Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleAdult Brain
Open Access

Dual-Layer Detector Cone-Beam CT Angiography for Stroke Assessment: First-in-Human Results (the Next Generation X-ray Imaging System Trial)

F. Ståhl, H. Almqvist, J. Kolloch, Å. Aspelin, V. Gontu, E. Hummel, M. van Vlimmeren, M. Simon, A. Thran, Å. Holmberg, M.V. Mazya, M. Söderman and A.F. Delgado
American Journal of Neuroradiology April 2023, DOI: https://doi.org/10.3174/ajnr.A7835
F. Ståhl
aFrom the Departments of Neuroradiology (F.S., H.A., J.K., Å.A., V.G., Å.H., M. Söderman, A.F.D.)
cDepartment of Clinical Neuroscience (F.S., H.A., V.G., M.V.M., M. Söderman, A.F.D.) Karolinska Institutet, Stockholm, Sweden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for F. Ståhl
H. Almqvist
aFrom the Departments of Neuroradiology (F.S., H.A., J.K., Å.A., V.G., Å.H., M. Söderman, A.F.D.)
cDepartment of Clinical Neuroscience (F.S., H.A., V.G., M.V.M., M. Söderman, A.F.D.) Karolinska Institutet, Stockholm, Sweden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for H. Almqvist
J. Kolloch
aFrom the Departments of Neuroradiology (F.S., H.A., J.K., Å.A., V.G., Å.H., M. Söderman, A.F.D.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for J. Kolloch
Å. Aspelin
aFrom the Departments of Neuroradiology (F.S., H.A., J.K., Å.A., V.G., Å.H., M. Söderman, A.F.D.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Å. Aspelin
V. Gontu
aFrom the Departments of Neuroradiology (F.S., H.A., J.K., Å.A., V.G., Å.H., M. Söderman, A.F.D.)
cDepartment of Clinical Neuroscience (F.S., H.A., V.G., M.V.M., M. Söderman, A.F.D.) Karolinska Institutet, Stockholm, Sweden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for V. Gontu
E. Hummel
dImage Guided Therapy (E.H., M.v.V.), Phillips Healthcare, Best, the Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for E. Hummel
M. van Vlimmeren
dImage Guided Therapy (E.H., M.v.V.), Phillips Healthcare, Best, the Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for M. van Vlimmeren
M. Simon
ePhilips Research Hamburg (M. Simon, A.T.), Hamburg, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for M. Simon
A. Thran
ePhilips Research Hamburg (M. Simon, A.T.), Hamburg, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for A. Thran
Å. Holmberg
aFrom the Departments of Neuroradiology (F.S., H.A., J.K., Å.A., V.G., Å.H., M. Söderman, A.F.D.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Å. Holmberg
M.V. Mazya
bNeurology (M.V.M.), Karolinska University Hospital, Stockholm, Sweden
cDepartment of Clinical Neuroscience (F.S., H.A., V.G., M.V.M., M. Söderman, A.F.D.) Karolinska Institutet, Stockholm, Sweden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for M.V. Mazya
M. Söderman
aFrom the Departments of Neuroradiology (F.S., H.A., J.K., Å.A., V.G., Å.H., M. Söderman, A.F.D.)
cDepartment of Clinical Neuroscience (F.S., H.A., V.G., M.V.M., M. Söderman, A.F.D.) Karolinska Institutet, Stockholm, Sweden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for M. Söderman
A.F. Delgado
aFrom the Departments of Neuroradiology (F.S., H.A., J.K., Å.A., V.G., Å.H., M. Söderman, A.F.D.)
cDepartment of Clinical Neuroscience (F.S., H.A., V.G., M.V.M., M. Söderman, A.F.D.) Karolinska Institutet, Stockholm, Sweden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for A.F. Delgado
  • Article
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

