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608 Immunodominant listeria epitopes compete with vaccine-directed cd8+ t-cell responses rescued by peptide-MHC stabilizing modifications
John Flickinger, Jagmohan Singh, Yanki Yarman, Robert Carlson, Scott Waldman, Adam Snook

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A363-A364; DOI: 10.1136/jitc-2020-SITC2020.0608
611 RNA-sequencing reveals a unique immune transcriptional landscape in the vaccine sites of patients with circulating T-cell responses to cancer immunization
Max Meneveau, Pankaj Kumar, Kevin Lynch, Karlyn Pollack, Craig Slingluff

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A366-A368; DOI: 10.1136/jitc-2020-SITC2020.0611
613 HER2-XPAT, a novel protease-activatable prodrug T cell engager (TCE), with potent T-cell activation and efficacy in solid tumors and large predicted safety margins in non-human primate (NHP)
Fiore Cattaruzza, Ayesha Nazeer, Zachary Lange, Caitlin Koski, Mikhail Hammond, Trang Dao-Pick, Angela Henkensiefken, Mika Derynck, Volker Schellenberger, Bryan Irving

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A368-A369; DOI: 10.1136/jitc-2020-SITC2020.0613
612 Human CLEC9A antibodies deliver NY-ESO-1 antigen to CD141+ dendritic cells to activate naïve and memory NY-ESO-1-specific CD8+ T cells
Kelly-Anne Masterman, Oscar Haigh, Kirsteen Tullett, Ingrid Leal-Rojas, Carina Walpole, Frances Pearson, Jonathon Cebon, Christopher Schmidt, Liam O’Brien, Nikita Rosendahl, Ghazal Daraj, Irina Caminschi, Eric Gschweng, Roger Hollis, Donald Kohn, Mireille Lahoud, Kristen Radford, Kristen Radford

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A368; DOI: 10.1136/jitc-2020-SITC2020.0612
614 Co-stimulation via PD1–41BB chimeric switch receptor enhances function of TCR-T cells in an immune-suppressive milieu and under chronic antigen stimulation
Melanie Salvermoser, Maria Gerget, Franziska Hasselmann, Elfriede Noessner, Christian Ellinger, Monika Braun, Dolores Schendel, Daniel Sommermeyer, Nadja Sailer

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A369; DOI: 10.1136/jitc-2020-SITC2020.0614
59 Integrating deep proteomics profiling with survival analysis to identify novel biomarkers of response to PD-1 blockade in NSCLC patients
Kamil Sklodowski, Vito Dozio, Silvia Lopez-Lastra, Andrés Lanzós, Kristina Beeler, Emanuela Romano

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A37-A38; DOI: 10.1136/jitc-2020-SITC2020.0059
616 A novel non-covalent linker peptide with nanomolar affinity for clinical IgG1 antibodies preserves antibody-antigen affinity and drug potency against PDL1+ melanoma when conjugated with DM1
John Butterfield, Shari Sutor, Wendy Nevala, Svetomir Markovic

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A370-A371; DOI: 10.1136/jitc-2020-SITC2020.0616
618 Vedotin ADCs induce ER stress and elicit hallmarks of ICD across multiple cancer indications
Kerry Klussman, Elena-Marie Tenn, Shaylin Higgins, Rebecca Mazahreh, Katie Snead, Joseph Hamilton, Bryan Grogan, Johann Sigurjonsson, Anthony Cao, Shyra Gardai, Bernard Liu

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A372; DOI: 10.1136/jitc-2020-SITC2020.0618
619 Evaluating the effectiveness of targeted ADC therapy in a patient-derived ex vivo tumoroid model, 3D-EX, for quantitative tumor cell killing
Jenny Kreahling, Jared Ehrhart, Mibel Pabon, Stephen Iwanowycz, Tina Pastoor, Soner Altiok

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A372; DOI: 10.1136/jitc-2020-SITC2020.0619
620 Tumor cell-intrinsic STING pathway is activated in the presence of cues from immune cells and contributes to the anti-tumor activity of tumor cell-targeted STING agonist antibody-drug conjugates
Naniye Malli Cetinbas, Travis Monnell, Winnie Lee, Kalli Catcott, Chen-Ni Chin, Pamela Shaw, Kelly Slocum, LiuLiang Qin, Kenneth Avocetien, Keith Bentley, Susan Clardy, Brian Jones, Eugene Kelleher, Joshua Thomas, Rebecca Mosher, Dorin Toader, Jeremy Duvall, Raghida Bukhalid, Marc Damelin, Timothy Lowinger

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A373; DOI: 10.1136/jitc-2020-SITC2020.0620

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