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1279 H&E-2.0: an extended application of ST-net to liver cancer and its generalizability
Samuel Lee Cong, Bok Leong Chua, Felicia Wee, Chan Way Ng, Nicholas Da Zhi Ang, Thian Juea Reiner Sim, Chu Yuan, Menaka Priyadharsani Rajapakse, Solomonraj Wilson, Jeffrey Lim, Abu Bakr Bakr Azam, Yiyu Cai, Joe Yeong, Mai Chan Lau

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1417-A1419; DOI: 10.1136/jitc-2023-SITC2023.1279
1280 Modeling of direct (EGFR- based) and ADCC cytotoxic effect of Cetuximab on the basis of literature available in vitro data
Oleg Demin, Sergey Smirnov, Alexandra Diakonova, Anna Roskoshnaia, Gaurav Bajaj, Homer Adams, Manish Gupta, Craig Thalhauser

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1420; DOI: 10.1136/jitc-2023-SITC2023.1280
1281 Prediction of response to immunotherapy using machine learning and tumor kinetic modeling incorporating CD8 PET imaging analysis
Agnish Dey, Michael Ferris, Ian Wilson, William Le, Kristin Schmiedehausen, Kevin Maresca, Edmund Keliher, Jayant Narang, Ganesh M Mugundu, Aman Singh

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1421; DOI: 10.1136/jitc-2023-SITC2023.1281
1282 H&E 2.0 virtual staining of CD3⁺ T cells: improving cell labeling for precise model training
Xinyun Feng, Marcia Zhang, Willa Yim, Felicia Wee, Menaka Priyadharsani Rajapakse, Jeffrey Lim, Chan Way Ng, Inti Zlobec, Bernett Lee, Olaf Rotzchke, Joe Yeong, Mai Chan Lau

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1422-A1423; DOI: 10.1136/jitc-2023-SITC2023.1282
1283 A novel, scalable deep learning-based approach to automated quality control of multiplex immunofluorescence images
Annika F Fink, Roman Schulte-Sasse, Martin Bauw, Deepti Agrawal, Beatriz Perez, Mariam Sadeq, Hans Juergen Grote, Yae Ohata, Lukas Ruff, Maximilian Alber, Sharon Ruane, Thomas Mrowiec

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1424; DOI: 10.1136/jitc-2023-SITC2023.1283
1284 Computational approaches for metabolic target discovery in immuno-oncology
Linda E Fong, Meng Jin, Samir Kharbanda, Xiumin Wu, Marc Creixell, Benjamin Kaufmann-Malaga, Jonathan Powell

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1425; DOI: 10.1136/jitc-2023-SITC2023.1284
1285 Computational deconvolution identifies a Th2-enriched immune-inflammatory signature in invasive breast carcinoma
Mara Gilardi, Gilad Silberberg, Clare Killick-Cole, Haia Khouri, Stefano Cairo, Alex Moreau, Marianna Zipeto, Michael Ritchie

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1426; DOI: 10.1136/jitc-2023-SITC2023.1285
1286 A novel gene signature predicts immune infiltration phenotypes in humanized patient derived xenograft models
Mara Gilardi, Gilad Silberberg, Hsiu-Wen Tsai, Stefano Cairo, Christine Baer, Kurtis Cruz, Karin Abarca Heidemann, Maria Mancini, Marianna Zipeto, Michael Ritchie

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1427; DOI: 10.1136/jitc-2023-SITC2023.1286
1287 Comparison of multiplex immunofluorescence and H&E-based approaches for characterization of the tumor microenvironment
Fredrick D Gootkind, Xinwei Sher, Keith Steele, Florent Peyraud, Jean-Philippe Guégan, Antoine Italiano, Guy T Clifton, Laura A Dillon

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1428; DOI: 10.1136/jitc-2023-SITC2023.1287
1288 Characterization of tertiary lymphoid structure in pancreatic ductal adenocarcinoma tumors: insights from gene expression and pathology images, and identification using a deep learning approach
Meijian Guan, Anantharaman Muthuswamy, Susan Sun, Clifton Drew, Jenny Kaufmann, Merzu Belete, Sriram Sridhar, Brandon Higgs, Han Si

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1429; DOI: 10.1136/jitc-2023-SITC2023.1288

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