DOI: 10.1136/jitc-2020-SITC2020.0774
775 Rare case reports on thymic carcinoma patients treated with pembrolizumab
Evelyn Paszkan, Erna Ganofszky, Zsolt Megyesfalvi, Aron Ghimessy, Balazs Dome, Laszlo Agocs, Erika Toth, Ferenc Renyi-Vamos, Gabor Rubovszky

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A465; DOI: 10.1136/jitc-2020-SITC2020.0775
779 Immune checkpoint blockade impacts the suppressive phenotype and function of regulatory T cells in an endogenous mouse lymphoma model
Vera Bauer, Fatima Ahmetlic, Martin Roecken, Ralph Mocikat, Ralph Mocikat

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A467-A468; DOI: 10.1136/jitc-2020-SITC2020.0779
778 Preclinical study using a glutamatergic signaling and immune-checkpoint inhibitors in a spontaneous melanoma prone mouse model
Kevinn Eddy, Christina Marinaro, Maryam Rasheed, Joseph Campagnolo, Xiaoxuan Zhong, Mohamad Eddin, Raj Shah, Kajal Gupta, Jesus Diaz, Andrew Zloza, Suzie Chen

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A467; DOI: 10.1136/jitc-2020-SITC2020.0778
76 Potential mechanisms of resistance identified through analysis of multiple biomarkers in immune hot non-responders with non-small cell lung cancer (NSCLC) treated with tislelizumab
Jayesh Desai, Qing Zhou, Sanjeev Deva, Jun Zhao, Jie Wang, Wei Tan, Xiaopeng Ma, Yun Zhang, Zhirong Shen, Xikun Wu, Shiangjiin Leaw, Juan Zhang, Yi-Long Wu

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A47; DOI: 10.1136/jitc-2020-SITC2020.0076
795 A multicenter phase II trial (SWOG S1609, cohort 51) of ipilimumab and nivolumab in metastatic or unresectable angiosarcoma: a substudy of dual anti-CTLA-4 and anti-PD-1 blockade in rare tumors (DART)
Michael Wagner, Megan Othus, Sandip Patel, Christopher Ryan, Ashish Sangal, Benjamin Powers, George Budd, Adrienne Victor, Chung-Tsen Hsueh, Rashmi Chugh, Suresh Nair, Kirsten Leu, Mark Agulnik, Elad Sharon, Edward Mayerson, Melissa Plets, Charles Blanke, Howard Streicher, Young Kwang Chae, Razelle Kurzrock

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A475; DOI: 10.1136/jitc-2020-SITC2020.0795
797 Significant anti-tumor activity of HBI-8000, a class I histone deacetylase inhibitor (HDACi) in combination with nivolumab (NIVO) in anti-PD1 therapy-naïve advanced melanoma (TN-Mel)
Nikhil Khushalani, Andrew Brohl, Joseph Markowitz, Lyudmila Bazhenova, Gregory Daniels, Heather Yeckes-Rodin, Siqing Fu, Lori McCormick, Michael Kurman, Mireille Gillings, Gloria Lee, Zeynep Eroglu

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A476-A477; DOI: 10.1136/jitc-2020-SITC2020.0797
802 Ramucirumab plus atezolizumab in patients with stage IV non-small cell lung cancer previously treated with immune checkpoint blockade
Brett Herzog, Saiama Waqar, Siddhartha Devarakonda, Jeffrey Ward, Ramaswamy Govindan, Daniel Morgensztern

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A480; DOI: 10.1136/jitc-2020-SITC2020.0802

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