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1117 Cellular mechanism of a synthetic star polymer platform for systemic STING agonist cancer immunotherapy
Qiuyin Ren, Yaling Zhu, Hojin Yoon, Sloane Fussell, David Wilson, Andrew Ishizuka, Geoffrey Lynn, Robert Seder

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1230; DOI: 10.1136/jitc-2023-SITC2023.1117
1118 The iodinated fluorescein derivative PV-10 enhances the antiviral activity of CD8+ T-Cells by inducing STING dimerization: implications for enhanced vaccine applications
Patrick Sipila, Satbir Thakur, Mehr Malhotra, Chunfen Zhang, Lian Willetts, Luis Murguia-Favela, Aru Narendran

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1231; DOI: 10.1136/jitc-2023-SITC2023.1118
1119 Selective reversal of key features of T cell exhaustion in an in vitro model by a SMARCA4/2 ATPase inhibitor
Eden Kleiman, Linda Liang, Jared Gunn, Mingfa Zang, Marrit Putker, Ludovic Bourre, Pirouz Daftarian

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1232; DOI: 10.1136/jitc-2023-SITC2023.1119
1120 Delivering TLR agonists in protein nanoparticle cancer vaccines reveals plasmacytoid dendritic cells (pDCs) support of myeloid dendritic cells (mDCs)
Nina Butkovich, Jo Anne Tucker, Aaron Ramirez, Enya Li, Vijaykumar S Meli, Edward L Nelson, Szu Wang

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1233; DOI: 10.1136/jitc-2023-SITC2023.1120
1121 TAC-003, a TLR9 agonist antibody conjugate for targeted immunotherapy of Nectin-4 expressing tumors
Amy Chen, Min Li, Emma RB Sangalang, Danielle Fontaine, Tiffany Chou, Mingrui An, Maja Bonacorsi, Bora Han, Hong I Wan, Maria Jose Costa, Pavel Strop

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1234; DOI: 10.1136/jitc-2023-SITC2023.1121
1122 Vidutolimod, an immunostimulatory virus-like particle, reduces proliferation but enhances the activation of tumor-specific T cells
Travis D Fischer, Caitlin D Lemke-Miltner, George J Weiner

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1235; DOI: 10.1136/jitc-2023-SITC2023.1122
1123 Checkpoint inhibitor administered either systemically or subcutaneously enhances the anti-tumor immunity of SD-101 delivered by PEDD device in treating liver metastasis
Chandra C Ghosh, Lauren Cournoyer, Jennie Yujia Liu, Alizee Ballarin, Prajna Guiha, Bryan Cox, Steven Katz

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1236; DOI: 10.1136/jitc-2023-SITC2023.1123
1124 Discovery and evaluation of bicyclic peptides as modulators of pattern recognition receptors
Laura L Goodfield, Robert P Hammer, Winston Lu, Katie Hill, Tamera Ashworth, Hannah S Gardner, Luca Mascheroni, Heather Scott, Tazmin Martin, Matthieu Masureel, Sandra Uhlenbroich, Rachel Dodds, Marta Amaral, Julia Kristenson, Gemma E Mudd, Liuhong Chen, Kevin McDonnell, Philip Brandish, Nicholas Keen

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1237; DOI: 10.1136/jitc-2023-SITC2023.1124
1125 In vitro characterization of cellular responses elicited by endosomal TLR agonists encapsulated in Qβ virus-like particles
MM Hasibuzzaman, Briana Ibarra, Ishrat Khan, Caitlin D Lemke-Miltner, George J Weiner, Andrean L Simons

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1238; DOI: 10.1136/jitc-2023-SITC2023.1125
1126 The micellar formulation of the TLR7 agonist MBS8(1V270) potentiates the effects of immune checkpoint inhibitors in vivo
Simon Jensen, Morten Just Petersen, Svetlana Panina

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1239; DOI: 10.1136/jitc-2023-SITC2023.1126

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