Characteristics of Radiation-Related Intracranial Aneurysms: A Multicenter Retrospective Study

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FIG 1.
A 52-year-old man with nasopharyngeal cancer (T4N2M0, stage IVA). T1-weighted image (1.5T) with contrast shows that the tumor (A, black stars) has grown into the skull base and embraces the left ICA (A, white arrows) with swollen lymph nodes bilaterally (A, white arrowhead). Five years after irradiation, the patient presented with headache, and a sidewall aneurysm (5.1 mm) was detected at the left ICA using CTA (B, white arrow).
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FIG 2.
A 43-year-old woman with vestibular schwannoma. Eight years after irradiation, SAH and a ruptured bifurcation aneurysm (2.7 mm) were diagnosed by noncontrast CT and CTA (A, white arrow), which was treated with endovascular coiling (B, white arrow). Note a funnel-shaped enlargement of the left internal auditory canal (A and B, black arrow).

Table 1:

Characteristics of the patients (n = 4160)

Characteristics	Radiation-Related Group (No.) (%)	Control Group (No.) (%)	P Value
Male	24 (70.6)	1730 (41.9)	.001
Age (mean) (yr)	51.4 (SD, 15.0)	58.2 (SD, 13.5)	.003
Hyperlipidemia	3 (8.8)	348 (8.4)	NS
Hypertension	15 (44.1)	2187 (53.0)	NS
Diabetes	2 (5.9)	281 (6.8)	NS
Multiple aneurysms	7 (20.6)	470 (11.4)	NS
Presented with SAH	30 (88.2)	2979 (72.2)	.037

Table 2:

Characteristics of the aneurysms (n = 4813)

Characteristics	Radiation-Related Group	Control Group	P Value
Aneurysm size (mean) (mm)	4.9 (SD, 2.3)	5.2 (SD, 2.2)	NS
Location of aneurysm (No.) (%)			.046
ICA	23 (53.5)	2015 (42.2)
Anterior cerebral artery	6 (14.0)	1213 (25.4)
MCA	6 (14.0)	1066 (22.3)
Posterior circulation artery	8 (18.6)	476 (10.0)
Type of aneurysm (No.) (%)			.048
Sidewall	20 (46.5)	1543 (32.3)
Bifurcation	23 (53.5)	3227 (67.7)
Irregular wall	12 (27.9)	1438 (30.1)	NS