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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleAdult Brain
Open Access

Disability Improvement Is Associated with Less Brain Atrophy Development in Multiple Sclerosis

E. Ghione, N. Bergsland, M.G. Dwyer, J. Hagemeier, D. Jakimovski, D.P. Ramasamy, D. Hojnacki, A.A. Lizarraga, C. Kolb, S. Eckert, B. Weinstock-Guttman and R. Zivadinov
American Journal of Neuroradiology September 2020, 41 (9) 1577-1583; DOI: https://doi.org/10.3174/ajnr.A6684
E. Ghione
aFrom the Department of Neurology (E.G., N.B., M.G.D., J.H., D.J., D.P.R., R.Z.), Buffalo Neuroimaging Analysis Center
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N. Bergsland
aFrom the Department of Neurology (E.G., N.B., M.G.D., J.H., D.J., D.P.R., R.Z.), Buffalo Neuroimaging Analysis Center
dIRCCS (N.B.), Fondazione Don Carlo Gnocchi ONLUS, Milan, Italy.
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M.G. Dwyer
aFrom the Department of Neurology (E.G., N.B., M.G.D., J.H., D.J., D.P.R., R.Z.), Buffalo Neuroimaging Analysis Center
cCenter for Biomedical Imaging at the Clinical Translational Science Institute (M.G.D., R.Z.),University at Buffalo, State University of New York, Buffalo, New York
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J. Hagemeier
aFrom the Department of Neurology (E.G., N.B., M.G.D., J.H., D.J., D.P.R., R.Z.), Buffalo Neuroimaging Analysis Center
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D. Jakimovski
aFrom the Department of Neurology (E.G., N.B., M.G.D., J.H., D.J., D.P.R., R.Z.), Buffalo Neuroimaging Analysis Center
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D.P. Ramasamy
aFrom the Department of Neurology (E.G., N.B., M.G.D., J.H., D.J., D.P.R., R.Z.), Buffalo Neuroimaging Analysis Center
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D. Hojnacki
bDepartment of Neurology (D.H., A.A.L., C.K., S.E., B.W.-G.), Jacobs Comprehensive MS Treatment and Research Center, Jacobs School of Medicine and Biomedical Sciences
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A.A. Lizarraga
bDepartment of Neurology (D.H., A.A.L., C.K., S.E., B.W.-G.), Jacobs Comprehensive MS Treatment and Research Center, Jacobs School of Medicine and Biomedical Sciences
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C. Kolb
bDepartment of Neurology (D.H., A.A.L., C.K., S.E., B.W.-G.), Jacobs Comprehensive MS Treatment and Research Center, Jacobs School of Medicine and Biomedical Sciences
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S. Eckert
bDepartment of Neurology (D.H., A.A.L., C.K., S.E., B.W.-G.), Jacobs Comprehensive MS Treatment and Research Center, Jacobs School of Medicine and Biomedical Sciences
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B. Weinstock-Guttman
bDepartment of Neurology (D.H., A.A.L., C.K., S.E., B.W.-G.), Jacobs Comprehensive MS Treatment and Research Center, Jacobs School of Medicine and Biomedical Sciences
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R. Zivadinov
aFrom the Department of Neurology (E.G., N.B., M.G.D., J.H., D.J., D.P.R., R.Z.), Buffalo Neuroimaging Analysis Center
cCenter for Biomedical Imaging at the Clinical Translational Science Institute (M.G.D., R.Z.),University at Buffalo, State University of New York, Buffalo, New York
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References

  1. 1.↵
    1. Frohman EM,
    2. Racke MK,
    3. Raine CS
    . Multiple sclerosis: the plaque and its pathogenesis. N Engl J Med 2006;354:942–55 doi:10.1056/NEJMra052130 pmid:16510748
    CrossRefPubMedWeb of Science
  2. 2.↵
    1. Calabrese M,
    2. Reynolds R,
    3. Magliozzi R, et al
    . Regional distribution and evolution of gray matter damage in different populations of multiple sclerosis patients. PLoS One 2015;10:e0135428 doi:10.1371/journal.pone.0135428 pmid:26267665
    CrossRefPubMed
  3. 3.↵
    1. Fisher E,
    2. Lee JC,
    3. Nakamura K, et al
    . Gray matter atrophy in multiple sclerosis: a longitudinal study. Ann Neurol 2008;64:255–65 doi:10.1002/ana.21436 pmid:18661561
    CrossRefPubMedWeb of Science
  4. 4.↵
    1. De Stefano N,
    2. Giorgio A,
    3. Battaglini M, et al
    . Assessing brain atrophy rates in a large population of untreated multiple sclerosis subtypes. Neurology 2010;74:1868–76 doi:10.1212/WNL.0b013e3181e24136 pmid:20530323
    Abstract/FREE Full Text
  5. 5.↵
    1. Zivadinov R,
    2. Sepcic J,
    3. Nasuelli D, et al
    . A longitudinal study of brain atrophy and cognitive disturbances in the early phase of relapsing-remitting multiple sclerosis. J Neurol Neurosurg Psychiatry 2001;70:773–80 doi:10.1136/jnnp.70.6.773 pmid:11385012
    Abstract/FREE Full Text
  6. 6.↵
    1. