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1045 Overcoming immunosuppressive tumors by stimulating the adaptive and innate immune systems
Guillaume Carmona, Amanda Nash, Samira Aghlara-Fotovat, Ryan Newman, Jake Schladenhauffen, Suga Subramanian, Nick Luera, Steve Bonk, Maria Jarvis, Peter Rios, Rahul Sheth, Ravi Ghanta, Jose Oberholzer, Amir Jazaeri, Omid Veiseh

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1152; DOI: 10.1136/jitc-2023-SITC2023.1045
1046 A long-acting and Beta-intensified IL-2 analog, HM16390, significantly alters tumors to an immune favorable environment to potentiate PD-1 blockade
Jaehyuk Choi, Jinyoung Kim, Seongju Jeong, Yuyon Kim, Sang Hyun Park, Sungmin Bae, Daejin Kim, In Young Choi

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1153; DOI: 10.1136/jitc-2023-SITC2023.1046
1047 Protein design and inducible expression allow context-dependent, localized IL-12 activity to enhance solid tumor T cell therapies
Thaddeus M Davenport, Szu-han Huang, Howell Moffett, Brian D Weitzner, Luke Cassereau, Laura E Baker, Bradley Hammerson, Summer Zhuang, Christine Saechao, Lisa Song, Jade Mimms, David Chian, Candace Sims, Hajime Hiraragi, Marc J Lajoie, Bijan Boldajipour, Scott E Boyken

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1154; DOI: 10.1136/jitc-2023-SITC2023.1047
1048 AB821 is a CD8⁺ T cell selective IL-21 with enhanced bioavailability that reduces CD8⁺ T cell exhaustion to induce potent antitumor activity
Renee Greer, Arisa Paul, Jeffrey Houser, Audrey Hollingsworth, Wei Wei Prior, Manu Kumar, Ruth Lan, Yik Andy Yeung, Ivana Djuretic

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1155; DOI: 10.1136/jitc-2023-SITC2023.1048
1049 SHP-1 is a central mediator of GDF-15 mediated adhesion inhibition in T-cells
Markus Haake, Neha Vashist, Beatrice Haack, Birgitt Fischer, Kristin Eichler, Matthias Kist, Sabrina Genssler, Joerg Wischhusen, Eugen Leo, Christine Schuberth-Wagner

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1156; DOI: 10.1136/jitc-2023-SITC2023.1049
1050 Human stem cell derived dendritic cells provide a physiologically relevant system to evaluate the pharmacology of a FLT3L-Fc fusion protein for cancer immunotherapy
Dongping He, Anaïs Duval, Sarah Exbrayat, Meredith McLerie, Matthew Betzenhauser, Jérémie Decalf, Travis W Bainbridge, Christine Moussion, Christopher Kemball

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1157; DOI: 10.1136/jitc-2023-SITC2023.1050
1051 Noval IL-12 gene delivery vehicles for transformation of spontaneous canine soft-tissue sarcoma
Weiqing Jing, Himaly Shinglot, Juliana Chi Kei Ng, Ali Zhang, Rusul Al-Marayaty, Jennifer Wu, Jeffrey Bryan, Seth Pollack

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1158; DOI: 10.1136/jitc-2023-SITC2023.1051
1052 Durable anti-tumor effect induced by a long-acting and ‘beta-intensified’ IL-2 mutein, HM16390, in various immunological conditions
Jinyoung Kim, Jaehyuk Choi, Yuyon Kim, Seongju Jeong, Sang Hyun Park, Sungmin Bae, Daejin Kim, In Young Choi

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1159; DOI: 10.1136/jitc-2023-SITC2023.1052
1053 Preclinical pharmacodynamic characterization of STK-026: a novel IL-12 partial agonist for cancer with maintained CD8 T cell activity, reduced NK-mediated toxicity and an improved therapeutic window
Zhenya Koliesnik, Michael Totagrande, Ryan Burgess, Kim Q Tran, Michele Bauer, Bharghavi Jayaraman, Cindy Buffone, Priyanka Balasubrahmanyam, Jan Emmerich, Deepti Chaturvedi, Deepti Rokkam, Rene De Waal Malefyt, Heiko Greb, Navneet Ratti, Sandro Vivona, Robert Kastelein, Patrick Lupardus, Luis Zuniga, David B Rosen, Martin Oft

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1160; DOI: 10.1136/jitc-2023-SITC2023.1053
1054 Serum cytokine kinetics in C57BL/6 versus BALB/c mice upon Con A and LPS stimulation in vivo
Yi Li, Liping Feng, Dongxiao Feng, Jian Fei, Ruilin Sun, Xianfei X He

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1161; DOI: 10.1136/jitc-2023-SITC2023.1054

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