Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticlePediatric Neuroimaging
Open Access

White Matter Injury and Structural Anomalies in Infants with Prenatal Opioid Exposue

S.L. Merhar, N.A. Parikh, A. Braimah, B.B. Poindexter, J. Tkach and B. Kline-Fath
American Journal of Neuroradiology October 2019, DOI: https://doi.org/10.3174/ajnr.A6282
S.L. Merhar
aFrom the Perinatal Institute, Division of Neonatology (S.L.M., N.A.P., B.B.P.)
dDepartment of Pediatrics (S.L.M., N.A.P., B.B.P.), University of Cincinnati College of Medicine, Cincinnati, Ohio.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for S.L. Merhar
N.A. Parikh
aFrom the Perinatal Institute, Division of Neonatology (S.L.M., N.A.P., B.B.P.)
dDepartment of Pediatrics (S.L.M., N.A.P., B.B.P.), University of Cincinnati College of Medicine, Cincinnati, Ohio.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for N.A. Parikh
A. Braimah
bPediatric Neuroimaging Research Consortium (A.B.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for A. Braimah
B.B. Poindexter
aFrom the Perinatal Institute, Division of Neonatology (S.L.M., N.A.P., B.B.P.)
dDepartment of Pediatrics (S.L.M., N.A.P., B.B.P.), University of Cincinnati College of Medicine, Cincinnati, Ohio.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for B.B. Poindexter
J. Tkach
cDepartment of Radiology (J.T., B.K.-F.), Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for J. Tkach
B. Kline-Fath
cDepartment of Radiology (J.T., B.K.-F.), Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for B. Kline-Fath
  • Article
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

Article Information

DOI 
https://doi.org/10.3174/ajnr.A6282
PubMed 
31624119

Published By 
American Journal of Neuroradiology
Print ISSN 
0195-6108
Online ISSN 
1936-959X
History 
  • Received July 1, 2019
  • Accepted after revision September 3, 2019
  • Published online October 17, 2019.

Article Versions

  • You are currently viewing a Latest version of this article (October 17, 2019 - 07:31).
  • View the most recent version of this article
Copyright & Usage 
© 2019 by American Journal of Neuroradiology Indicates open access to non-subscribers at www.ajnr.org

Author Information

  1. S.L. Merhara,d,
  2. N.A. Parikha,d,
  3. A. Braimahb,
  4. B.B. Poindextera,d,
  5. J. Tkachc and
  6. B. Kline-Fathc
  1. aFrom the Perinatal Institute, Division of Neonatology (S.L.M., N.A.P., B.B.P.)
  2. bPediatric Neuroimaging Research Consortium (A.B.)
  3. cDepartment of Radiology (J.T., B.K.-F.), Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
  4. dDepartment of Pediatrics (S.L.M., N.A.P., B.B.P.), University of Cincinnati College of Medicine, Cincinnati, Ohio.
  1. Please address correspondence to Stephanie L. Merhar, MD, MS, Cincinnati Children's Hospital, Division of Neonatology, 3333 Burnet Ave ML 7009, Cincinnati OH 45229; e-mail: Stephanie.merhar{at}cchmc.org
View Full Text

Funding

  • National Center for Advancing Translational Sciences

    KL2 TR1426

Altmetrics

Cited By...

