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563 Pharmacodynamics and pharmacokinetics of SO-C101 in cynomolgus monkeys
Nada Podzimkova, Irena Adkins, Guy de Martynoff, David Bechard, Radek Spisek, Ulrich Moebius

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A339; DOI: 10.1136/jitc-2020-SITC2020.0563
564 Potency-reduced and extended half-life IL12 heterodimeric Fc-fusions exhibit strong anti-tumor activity with potentially improved therapeutic index compared to native IL12 agents
Matthew Bernett, Rajat Varma, Ke Liu, Christine Bonzon, Rumana Rashid, Nicole Rodriguez, Nargess Hassanzadeh-Kiabi, Connie Ardila, Seung Chu, Umesh Muchhal, John Desjarlais

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A340; DOI: 10.1136/jitc-2020-SITC2020.0564
567 MDK1319/MDK-701: A potent fully efficacious peptidyl agonist of IL-7Rαγc, designed with no reference to cytokine or receptor structure and unrelated to IL-7, fused to an Fc-domain for PK enhancement
William Dower, Alice Bakker, Steven Cwirla, Prarthana Joshi, Praechompoo Pongtornpipat, Blake Williams, Sandra Wang, Michael Needels, Ronald Barrett

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A341-A342; DOI: 10.1136/jitc-2020-SITC2020.0567
572 Fibroblast activating protein (FAP)-targeting IL-12 (anti-FAP/IL-12) TMEkine™ potentiates anti-cancer effects in preclinical cancer models
Donggeon Kim, Dahea Lee, Soomin Ryu, Yeongseon Byeon, Kyoung-Ho Pyo, Jae-Hwan Kim, Seul Lee, Dong Kwon Kim, Eun Ji Lee, Seung Yeon Oh, Byoung Chul Cho, Byoung Chul Lee

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A344; DOI: 10.1136/jitc-2020-SITC2020.0572
575 Regression by hetIL-15 monotherapy in different mouse breast cancer models correlates with intratumoral infiltration of a novel population of dendritic cells
Sevasti Karaliota, Dimitris Stellas, Vasiliki Stravokefalou, Bethany Nagy, Cristina Bergamaschi, Barbara Felber, George Pavlakis

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A345-A346; DOI: 10.1136/jitc-2020-SITC2020.0575
577 Engineered non-pathogenic synthetic biotic producing L-arginine synergize with PD-1-based cancer immunotherapy
Fernando Canale, Camilla Basso, Ning Li, Anna Sokolovska, Michela Perotti, Michael James, Wenjie Jin, Jean-Philippe Theurillat, Daniel Leventhal, Kip West, Jose Lora, Federica Sallusto, Roger Geiger

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A346; DOI: 10.1136/jitc-2020-SITC2020.0577
579 Lactate dehydrogenase C-associated molecular networks predict enhanced tumor growth and impaired immune response in breast cancer
Julie Decock, Adviti Jana

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A347; DOI: 10.1136/jitc-2020-SITC2020.0579
595 Armed myxoma virus demonstrates efficacy in syngeneic tumor models alone and in combination with immune checkpoint inhibitors
Lina Franco, Lino Torres-Dominguez, Joseph Mamola, Ana de Matos, Mario Abrantes, Benjamin Walker, Zachary Tacner, Cassandra Kien, Natalie Elliott, Grant McFadden, Leslie Sharp

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A356; DOI: 10.1136/jitc-2020-SITC2020.0595
35 Targeted non-viral integration of large cargo in primary human T cells by CRISPR/Cas9 guided homology mediated end joining
Beau Webber, Matthew Johnson, Nicholas Slipek, Walker Lahr, Xiaohong Qiu, Blaine Rathmann, Miechaleen Diers, Bryce Wick, R Scott McIvor, Branden Moriarity

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A36; DOI: 10.1136/jitc-2020-SITC2020.0035
606 Epidermal growth factor modulation of CXCL10 in keratinocytes and cutaneous cancers
Myles McCrary, David Gibbs, Carlos Moreno, Brian Pollack

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A362-A363; DOI: 10.1136/jitc-2020-SITC2020.0606

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