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1085 Innate immune activation by microtubule destabilizing agents enhances their efficacy in vivo, as predicted by machine learning analyses of human PBMC treated with a large, bioactive compound library
Hope O’Donnell, Matthew Booty, Ben Komalo, Sarah Headland, Lauren Nicolaisen, Brandon White, Christian Elabd

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1194; DOI: 10.1136/jitc-2023-SITC2023.1085
1086 Modulating the tumor microenvironment via hypoxia activated prodrug CPD100Li induced cell death synergistically enhances anti-CTLA-4 immunotherapy
August Sick

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1195; DOI: 10.1136/jitc-2023-SITC2023.1086
1087 SOT201 is a novel cis-acting immunocytokine targeting IL-15Rβγ to reinvigorate PD-1⁺tumor infiltrating lymphocytes and potentiate anti-tumor efficacy
Irena Adkins, Zuzana Antosova, Katerina Behalova, Petr Danek, Klara Danova, Matej Fabisik, Kamila Hladikova, Nataliia Kalynovska, Lucie Kosinova, Pavel Marasek, Vladyslav Mazhara, Nada Podzimkova, Jan Praslicka, Katerina Sajnerova, Milada Sirova, David Bechard, Ulrich Moebius, Marek Kovar, Lenka Palova Jelinkova, Radek Spisek, Martin Steegmaier

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1196; DOI: 10.1136/jitc-2023-SITC2023.1087
1088 Restoring immune fitness with oral Salmonella Typhi ZH9 to unlock the potential of cancer immunotherapies
Nicholas Glanville, Andrew Scott, Oluwatobiloba Oke, Claudia Prevosto, Livija Deban

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1197; DOI: 10.1136/jitc-2023-SITC2023.1088
1089 Local cancer immunotherapy with a mixture of cytokine-encoding mRNAs formulated in a novel lipoplex stimulates potent antitumor immune responses resulting in improved antitumor activity
Marie Bernardo, Timothy R Wagenaar, Hossam Hefesha, Virna Cortez-Retamozo, Mikhail Levit, Isaac Esparza, Ferdia Bates, Kerstin Andrea Heyl, Katalin Kariko, Donald Shaffer, Christian Hotz

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1198; DOI: 10.1136/jitc-2023-SITC2023.1089
1090 Enhancing DNA damage and micronuclei production in human cancer cell lines through radiotherapy-activated NBTXR3 nanoparticles
Celia Bienassis, Jordan Da Silva, Sebastien Paris

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1199; DOI: 10.1136/jitc-2023-SITC2023.1090
1091 Tigilanol Tiglate is a small molecule oncolytic that induces immunogenic cell death and promotes immune cell infiltration into human tumors
Jason K Cullen, Pei-Yi Yap, Blake Ferguson, Zara C Bruce, Motoko Koyama, Herlina Handoko, Jenny Johns, Praphaporn Stewart, Steven M Ogbourne, Paul W Reddell, Glen M Boyle, Peter G Parsons

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1200; DOI: 10.1136/jitc-2023-SITC2023.1091
1092 Induction of lysosomal membrane permeabilization by radiotherapy-activated NBTXR3 nanoparticles
Jordan Da Silva, Celia Bienassis, Sebastien Paris

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1201; DOI: 10.1136/jitc-2023-SITC2023.1092
1093 CLN-617 combines IL-2 and IL-12 in a single molecule to optimally balance safety and efficacy upon intratumoral injection
Naveen K Mehta, Kavya Rakhra, Kristan A Meetze, Irina M Shapiro, Laura Liu, K Dane Wittrup, Patrick A Baeuerle, Jennifer S Michaelson

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1202; DOI: 10.1136/jitc-2023-SITC2023.1093
1094 Collagen-anchored IL-2 and IL-12 cytokines potentiate anti-tumor immunity in advanced canine cancers
Jordan A Stinson, Matheus Moreno M Passos Barbosa, Allison Sheen, Jordan Hampel, Noor Momin, Elizabeth Fink, Rebecca Kamerer, Jonathan Samuelson, Rebecca Bernstein, Timothy Fan, K Dane Wittrup

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1203; DOI: 10.1136/jitc-2023-SITC2023.1094

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