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1127 Combination of Toll-like receptor agonists and immune checkpoint blockade with anti-tumor vaccines can affect anti-tumor response
Donghwan Jeon, Douglas McNeel

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1240; DOI: 10.1136/jitc-2023-SITC2023.1127
1129 TLR2 and IFNγ synergize to enhance CXCL10 production, tumor-infiltrating lymphocytes, and growth control in triple negative breast cancer
Ileana S Mauldin, Marya E Dunlap-Brown, Melanie Rutkowski

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1241; DOI: 10.1136/jitc-2023-SITC2023.1129
1130 Design and characterization of novel TLR7-selective ligands with an automated screening platform
Diamanda Rigas, Emily Freund, Rebecca Leylek, Ann-Jay Tong, Anna-Maria Herzner, Shirley Ng Palace, Sara Wichner, Siri Tahtinen, Craig Blanchette, Benjamin Haley, Lélia Delamarre, Ira Mellman, Christopher Kemball

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1242; DOI: 10.1136/jitc-2023-SITC2023.1130
1131 Anti-CLEC2D-TLR9 agonist conjugate binds to and internalizes CLEC2D on myeloid cells, plasmacytoid DCs and B cells leading to robust TLR pathway activation and inflammatory cytokine production
Siamak Tabrizi, Vandana Nandivada, Frano Irvine, Caitlin Goshert, Kelly Nichols, Elizabeth Scanlon, Matthew Huggins, Heather Flick, Ming Tang, Seng-Lai Tan, Xianzhe Wang, Shruti Malu

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1243; DOI: 10.1136/jitc-2023-SITC2023.1131
1132 Stimulated tumor cells (STC) vaccine induce response in colorectal cancer
George Alzeeb, Lionel Chalus, Alban Bessede, Yan Wang, Arnaud Peyronnier, Corinne Tortorelli, Benoit Pinteur, Paul Bravetti, Antoine Italiano

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1244; DOI: 10.1136/jitc-2023-SITC2023.1132
1133 Characterization of CD4+ T cell responses against Rho C, a metastasis associated tumor antigen
Sara Fresnillo Saló, Anne Rahbech, Sara Pedersen, Juliane Schuhmacher, Cécile Gouttefangeas, Per thor Straten

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1245; DOI: 10.1136/jitc-2023-SITC2023.1133
1134 A novel mRNA therapeutic vaccine for polyomavirus associated merkel cell carcinoma
Alexander Frey, Curtis Perry, Kathryn Clulo, Kelly Olino, Jeffrey Ishizuka

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1246-A1248; DOI: 10.1136/jitc-2023-SITC2023.1134
1135 A novel self-assembling vaccine, VTX-067, targeting E6/E7 proteins of human papilloma virus induces T cell immune responses and inhibits HPV E6/E7 expressing tumor growth in a C57/B6 mouse model
Yohannes Gemechu, Sonia Mukherjee, Jeffrey A Gelfand, Timothy A Brauns, Ann E Sluder, Pierre R Leblanc, George Steinfels, Paul Korner, Ishan Kapila, Zachary Shriver, Patrick M Reeves, Mark C Poznansky

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1249; DOI: 10.1136/jitc-2023-SITC2023.1135
1136 Vaccine targeting of the tumor-associated antigen brachyury reduces development of colitis-induced colorectal lesions in the APC^Min/+ mouse model
Lucas A Horn, Haiyan Qin, Masafumi Iida, Kristen Fousek, Shantel Angstadt, John Greiner, Jeffrey Schlom, Claudia Palena

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1250; DOI: 10.1136/jitc-2023-SITC2023.1136
1137 MHC Class II peptide on a nanoparticle cancer vaccine induces anti-tumor immune responses
Enya Li, Nina Butkovich, Jo Anne Tucker, Edward L Nelson, Szu Wang

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1251; DOI: 10.1136/jitc-2023-SITC2023.1137

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