More articles from NEURODEGENERATIVE DISORDER IMAGING
- Antiamyloid Therapy and Cerebral Blood Flow Changes on MRI: A Potential Longitudinal Biomarker of Treatment Response?
AD is characterized by the accumulation of extracellular amyloid-β in the brain parenchyma and along the walls of cerebral blood vessels, leading to decreased CBF. CBF changes on ASL-MR could reflect clearance of amyloid-β on lecanemab therapy, raising the possibility that ASL-MR could serve as a tool for monitoring the neurovascular treatment response.
- Clinical Improvement after Shunt Surgery in Patients with Idiopathic Normal Pressure Hydrocephalus Can Be Quantified by Diffusion Tensor Imaging
This study investigated DTI parameter alterations in pre- and postshunt implantation in patients with iNPH and the relationship between DTI parameters and clinical improvement. Cognitive domain improvement after surgery correlated with preoperative DTI values of cingulate gyrus, uncinate fasciculus, superior longitudinal fasciculus, or corpus callosum, which are regions involved in memory and psychomotor speed processes.