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1106 Molecular mechanisms of immunogenic cell death driven by PT-112
Emma Guilbaud, Takahiro Yamazaki, Maria Congenie, Christina Yim, Tyler Ames, Lorenzo Galluzzi

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1218; DOI: 10.1136/jitc-2023-SITC2023.1106
1107 Enhancing immune responses to melanoma with the RIG-I antiviral pathway agonist SLR14
Curtis Perry, Alexander Frey, Wenyuan Ton, Maxine Mackie, Feriel Ouerghi, Jessica Wei, Kathryn Clulo, Mary He, Therese Cordero Dumit, Min Ding, Weiwei Guo, James Clune, Kelly Olino, Jeffrey Ishizuka

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1219; DOI: 10.1136/jitc-2023-SITC2023.1107
1109 Chemerin suppresses prostate tumor growth by modulating the recruitment of effector NK and CD8+ T-cells into the tumor microenvironment
Muhammad A Saeed, Bo Peng, Kevin Kim, Russell Pachynski

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1221; DOI: 10.1136/jitc-2023-SITC2023.1109
1110 Cell depleting agents assessment in preclinical models
Fabiane Sonego, Gaelle Martin, Alexis Gonon, Perrine Martin-Jeantet, Angela Pappalardo, Yacine Cherifi, Kader Thiam

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1222; DOI: 10.1136/jitc-2023-SITC2023.1110
1111 Targeting lipid metabolism to improve PARP inhibitor response in BRCA-associated TNBC
Carlos Wagner Wanderley, Daniel E Michaud, Kiran Kurmi, Adam Nelson, Kelly F Zheng, Shakchhi Joshi, Anita Mehta, Madeline G Townsend, Filipa Lynce, Geoffrey I Shapiro, Jessica Thaxton, Marcia Haigis, Jennifer L Guerriero

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1223; DOI: 10.1136/jitc-2023-SITC2023.1111
1112 Single-cell RNA sequencing reveals the positive feedback activation loop between T and dendritic cells induced by PD-L1x4–1BB bispecific antibody
Yunkai Zhang, Hui Yuwen, Gang Bian, Ao Sun, Linjie Tian, Jay Mei, Bo Shan, Bing Hou

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1224-A1225; DOI: 10.1136/jitc-2023-SITC2023.1112
1113 Payload screening identifies enhanced T cell responsiveness aimed for circAde, a circular RNA delivery system, towards treatment of solid tumors
Emelie Foord, Neshat Saffarzadeh, Eoghan T O’Leary, Sara Vikberg, Erik D Wiklund, Thomas B Hansen, Michael Uhlin, Thomas Poiret, Victor Levitsky

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1226; DOI: 10.1136/jitc-2023-SITC2023.1113
1114 Targeted delivery of a potent STING agonist payload via an antibody drug conjugate drives robust antitumor activity in preclinical models
Elizabeth Cummins, David Gruber, Weiping Zeng, Michelle L Ulrich, Kaleb Smith, Mallory Long, Kellie Spahr, Katie Snead, Katelyn Hinricher, Aditi Langalia, Priyanka Gupta, Alyson J Smith, Patrick Burke, Shyra Gardai, Peter Senter, Adam Hill, Elizabeth Gray

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1227; DOI: 10.1136/jitc-2023-SITC2023.1114
1115 A novel lioblastoma model resistant to both innate and adaptive immunotherapy
Spencer Lea, Jun Wei, Chao-Hsien Chen, Ivana William, Michael Curran

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1228; DOI: 10.1136/jitc-2023-SITC2023.1115
1116 VAX014 as a novel oncolytic agent for STING and RIG-I-positive solid tumors
Kinsey Nelson, Amanda Parikh, Shingo Tsuji, Katherine A Reil, Carrie D House, Kathleen L McGuire, Matthew Giacalone

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1229; DOI: 10.1136/jitc-2023-SITC2023.1116

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