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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Review ArticleNeurovascular/Stroke Imaging

Pericarotid Fat as a Marker of Cerebrovascular Risk

Riccardo Cau, Nicoletta Anzalone, Lorenzo Mannelli, Myriam Edjlali, Antonella Balestrieri, Valentina Nardi, Giuseppe Lanzino, Amir Lerman, Jasjit S. Suri and Luca Saba
American Journal of Neuroradiology November 2024, 45 (11) 1635-1641; DOI: https://doi.org/10.3174/ajnr.A8300
Riccardo Cau
aFrom the Department of Radiology (R.C., A.B., L.S.), Azienda Ospedaliero Universitaria (A.O.U.), Cagliari, Italy
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  • ORCID record for Riccardo Cau
Nicoletta Anzalone
bVita-Salute San Raffaele University (N.A.), Milan, Italy
cNeuroradiology Unit and CERMAC (N.A.), IRCCS Ospedale San Raffaele, Milan, Italy
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Lorenzo Mannelli
dIRCCS SYNLAB SDN S.p.A. (L.M.), Naples, Italy
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Myriam Edjlali
eDepartment of Neuroradiology (M.E.), Université Paris-Descartes-Sorbonne-Paris-Cité, IMABRAIN-INSERM-UMR1266, DHU-Neurovasc, Centre Hospitalier Sainte-Anne, Paris, France
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Antonella Balestrieri
aFrom the Department of Radiology (R.C., A.B., L.S.), Azienda Ospedaliero Universitaria (A.O.U.), Cagliari, Italy
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Valentina Nardi
fDepartment of Neurosurgery (V.N., G.L.), Mayo Clinic, Rochester, Minnesota
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Giuseppe Lanzino
fDepartment of Neurosurgery (V.N., G.L.), Mayo Clinic, Rochester, Minnesota
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Amir Lerman
gDepartment of Cardiovascular Medicine (A.L.), Mayo Clinic College of Medicine, Rochester, Minnesota
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Jasjit S. Suri
hStroke Monitoring and Diagnostic Division (J.S.S.), AtheroPoint, Roseville, California
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  • ORCID record for Jasjit S. Suri
Luca Saba
aFrom the Department of Radiology (R.C., A.B., L.S.), Azienda Ospedaliero Universitaria (A.O.U.), Cagliari, Italy
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SUMMARY:

Vascular inflammation is widely recognized as an important factor in the atherosclerotic process, particularly in terms of plaque development and progression. Conventional tests, such as measuring circulating inflammatory biomarkers, lack the precision to identify specific areas of vascular inflammation. In this context, noninvasive imaging modalities can detect perivascular fat changes, serving as a marker of vascular inflammation. This review aims to provide a comprehensive overview of the key concepts related to perivascular carotid fat and its pathophysiology. Additionally, we examine the existing literature on the association of pericarotid fat with features of plaque vulnerability and cerebrovascular events. Finally, we scrutinize the advantages and limitations of the noninvasive assessment of pericarotid fat.

ABBREVIATIONS:

AI
artificial intelligence
AUC
area under the curve
HU
Hounsfield unit
PCF
pericarotid fat
PVAT
perivascular adipose tissue
US
ultrasound
USPIO
ultra-small superparamagnetic iron oxide particles
  • © 2024 by American Journal of Neuroradiology
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American Journal of Neuroradiology: 45 (11)
American Journal of Neuroradiology
Vol. 45, Issue 11
1 Nov 2024
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Cite this article
Riccardo Cau, Nicoletta Anzalone, Lorenzo Mannelli, Myriam Edjlali, Antonella Balestrieri, Valentina Nardi, Giuseppe Lanzino, Amir Lerman, Jasjit S. Suri, Luca Saba
Pericarotid Fat as a Marker of Cerebrovascular Risk
American Journal of Neuroradiology Nov 2024, 45 (11) 1635-1641; DOI: 10.3174/ajnr.A8300

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Pericarotid Fat: Cerebrovascular Risk Marker
Riccardo Cau, Nicoletta Anzalone, Lorenzo Mannelli, Myriam Edjlali, Antonella Balestrieri, Valentina Nardi, Giuseppe Lanzino, Amir Lerman, Jasjit S. Suri, Luca Saba
American Journal of Neuroradiology Nov 2024, 45 (11) 1635-1641; DOI: 10.3174/ajnr.A8300
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  • Article
    • SUMMARY:
    • ABBREVIATIONS:
    • PATHOPHYSIOLOGY OF PERIVASCULAR CAROTID FAT
    • NONINVASIVE EVALUATION OF PCF
    • ASSOCIATION WITH FEATURES OF PLAQUE VULNERABILITY
    • ASSOCIATION WITH CEREBROVASCULAR ISCHEMIC EVENTS
    • ASSOCIATION WITH POSTOPERATIVE INTERVENTIONAL COMPLICATION/OUTCOME
    • ASSOCIATION WITH NONATHEROSCLEROTIC CAROTID VASCULAR DISEASE
    • FUTURE DIRECTION: ARTIFICIAL INTELLIGENCE AND RADIOMICS
    • CONCLUSIONS
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • Responses
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This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Carotid Plaque-RADS Score Combined with Pericarotid Fat Density—An Incremental Prediction Model for Stroke Recurrence
    Jinhua Qian, Qinjie Chi, Li Zhu, Tianhao Zhang, Wenbing Ding, Ruifan Yuan, Zhuo Chen, Tianle Wang
    Academic Radiology 2025
  • Development of a nomogram model for predicting acute stroke events based on dual-energy CTA analysis of carotid intraplaque and perivascular adipose tissue
    He Zhang, Juan Long, Chenzi Wang, Xiaohan Liu, He Lu, Wenbei Xu, Xiaonan Sun, Peipei Dou, Dexing Zhou, Lili Zhu, Kai Xu, Yankai Meng
    Frontiers in Neurology 2025 16

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