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89 First-in-human CAR T targets cleaved MUC1, the growth factor receptor form
Benoit Smagghe, Andrew Stewart, Pengyu Huang, Tyler Swanson, Danica Page, Mark Carter, Trevor Grant, Jennifer Specht, Cynthia Bamdad

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A56-A57; DOI: 10.1136/jitc-2020-SITC2020.0089
88 Development of a 3D organoid autologous TIL co-culture platform for high throughput immuno-oncology studies
Garima Kaushik, Bhavna Verma, Amy Wesa

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A56; DOI: 10.1136/jitc-2020-SITC2020.0088
528 Sexual dimorphism in myeloid-derived suppressor cells promote GBM progression in females via IL-1b
Defne Bayik, Yadi Zhou, Chihyun Park, Chngjin Hong, Danielle Silver, Dionysios Watson, Alice Lo, Tae Hyun Hwang, Feixiong Cheng, Peter Sims, Antonio Iavarone, Justin Lathia

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A564; DOI: 10.1136/jitc-2020-SITC2020.0528
92 Adoptive transfer of immature myeloid cells lacking NF-κB p50 (p50-IMC) slows high-risk neuroblastoma tumor growth
Cheng Cui, Theresa Barberi, Rahul Suresh, Ludovic Zimmerlin, Elias Zambidis, Alan Friedman

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A58-A59; DOI: 10.1136/jitc-2020-SITC2020.0092
95 Inhibition of AKT signaling during expansion of TCR-engineered T-cells from patient leukocyte material generates SPEAR T-cells with enhanced functional potential in vitro
Katerina Mardilovich, Lilli Wang, Rachel Kenneil, Gareth Betts, Natalie Bath, Will Spinner, Vanessa De Mello, Seint Lwin, Joseph Sanderson, Jonathan Silk, Alex Tipping, Andrew Gerry, Phil Bassett, Karen Miller, Mark Dudley, Emily Schmidt

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A60; DOI: 10.1136/jitc-2020-SITC2020.0095
96 Decitabine gene modulation sensitizes human non–small cell lung cancer (NSCLC) to NY-ESO-1 TCR immunotherapy (letetresgene autoleucel; GSK3377794) in vivo
Dmitry Pankov, Ioanna Eleftheriadou, Anna Domogala, Sara Brett, Lea Patasic, Magdalena Kijewska, Gary Thripp, Jack Euesden, Jan Klapwijk, Katrina Soor, Miriam Damm, Mark D Hill, Mirella Georgouli, Aiman Shalabi, Cedrik Britten

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A60-A61; DOI: 10.1136/jitc-2020-SITC2020.0096
98 ATA3271: an armored, next-generation off-the-shelf, allogeneic, mesothelin-CAR T cell therapy for solid tumors
Jiangyue Liu, Xianhui Chen, Jason Karlen, Alfonso Brito, Tiffany Jheng, Philippe Foubert, Janani Krishnamurthy, Yannick Bulliard, Blake Aftab

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A61-A62; DOI: 10.1136/jitc-2020-SITC2020.0098
13 Use of anti-viral T cells to model HLA-restricted anti-tumor cytotoxic lymphocyte responses
Michael Overstreet, Vanessa Muniz-Medina, Ruoyan Chen, James Kurasawa, Stacy Kentner, Deepali Malhotra, Jane Osbourn, Jill Walker, Gordon Moody

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A7; DOI: 10.1136/jitc-2020-SITC2020.0013
66 Complex markers of survival from pembrolizumab: the potential predictive role of tumor mutational burden (TMB) and KRAS
Yong Hee Lee, Carrie Hoefer, Paul DePietro, Mary Nesline

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A71; DOI: 10.1136/jitc-2020-SITC2020.0066
116 Multi-antigen targeting of heterogenous solid tumors using CAR T cells secreting bi-specific T-cell engagers
Martin Hosking, Bishwas Shrestha, Megan Boyett, Soheila Shirinbak, Angela Gentile, Eric Sung, Yijia Pan, Tom Lee, Jason ORourke, Dan Shoemaker, Cokey Nguyen, Bahram Valamehr

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A71-A72; DOI: 10.1136/jitc-2020-SITC2020.0116

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