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Research ArticleNEURODEGENERATIVE DISORDER IMAGING

Clinical Role of Brain PET in Alzheimer Disease in the Era of Disease-Modifying Therapies

Ana M. Franceschi, Graham Keir, Tammie L.S. Benzinger, Petrice M. Cogswell, Farzana Z. Ali, Jeffrey R. Petrella, Jeffrey W. Prescott, Christopher T. Whitlow, Greg Zaharchuk, Jason W. Allen and on behalf of the American Society of Functional Neuroradiology (ASFNR)
American Journal of Neuroradiology July 2025, DOI: https://doi.org/10.3174/ajnr.A8738
Ana M. Franceschi
aFrom the Neuroradiology Division, Department of Radiology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell (A.M.F., G.K.), Lenox Hill Hospital, New York, New York
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  • ORCID record for Ana M. Franceschi
Graham Keir
aFrom the Neuroradiology Division, Department of Radiology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell (A.M.F., G.K.), Lenox Hill Hospital, New York, New York
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Tammie L.S. Benzinger
bMallinckrodt Institute of Radiology (T.L.S.B), Washington University in Saint Louis, St Louis, Missouri
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Petrice M. Cogswell
cDepartment of Radiology (P.M.C.), Mayo Clinic, Rochester, Minnesota
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Farzana Z. Ali
dDepartment of Molecular and Medical Pharmacology (F.Z.A.), University of California, Los Angeles, Los Angeles, California
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Jeffrey R. Petrella
eDivision of Neuroradiology, Department of Radiology (J.R.P.), Duke University School of Medicine, Durham, North Carolina
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Jeffrey W. Prescott
fDepartment of Radiology (J.W.P.), Case Western Reserve University MetroHealth Medical Center, Cleveland, Ohio
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Christopher T. Whitlow
gDepartment of Radiology (C.T.W.), Wake Forest University School of Medicine, Winston-Salem, North Carolina
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Greg Zaharchuk
hDepartment of Radiology (G.Z.), Stanford University, Stanford, California
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Jason W. Allen
iDepartment of Radiology and Imaging Sciences (J.W.A.), Indiana University School of Medicine, Indianapolis, Indiana
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Article Information

DOI 
https://doi.org/10.3174/ajnr.A8738
PubMed 
40639970

Published By 
American Journal of Neuroradiology
Print ISSN 
0195-6108
Online ISSN 
1936-959X
History 
  • Received August 16, 2024
  • Accepted after revision February 5, 2025
  • Published online July 10, 2025.

Copyright & Usage 
© 2025 by American Journal of Neuroradiology

Author Information

  1. Ana M. Franceschia,
  2. Graham Keira,
  3. Tammie L.S. Benzingerb,
  4. Petrice M. Cogswellc,
  5. Farzana Z. Alid,
  6. Jeffrey R. Petrellae,
  7. Jeffrey W. Prescottf,
  8. Christopher T. Whitlowg,
  9. Greg Zaharchukh,
  10. Jason W. Alleni,
  11. on behalf of the American Society of Functional Neuroradiology (ASFNR)
  1. aFrom the Neuroradiology Division, Department of Radiology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell (A.M.F., G.K.), Lenox Hill Hospital, New York, New York
  2. bMallinckrodt Institute of Radiology (T.L.S.B), Washington University in Saint Louis, St Louis, Missouri
  3. cDepartment of Radiology (P.M.C.), Mayo Clinic, Rochester, Minnesota
  4. dDepartment of Molecular and Medical Pharmacology (F.Z.A.), University of California, Los Angeles, Los Angeles, California
  5. eDivision of Neuroradiology, Department of Radiology (J.R.P.), Duke University School of Medicine, Durham, North Carolina
  6. fDepartment of Radiology (J.W.P.), Case Western Reserve University MetroHealth Medical Center, Cleveland, Ohio
  7. gDepartment of Radiology (C.T.W.), Wake Forest University School of Medicine, Winston-Salem, North Carolina
  8. hDepartment of Radiology (G.Z.), Stanford University, Stanford, California
  9. iDepartment of Radiology and Imaging Sciences (J.W.A.), Indiana University School of Medicine, Indianapolis, Indiana
  1. Please address correspondence to Ana M. Franceschi, MD, PhD, Department of Radiology, Lenox Hill Hospital, 100 East 77th St, 3rd Floor, New York, NY, 10075; e-mail: afranceschi{at}northwell.edu; @AFrances_MDPhD
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Cite this article
Ana M. Franceschi, Graham Keir, Tammie L.S. Benzinger, Petrice M. Cogswell, Farzana Z. Ali, Jeffrey R. Petrella, Jeffrey W. Prescott, Christopher T. Whitlow, Greg Zaharchuk, Jason W. Allen, on behalf of the American Society of Functional Neuroradiology (ASFNR)
Clinical Role of Brain PET in Alzheimer Disease in the Era of Disease-Modifying Therapies
American Journal of Neuroradiology Jul 2025, DOI: 10.3174/ajnr.A8738

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Role of Brain PET in Alzheimer's Disease
Ana M. Franceschi, Graham Keir, Tammie L.S. Benzinger, Petrice M. Cogswell, Farzana Z. Ali, Jeffrey R. Petrella, Jeffrey W. Prescott, Christopher T. Whitlow, Greg Zaharchuk, Jason W. Allen, on behalf of the American Society of Functional Neuroradiology (ASFNR)
American Journal of Neuroradiology Jul 2025, DOI: 10.3174/ajnr.A8738
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    • SUMMARY:
    • ABBREVIATIONS:
    • CLINCIAL AMYLOID PET
    • CLINICAL τ PET
    • WORKFLOW/CONSISTENCY
    • FLUID BIOMARKERS
    • CLINICAL MRI FOR THE SURVEILLANCE OF ANTIAMYLOID THERAPY
    • LIMITATIONS
    • CONCLUSIONS
    • Footnotes
    • References
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