References

  1. 1.↵
    1. Jaffray DA,
    2. Siewerdsen JH
    . Cone-beam computed tomography with a flat-panel imager: initial performance characterization. Med Phys 2000;27:1311–23 doi:10.1118/1.599009 pmid:10902561
    CrossRefPubMedWeb of Science
  2. 2.↵
    1. Soderman M,
    2. Babic D,
    3. Holmin S, et al
    . Brain imaging with a flat detector C-arm: Technique and clinical interest of XperCT. Neuroradiology 2008;50:863–68 doi:10.1007/s00234-008-0419-1 pmid:18560818
    CrossRefPubMedWeb of Science
  3. 3.↵
    1. Dijkstra ML,
    2. Eagleton MJ,
    3. Greenberg RK, et al
    . Intraoperative C-arm cone-beam computed tomography in fenestrated/branched aortic endografting. J Vasc Surg 2011;53:583–90 doi:10.1016/j.jvs.2010.09.039 pmid:21129898
    CrossRefPubMed
  4. 4.↵
    1. Tacher V,
    2. Radaelli A,
    3. Lin M, et al
    . How I do it: cone-beam CT during transarterial chemoembolization for liver cancer. Radiology 2015;274:320–34 doi:10.1148/radiol.14131925 pmid:25625741
    CrossRefPubMed
  5. 5.↵
    1. Doerfler A,
    2. Golitz P,
    3. Engelhorn T, et al
    . Flat-panel computed tomography (DYNA-CT) in neuroradiology: from high-resolution imaging of implants to one-stop-shopping for acute stroke. Clin Neuroradiol 2015;25 Suppl 2:291–97 doi:10.1007/s00062-015-0423-x pmid:26091842
    CrossRefPubMed
  6. 6.↵
    1. Brehm A,
    2. Tsogkas I,
    3. Maier IL, et al
    . One-stop management with perfusion for transfer patients with stroke due to a large-vessel occlusion: feasibility and effects on in-hospital times. AJNR J Neuroradiol 2019;40:1330–34 doi:10.3174/ajnr.A6129 pmid:31296523
    Abstract/FREE Full Text
  7. 7.↵
    1. Struffert T,
    2. Deuerling-Zheng Y,
    3. Kloska S, et al
    . Flat detector CT in the evaluation of brain parenchyma, intracranial vasculature, and cerebral blood volume: a pilot study in patients with acute symptoms of cerebral ischemia. AJNR Am J Neuroradiol 2010;31:1462–69 doi:10.3174/ajnr.A2083 pmid:20378700
    Abstract/FREE Full Text
  8. 8.↵
    1. Struffert T,
    2. Deuerling-Zheng Y,
    3. Kloska S, et al
    . Dynamic angiography and perfusion imaging using flat detector CT in the angiography suite: a pilot study in patients with acute middle cerebral artery occlusions. AJNR Am J Neuroradiol 2015;36:1964–70 doi:10.3174/ajnr.A4383 pmid:26066625
    Abstract/FREE Full Text
  9. 9.↵
    1. Saake M,
    2. Breuer L,
    3. Goelitz P, et al
    . Flat detector computed tomography angiography with intravenous contrast application: feasibility for visualization of cerebral arterial vasculature. J Neuroimaging 2013;23:414–20 doi:10.1111/j.1552-6569.2012.00762.x pmid:23279381
    CrossRefPubMed
  10. 10.↵
    1. Hoelter P,
    2. Goelitz P,
    3. Lang S, et al
    . Visualization of large vessel occlusion, clot extent, and collateral supply using volume perfusion flat detector computed tomography in acute patients with stroke. Acta Radiol 2019;60:1504–11 doi:10.1177/0284185119836220 pmid:30862169
    CrossRefPubMed
  11. 11.↵
    1. Schneider D,
    2. Apfaltrer P,
    3. Sudarski S, et al
    . Optimization of kiloelectron volt settings in cerebral and cervical dual-energy CT angiography determined with virtual monoenergetic imaging. Acad Radiol 2014;21:431–36 doi:10.1016/j.acra.2013.12.006 pmid:24594412
    CrossRefPubMed
  12. 12.↵
    1. Leithner D,
    2. Mahmoudi S,
    3. Wichmann JL, et al
    . Evaluation of virtual monoenergetic imaging algorithms for dual-energy carotid and intracerebral CT angiography: effects on image quality, artefacts and diagnostic performance for the detection of stenosis. Eur J Radiol 2018;99:111–17 doi:10.1016/j.ejrad.2017.12.024 pmid:29362140
    CrossRefPubMed
  13. 13.↵
    1. Neuhaus V,
    2. Große Hokamp N,
    3. Abdullayev N, et al
    . Comparison of virtual monoenergetic and polyenergetic images reconstructed from dual-layer detector CT angiography of the head and neck. Eur Radiol 2018;28:1102–10 doi:10.1007/s00330-017-5081-8 pmid:29018958
    CrossRefPubMed
  14. 14.↵
    1. Fredenberg E
    . Spectral and dual-energy X-ray imaging for medical applications. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 2018;878:74–87 doi:10.1016/j.nima.2017.07.044
    CrossRef
  15. 15.↵
    1. Ståhl F,
    2. Schäfer D,
    3. Omar A, et al
    . Performance characterization of a prototype dual-layer cone-beam computed tomography system. Med Phys 2021;48:6740–54 doi:10.1002/mp.15240 pmid:34622973
    CrossRefPubMed
  16. 16.↵
    1. Keselman B,
    2. Berglund A,
    3. Ahmed N, et al
    . The Stockholm Stroke Triage Project: outcomes of endovascular thrombectomy before and after triage implementation. Stroke 2022;53:473–81 doi:10.1161/STROKEAHA.121.034195 pmid:34583527
    CrossRefPubMed
  17. 17.↵
    1. Brown KM,
    2. Zabic S,
    3. Shechter G
    . Impact of spectral separation in dual-energy CT with anti-correlated statistical reconstruction. Proceedings of the Fully Three-Dimensional Image Reconstruction in Radiology and Nuclear Medicine, Worcester, Massachusetts. July 2, 2015:491–94
  18. 18.↵
    1. Zopfs D,
    2. Lennartz S,
    3. Abdullayev N, et al
    . Generally applicable window settings of low-keV virtual monoenergetic reconstructions in dual-layer CT-angiography of the head and neck. Quant Imaging Med Surg 2021;11:3408–17 doi:10.21037/qims-20-1140 pmid:34341719
    CrossRefPubMed
  19. 19.↵
    1. Hinkmann FM,
    2. Voit HL,
    3. Anders K, et al
    . Ultra-fast carotid CT-angiography: low versus standard volume contrast material protocol for a 128-slice CT-system. Invest Radiol 2009;44:257–64 doi:10.1097/RLI.0b013e31819b08a0 pmid:19550377
    CrossRefPubMed
  20. 20.↵
    1. Mantel N,
    2. Haenszel W
    . Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 1959;22:719–48 pmid:13655060
    CrossRefPubMedWeb of Science
  21. 21.↵
    1. Fleiss JL
    . Measuring nominal scale agreement among many raters. Psychol Bull 1971;76:378–82 doi:10.1037/h0031619
    CrossRef
  22. 22.↵
    1. Cancelliere NM,
    2. Hummel E,
    3. van Nijnatten F, et al
    . The butterfly effect: improving brain cone-beam CT image artifacts for stroke assessment using a novel dual-axis trajectory. J Neurointerv Surg 2023;15;283–87 doi:10.1136/neurintsurg-2021-018553 pmid:35478176
    Abstract/FREE Full Text
  23. 23.↵
    1. Leyhe JR,
    2. Tsogkas I,
    3. Hesse AC, et al
    . Latest generation of flat detector CT as a peri-interventional diagnostic tool: a comparative study with multidetector CT. J Neurointerv Surg 2017;9:1253–57 doi:10.1136/neurintsurg-2016-012866 pmid:27998955
    Abstract/FREE Full Text
  24. 24.↵
    1. Ouadah S,
    2. Jacobson M,
    3. Stayman JW, et al
    . Correction of patient motion in cone-beam CT using 3D–2D registration. Phys Med Biol 2017;62:8813–31 doi:10.1088/1361-6560/aa9254 pmid:28994668
    CrossRefPubMed
  25. 25.↵
    1. Li Y,
    2. Garrett JW,
    3. Li K, et al
    . Time-resolved C-arm cone beam CT angiography (TR-CBCTA) imaging from a single short-scan C-arm cone beam CT acquisition with intra-arterial contrast injection. Phys Med Biol 2018;63:075001 doi:10.1088/1361-6560/aab346 pmid:29494345
    CrossRefPubMed
  26. 26.
    American Association of Physicists in Medicine. Report of American Association of Physicists in Medicine Task Group 111: The Future of CT Dosimetry: Comprehensive Methodology for the Evaluation of Radiation Dose in X-Ray Computed Tomography (2010). https://www.aapm.org/pubs/reports/detail.asp?docid=109. Accessed September 6, 2022
PreviousNext
Back to top
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Dual-Layer Detector Cone-Beam CT Angiography for Stroke Assessment: First-in-Human Results (the Next Generation X-ray Imaging System Trial)
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
F. Ståhl, H. Almqvist, J. Kolloch, Å. Aspelin, V. Gontu, E. Hummel, M. van Vlimmeren, M. Simon, A. Thran, Å. Holmberg, M.V. Mazya, M. Söderman, A.F. Delgado
Dual-Layer Detector Cone-Beam CT Angiography for Stroke Assessment: First-in-Human Results (the Next Generation X-ray Imaging System Trial)
American Journal of Neuroradiology Apr 2023, DOI: 10.3174/ajnr.A7835

