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1299 Radiomics features to predict tumor response and biomarker status in non-small cell lung cancer (NSCLC) patients treated with immunotherapy
Jeeyeon Lee, Maria Jose Aguilera Chuchuca, Peter Haseok Kim, Taegyu Um, Madeline Jenkin, Myungwoo Nam, Liam Il-Young Chung, Jisang Yu, Trie Arni Djunadi, Hyeonseon Kim, Moataz Soliman, Nicolo Gennaro, Leeseul Kim, Youjin Oh, Sung Mi Yoon, Zunairah Shah, Soowon Lee, Cecilia Nam, Timothy Hong, Yury S Velichko, Young Kwang Chae

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1444; DOI: 10.1136/jitc-2023-SITC2023.1299
1300 Prediction of efficacy and toxicities of immune checkpoint inhibitors using real-world patient data
Levente Lippenszky, Kathleen Mittendorf, Zoltan Kiss, Pablo Napan-Molina, Eszter Csernai, Michele LeNoue-Newton, Christine Micheel, Jan Wolber, Travis Osterman

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1445; DOI: 10.1136/jitc-2023-SITC2023.1300
1301 High-throughput analysis of immune biomarkers from brightfield whole tumor images using Indica Halo®
Jeff Lock, Nam Tran, James Hargrove, Ben Ovadia, Qingyan Au, Arezoo Hanifi

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1446; DOI: 10.1136/jitc-2023-SITC2023.1301
1302 A machine learning toolkit for automated processing of multiplexed immunofluorescence images
Monee McGrady, Matthew Bieniosek, Aaron Mayer, Alexandro E Trevino

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1447; DOI: 10.1136/jitc-2023-SITC2023.1302
1303 Spatial topic modeling of tumor microenvironment with multiplexed imaging
Xiyu Peng, James W Smithy, Nathaniel Aleynick, Mingqiang Zhuang, Yanyun Li, Jasme Lee, Andrea P Moy, Colleen Maher, Fiona Ehrich, Travis Hollmann, Margaret K Callahan, Katherine S Panageas, Ronglai Shen

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1448; DOI: 10.1136/jitc-2023-SITC2023.1303
1304 Robust machine learning (ML) approach for screening microbiome ecosystem therapies (MET) drug candidates in combination with immune checkpoint inhibitors
Emmanuel Prestat, Elsa Schalck, Antoine Bonnefoy, Antoine Sabourin, Cyrielle Gasc, Carole Schwintner, Nathalie Corvaia

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1449; DOI: 10.1136/jitc-2023-SITC2023.1304
1305 Agreement and reliability of an automated PD-L1 tumor proportion scoring algorithm in non-small cell lung cancer (NSCLC)
Daniela F Rodrigues, Christina Neppl, David Dorward, Tereza Losmanová, Rebecca Wyatt, Donna Mulkern, Samuel Pattle, Raphaël Oberson, Stefan Reinhard, Therese Waldburger, Inti Zlobec, Peter Caie

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1450; DOI: 10.1136/jitc-2023-SITC2023.1305
1306 Negative selection of ligand-receptor interactions mediating lymphocyte infiltration confers melanoma resistance to immune checkpoint blockade therapy by turning hot tumors to cold
Sahil Sahni, Kun Wang, Binbin Wang, Saugato R Dhruba, Di Wu, Matthew Nagy, Eytan Ruppin

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1451; DOI: 10.1136/jitc-2023-SITC2023.1306
1307 Development of a novel, cellular-level drug uptake quantification pipeline for accurate estimation of fluorescence-conjugated therapeutics: data from the phase 1b/2 open-label study ASP-1929–181
Shreya Sharma, Devraj Mandal, Myra E Gordon, Daniel De Magalhaes Filho, Amy H Thorne, Shantanu Majumdar

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1452; DOI: 10.1136/jitc-2023-SITC2023.1307
1308 Artificial intelligence (AI)-powered immune phenotyping based on programmed death ligand 1 (PD-L1) immunohistochemistry (IHC) in triple negative breast cancer (TNBC)
Sangwon Shin, Gahee Park, Soo Ick Cho, Taebum Lee, Juneyoung Ro, Seulki Kim, Seunghwan Shin, Aaron Valero, Seonwook Park, Biagio Brattoli, Jeongun Ryu, Changho Ahn, Siraj Ali, Chan-Young Ock

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1453; DOI: 10.1136/jitc-2023-SITC2023.1308

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