topic

1055 Heterodimeric Fc-fused IL12 shows potent antitumor activity and low toxicity
Wenting Liu, Dayan Zhang, Pengfei Zhou, Guodong Shen, Xiaoli Zeng, Weiming Zhou, Liansheng Cheng

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1162; DOI: 10.1136/jitc-2023-SITC2023.1055
1056 XTX301, a tumor activated, half-life extended IL-12 promoted potent anti-tumor immunity and activity across multiple syngeneic tumor models
Natalia V Malkova, Ekta Patel, Sallyann Vu, Damiano Fantini, Manoussa Fanny, Wilson Guzman, Stephanie Hsiao, Parker Johnson, Oleg Yerov, Kurt Jenkins, Hanumantha Rao Madala, Caitlin O’Toole, Jake Taylor, Magali Pederzoli-Ribeil, Ertan Eryilmaz, Benjamin Nicholson, Uli Bialucha, Jennifer O’Neil

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1163; DOI: 10.1136/jitc-2023-SITC2023.1056
1057 IL-37 dampens immune suppressive functions of MDSCs via metabolic reprogramming in the tumor microenvironment
Yu Mei, Ying Zhu, Kylie Su Mei Yong, Qingfeng Chen, Haiyan Liu

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1164; DOI: 10.1136/jitc-2023-SITC2023.1057
1058 Optimal antitumor immunity triggered by WTX-124, a clinical stage conditionally activated INDUKINE^TM molecule that releases fully potent IL-2 in the tumor microenvironment
Christopher J Nirschl, Heather R Brodkin, Daniel J Hicklin, Nesreen Ismail, Yuka Lewis, Cynthia Seidel-Dugan, Zoe Steuert, Jenna M Sullivan, William M Winston, Andres Salmeron

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1165; DOI: 10.1136/jitc-2023-SITC2023.1058
1059 Spatial analysis of tumor infiltrating lymphocyte populations in syngeneic mouse tumor models after treatment with IL-12 (mWTX-330) and IL-2 (WTX-124) INDUKINE^TM molecules
Christopher J Nirschl, Heather R Brodkin, Daniel J Hicklin, Cynthia Seidel-Dugan, Zoe Steuert, William M Winston, Andres Salmeron

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1166; DOI: 10.1136/jitc-2023-SITC2023.1059
1060 Optimally engineered IL18 Fc-fusion proteins balance potency and pharmacokinetics to promote strong anti-tumor activity
Alex Nisthal, Sung-Hyung Lee, Christine Bonzon, Ruschelle Love, Kendra N Avery, Rumana Rashid, Panida Lertkiatmongkol, Nicole Rodriguez, Irene Leung, Sher Karki, Norman J Barlow, Seung Y Chu, Gregory L Moore, John R Desjarlais

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1167; DOI: 10.1136/jitc-2023-SITC2023.1060
1061 The role of interleukin-9 in head and neck squamous cell carcinoma immune response and tumorigenesis
Sam Nusbaum, McKenzie Crist, Maria Lehn, Trisha Wise-Draper

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1168; DOI: 10.1136/jitc-2023-SITC2023.1061
1062 GI-102, a novel CD80-IgG4-IL2v3 fusion protein driving lymphocyte expansion and anti-cancer potential through regulation of immune cells in the tumor microenvironment
Min Park, Kayoung Shin, Seoho Kim, Haejong Lee, Yuseong Lee, Jisoo Kim, Eunjin Lee, Sungman Oh, Kyungwha Lee, Chong Woo Park, Jihyun Kim, Young Min Oh, Wonjae Lee, Yaein Amy Shim, Young-Gyu Cho, Young Jun Koh, Kookhwan Kim, Myoung Ho Jang

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1169; DOI: 10.1136/jitc-2023-SITC2023.1062
1063 Immune correlates with response in patients with metastatic solid tumors treated with a tumor targeting immunocytokine NHS-IL12
Stephanie C Pitts, Nicole J Toney, Margaret E Gatti-Mays, Nicholas P Tschernia, Julius Strauss, James L Gulley, Jeffrey Schlom, Renee N Donahue

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1170; DOI: 10.1136/jitc-2023-SITC2023.1063
1064 Characterization of preclinical anti-tumor and pharmacodynamic activity in response to conditionally active IFNa with or without checkpoint blockade
Benjamin Povinelli, Kamaljeet Kaur, Alexey Berezhnoy, Hsin Wang, Nicole Lapuyade, Carol LePage, Michael Winter, Olga Vasiljeva, Madan Paidhungat, Vangipuram Rangan, Erwan Le Scolan, Leila Boustany, Marcia Belvin, Dylan Daniel

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1171; DOI: 10.1136/jitc-2023-SITC2023.1064

Main menu

topic

Pages

Log in using your username and password

Main menu

Log in using your username and password

You are here

topic

Pages