Article Figures & Data
Figures
- FIG 1.
Sample calculation of thrombus perviousness/permeability on admission NCCT (left) and CTA (right). The image on the left demonstrates NCCT with 3 ROIs placed on the thrombus, with the thrombus attenuation in Hounsfield units calculated as the mean among the ROI values. The image on the right demonstrates a similar thrombus attenuation calculation on CTA. Perviousness was then calculated as the difference in Hounsfield units between CTA and NCCT. Likewise, the perviousness ratio was calculated as the ratio of Hounsfield units of the CTA over NCCT.
- FIG 2.
Volcano plot depicting the proteomic landscape of pervious acute ischemic stroke clots. The left side of the graph depicts proteins that are significantly depleted (red), while the right side depicts those that are differentially abundant (green).
- FIG 3.
Association between specific protein content and the thrombus perviousness ratio. The relation between increasing perviousness ratio and low-affinity FCGR2A/FcγRIIA (A), SYTL4 (B), TPM3 (C), hemoglobin subunit ζ (D), PYCARD/ASC (E), and dNTPase SAMHD1 (F).
- FIG 4.
Thrombus perviousness is associated with differential susceptibility to ADAMTS13-augmented thrombolysis. Ns indicates not significant. *P < .05.
Tables
Proteins with the most significant abundance and depletion in highly pervious clots
Protein Name log2fc P Value 40S Ribosomal protein S23 –0.690129341 .00039 Glutamine synthetase –1.606714657 .00073 40S Ribosomal protein S2 –0.413995286 .001 40S Ribosomal protein S12 –0.633724478 .001 60S Ribosomal protein L28 –0.519178688 .001 Aldehyde dehydrogenase, mitochondrial –0.593729139 .0019 60S Ribosomal protein L27 –0.321892776 .0022 40S Ribosomal protein S8 –0.658129234 .0022 Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial –0.348210926 .0023 Vesicle transport through interaction with t-SNAREs homolog 1B –0.540383664 .0027 Immunoglobulin heavy variable 1/OR15-1 (nonfunctional) (fragment) 0.85769177 .04 BCL2/adenovirus E1B 19 kDa protein-interacting protein 2.0.311 0.630567877 .015 Farnesyl pyrophosphate synthase 0.357444057 .013 Tropomyosin α-3 chain.0.2616 0.333697844 .005 GTPase NRAS.0.1703 0.316709736 .02 Cullin-4A..0.636 0.314913909 .04 V-type proton ATPase subunit G 1 0.285104241 .04 Protein phosphatase 1 regulatory subunit 7 0.232882868 .04 Dedicator of cytokinesis protein 10 0.231574532 .03
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