  • 20 Citations
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • The immediate and long-term effects of prenatal opioid exposure
    Elizabeth Yen, Jonathan M. Davis
    Frontiers in Pediatrics 2022 10
  • Global Brain Functional Network Connectivity in Infants With Prenatal Opioid Exposure
    Rupa Radhakrishnan, Ramana V. Vishnubhotla, Yi Zhao, Jingwen Yan, Bing He, Nicole Steinhardt, David M. Haas, Gregory M. Sokol, Senthilkumar Sadhasivam
    Frontiers in Pediatrics 2022 10
  • A Holistic Systems Approach to Characterize the Impact of Pre- and Post-natal Oxycodone Exposure on Neurodevelopment and Behavior
    Katherine E. Odegaard, Victoria L. Schaal, Alexander R. Clark, Sneh Koul, Jagadesan Sankarasubramanian, Zhiqiu Xia, Melissa Mellon, Mariano Uberti, Yutong Liu, Andrew Stothert, Matthew Van Hook, Hanjun Wang, Chittibabu Guda, Steven J. Lisco, Gurudutt Pendyala, Sowmya V. Yelamanchili
    Frontiers in Cell and Developmental Biology 2021 8
  • Alterations of brain microstructures in a mouse model of prenatal opioid exposure detected by diffusion MRI
    Gregory G. Grecco, Syed Salman Shahid, Brady K. Atwood, Yu-Chien Wu
    Scientific Reports 2022 12 1
  • In utero methadone exposure permanently alters anatomical and functional connectivity: A preclinical evaluation
    Eric M. Chin, Yuma Kitase, Nethra K. Madurai, Shenandoah Robinson, Lauren L. Jantzie
    Frontiers in Pediatrics 2023 11
  • Thalamocortical functional connectivity in infants with prenatal opioid exposure correlates with severity of neonatal opioid withdrawal syndrome
    Rupa Radhakrishnan, Ramana V. Vishnubhotla, Zoe Guckien, Yi Zhao, Gregory M. Sokol, David M. Haas, Senthilkumar Sadhasivam
    Neuroradiology 2022 64 8
  • Co-occurrence of preconception maternal childhood adversity and opioid use during pregnancy: Implications for offspring brain development
    Madeleine C. Allen, Nora K. Moog, Claudia Buss, Elizabeth Yen, Hanna C. Gustafsson, Elinor L. Sullivan, Alice M. Graham
    Neurotoxicology and Teratology 2021 88
  • A review of the genomics of neonatal abstinence syndrome
    Elizabeth Yen, Nathan Gaddis, Lauren Jantzie, Jonathan M. Davis
    Frontiers in Genetics 2023 14
  • Cerebral perfusion and neurological examination characterise neonatal opioid withdrawal syndrome: a prospective cohort study
    Kristen L Benninger, Jin Peng, Mai-Lan Ho, Julia Newton, Danny J J Wang, Houchun H Hu, Ann R Stark, Jerome A Rusin, Nathalie L Maitre
    Archives of Disease in Childhood - Fetal and Neonatal Edition 2022 107 4
  • Sex differences in neonatal outcomes following prenatal opioid exposure
    Nethra K. Madurai, Lauren L. Jantzie, Elizabeth Yen
    Frontiers in Pediatrics 2024 12
  • DTI of Opioid-Exposed Fetuses Using ComBat Harmonization: A Bi-Institutional Study
    J.A. Dudley, U.D. Nagaraj, S. Merhar, F.T. Mangano, B.M. Kline-Fath, X. Ou, A. Acheson, W. Yuan
    American Journal of Neuroradiology 2023 44 9
  • Methadone directly impairs central nervous system cells in vitro
    Cristian De Gregorio, Javiera Gallardo, Pablo Berríos-Cárcamo, Álex Handy, Daniela Santapau, Antonia González-Madrid, Marcelo Ezquer, Paola Morales, Alejandro Luarte, Daniela Corvalán, Úrsula Wyneken, Fernando Ezquer
    Scientific Reports 2024 14 1
  • A Prospective Multi-Institutional Study Comparing the Brain Development in the Third Trimester between Opioid-Exposed and Nonexposed Fetuses Using Advanced Fetal MR Imaging Techniques
    Hyuk Jin Yun, Usha D. Nagaraj, P. Ellen Grant, Stephanie L. Merhar, Xiawei Ou, Weili Lin, Ashley Acheson, Karen Grewen, Beth M. Kline-Fath, Kiho Im
    American Journal of Neuroradiology 2024 45 2
  • Children had smaller brain volumes and cortical surface areas after prenatal opioid maintenance therapy exposure
    Anne Kathinka Aslaksen, Knut Jørgen Bjuland, Mari Leirdal Hoem, Gro Horgen, Olav H. Haugen, Jon Skranes, Stein Magnus Aukland
    Acta Paediatrica 2025 114 2
  • Use of Phenobarbital to Treat Neonatal Abstinence Syndrome From Exposure to Single vs. Multiple Substances
    Alla Kushnir, Cynthia Garretson, Maheswari Mariappan, Gary Stahl
    Frontiers in Pediatrics 2022 9
  • Jecenia Duran, Sonia Khalid, Lauren Richardson, Kelly Bosse, Susanne Brummelte
    2025
  • Handbook of the Biology and Pathology of Mental Disorders
    Himanshu Kaulas, Amit M. Mathur
    2025
  • Opioid exposure in gestation, postnatal adversity, and preschool-age cognitive functioning
    Sanjana Ravi, Andrew E. Molnar, Emilia F. Cárdenas, Autumn Kujawa, Kathryn L. Humphreys
    International Journal of Behavioral Development 2025 49 2
  • Regional analysis of myelin basic protein across postnatal brain development of C57BL/6J mice
    Siddhi S. Ozarkar, Ridthi K. R. Patel, Tasmai Vulli, Carlee A. Friar, Alain C. Burette, Benjamin D. Philpot
    Frontiers in Neuroanatomy 2025 19
  • The impact of socio-environmental factors on brain structure over the early life course of preterm-born individuals - A systematic review
    Taylor Barda, Benita Schmitz-Koep, Aurore Menegaux, Peter Bartmann, Dieter Wolke, Christian Sorg, Dennis M Hedderich
    Neuroscience & Biobehavioral Reviews 2025 170
PreviousNext
Back to top
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
White Matter Injury and Structural Anomalies in Infants with Prenatal Opioid Exposue
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
S.L. Merhar, N.A. Parikh, A. Braimah, B.B. Poindexter, J. Tkach, B. Kline-Fath
White Matter Injury and Structural Anomalies in Infants with Prenatal Opioid Exposue
American Journal of Neuroradiology Oct 2019, DOI: 10.3174/ajnr.A6282

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
White Matter Injury and Structural Anomalies in Infants with Prenatal Opioid Exposue
S.L. Merhar, N.A. Parikh, A. Braimah, B.B. Poindexter, J. Tkach, B. Kline-Fath
American Journal of Neuroradiology Oct 2019, DOI: 10.3174/ajnr.A6282
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • MATERIALS AND METHODS
    • RESULTS
    • DISCUSSION
    • CONCLUSIONS
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • A Prospective Multi-Institutional Study Comparing the Brain Development in the Third Trimester between Opioid-Exposed and Nonexposed Fetuses Using Advanced Fetal MR Imaging Techniques
  • DTI of Opioid-Exposed Fetuses Using ComBat Harmonization: A Bi-Institutional Study
  • Cerebral perfusion and neurological examination characterise neonatal opioid withdrawal syndrome: a prospective cohort study
  • In utero exposure to morphine leads to sex-specific behavioral alterations that persist into adulthood in cross-fostered mice
  • Crossref (20)
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • The immediate and long-term effects of prenatal opioid exposure
    Elizabeth Yen, Jonathan M. Davis
    Frontiers in Pediatrics 2022 10
  • Global Brain Functional Network Connectivity in Infants With Prenatal Opioid Exposure
    Rupa Radhakrishnan, Ramana V. Vishnubhotla, Yi Zhao, Jingwen Yan, Bing He, Nicole Steinhardt, David M. Haas, Gregory M. Sokol, Senthilkumar Sadhasivam
    Frontiers in Pediatrics 2022 10
  • A Holistic Systems Approach to Characterize the Impact of Pre- and Post-natal Oxycodone Exposure on Neurodevelopment and Behavior
    Katherine E. Odegaard, Victoria L. Schaal, Alexander R. Clark, Sneh Koul, Jagadesan Sankarasubramanian, Zhiqiu Xia, Melissa Mellon, Mariano Uberti, Yutong Liu, Andrew Stothert, Matthew Van Hook, Hanjun Wang, Chittibabu Guda, Steven J. Lisco, Gurudutt Pendyala, Sowmya V. Yelamanchili
    Frontiers in Cell and Developmental Biology 2021 8
  • Alterations of brain microstructures in a mouse model of prenatal opioid exposure detected by diffusion MRI
    Gregory G. Grecco, Syed Salman Shahid, Brady K. Atwood, Yu-Chien Wu
    Scientific Reports 2022 12 1
  • In utero methadone exposure permanently alters anatomical and functional connectivity: A preclinical evaluation
    Eric M. Chin, Yuma Kitase, Nethra K. Madurai, Shenandoah Robinson, Lauren L. Jantzie
    Frontiers in Pediatrics 2023 11
  • Thalamocortical functional connectivity in infants with prenatal opioid exposure correlates with severity of neonatal opioid withdrawal syndrome
    Rupa Radhakrishnan, Ramana V. Vishnubhotla, Zoe Guckien, Yi Zhao, Gregory M. Sokol, David M. Haas, Senthilkumar Sadhasivam
    Neuroradiology 2022 64 8
  • Co-occurrence of preconception maternal childhood adversity and opioid use during pregnancy: Implications for offspring brain development
    Madeleine C. Allen, Nora K. Moog, Claudia Buss, Elizabeth Yen, Hanna C. Gustafsson, Elinor L. Sullivan, Alice M. Graham
    Neurotoxicology and Teratology 2021 88
  • A review of the genomics of neonatal abstinence syndrome
    Elizabeth Yen, Nathan Gaddis, Lauren Jantzie, Jonathan M. Davis
    Frontiers in Genetics 2023 14
  • Cerebral perfusion and neurological examination characterise neonatal opioid withdrawal syndrome: a prospective cohort study
    Kristen L Benninger, Jin Peng, Mai-Lan Ho, Julia Newton, Danny J J Wang, Houchun H Hu, Ann R Stark, Jerome A Rusin, Nathalie L Maitre
    Archives of Disease in Childhood - Fetal and Neonatal Edition 2022 107 4
  • Sex differences in neonatal outcomes following prenatal opioid exposure
    Nethra K. Madurai, Lauren L. Jantzie, Elizabeth Yen
    Frontiers in Pediatrics 2024 12

More in this TOC Section

  • Frontal Paraventricular Cysts
  • Sodium MRI in Pediatric Brain Tumors
  • FRACTURE MR in Congenital Vertebral Anomalies
Show more PEDIATRIC NEUROIMAGING

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire