Brainstem Chipmunk Sign: A Diagnostic Imaging Clue across All Subtypes of Alexander Disease

Thaís Armangue; Matthew T. Whitehead; Davide Tonduti; Laura Farina; Ali Reza Tavasoli; Arastoo Vossough; Mariko L. Bennett; Ylenia Vaia; Geneviève Bernard; Ettore Salsano; Saadet Mercimek-Andrews; Amy Waldman; Adeline Vanderver

doi:10.3174/ajnr.A8220

Research ArticleNeurodegenerative Disorder Imaging

Brainstem Chipmunk Sign: A Diagnostic Imaging Clue across All Subtypes of Alexander Disease

Thaís Armangue, Matthew T. Whitehead, Davide Tonduti, Laura Farina, Ali Reza Tavasoli, Arastoo Vossough, Mariko L. Bennett, Ylenia Vaia, Geneviève Bernard, Ettore Salsano, Saadet Mercimek-Andrews, Amy Waldman and Adeline Vanderver

American Journal of Neuroradiology June 2024, 45 (6) 769-772; DOI: https://doi.org/10.3174/ajnr.A8220

Thaís Armangue

aFrom the Neuroimmunology Program (T.A.), Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)-Hospital Clinic, University of Barcelona, Barcelona, Spain

bNeurology Department (T.A.), Neuroimmunology Unit, Sant Joan de Deu Children’s Hospital, University of Barcelona, Barcelona, Spain

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Matthew T. Whitehead

cDepartment of Radiology (M.T.W., A.Vossough), Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania

dPerelman School of Medicine (M.T.W., A.Vossough, A.W., A.Vanderver), University of Pennsylvania, Philadelphia, Pennsylvania

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Davide Tonduti

eUnit of Pediatric Neurology (D.T., Y.V.), Center for Diagnosis and Treatment of Leukodystrophies, V. Buzzi Children’s Hospital, University of Milan, Milan, Italy

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Laura Farina

fNeuroimaging Laboratory (L.F.), IRCCS Fondazione Santa Lucia, Rome, Italy

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Ali Reza Tavasoli

gDepartment of Neurology (A.R.T.), Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran

hDepartment of Neurology (A.R.T.), Barrow Neurological Institute, Phoenix Children’s Hospital, Phoenix, Arizona

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Arastoo Vossough

cDepartment of Radiology (M.T.W., A.Vossough), Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania

dPerelman School of Medicine (M.T.W., A.Vossough, A.W., A.Vanderver), University of Pennsylvania, Philadelphia, Pennsylvania

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Mariko L. Bennett

oDivision of Neurology (M.L.B., Y.V., A.W., A.Vanderver), Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania.

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Ylenia Vaia

eUnit of Pediatric Neurology (D.T., Y.V.), Center for Diagnosis and Treatment of Leukodystrophies, V. Buzzi Children’s Hospital, University of Milan, Milan, Italy

oDivision of Neurology (M.L.B., Y.V., A.W., A.Vanderver), Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania.

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Geneviève Bernard

iDepartments of Neurology and Neurosurgery, Pediatrics, and Human Genetics (G.B.), McGill University, Montreal, Quebec, Canada

jDepartment of Specialized Medicine (G.B.), Division of Medical Genetics, McGill University Health Centre, Montreal, Quebec, Canada

kChild Health and Human Development Program (G.B.), Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada

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Ettore Salsano

lUnit of Rare Neurological Diseases (E.S.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy

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Saadet Mercimek-Andrews

mDepartment of Medical Genetics (S.M.-A.), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada

nThe Hospital for Sick Children (S.M.-A.), Toronto, Ontario, Canada

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Amy Waldman

dPerelman School of Medicine (M.T.W., A.Vossough, A.W., A.Vanderver), University of Pennsylvania, Philadelphia, Pennsylvania

oDivision of Neurology (M.L.B., Y.V., A.W., A.Vanderver), Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania.

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Adeline Vanderver

dPerelman School of Medicine (M.T.W., A.Vossough, A.W., A.Vanderver), University of Pennsylvania, Philadelphia, Pennsylvania

oDivision of Neurology (M.L.B., Y.V., A.W., A.Vanderver), Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania.

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Brainstem Chipmunk Sign: A Diagnostic Imaging Clue across All Subtypes of Alexander Disease

American Journal of Neuroradiology Jun 2024, 45 (6) 769-772; DOI: 10.3174/ajnr.A8220

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Brainstem Chipmunk Sign in Alexander Disease

American Journal of Neuroradiology Jun 2024, 45 (6) 769-772; DOI: 10.3174/ajnr.A8220

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