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Dual-Layer Detector Cone-Beam CT Angiography for Stroke Assessment: First-in-Human Results (the Next Generation X-ray Imaging System Trial)
F. Ståhl, H. Almqvist, J. Kolloch, Å. Aspelin, V. Gontu, E. Hummel, M. van Vlimmeren, M. Simon, A. Thran, Å. Holmberg, M.V. Mazya, M. Söderman, A.F. Delgado
American Journal of Neuroradiology Apr 2023, DOI: 10.3174/ajnr.A7835
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • MATERIALS AND METHODS
    • RESULTS
    • DISCUSSION
    • CONCLUSIONS
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Crossref (2)
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Cerebral perfusion simulation using realistically generated synthetic trees for healthy and stroke patients
    Hans Christian Rundfeldt, Chang Min Lee, Hanyoung Lee, Keun-Hwa Jung, Hyeyeon Chang, Hyun Jin Kim
    Computer Methods and Programs in Biomedicine 2024 244
  • Stroke Evaluation in the Interventional Suite Using Dual-Layer Detector Cone-Beam CT: a First-in-human Prospective Cohort Study (the Next Generation X-ray Imaging System Trial)
    Fredrik Ståhl, Håkan Almqvist, Åsa Aspelin, Jens Kolloch, Odett Ghalamkari, Vamsi Gontu, Dirk Schäfer, Peter van de Haar, Klaus-Jürgen Engel, Fred van Nijnatten, Åke Holmberg, Michael V. Mazya, Michael Söderman, Anna Falk Delgado
    Clinical Neuroradiology 2024 34 4

More in this TOC Section

  • Diagnostic Neuroradiology of Monoclonal Antibodies
  • Clinical Outcomes After Chiari I Decompression
  • Segmentation of Brain Metastases with BLAST
Show more Adult Brain

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire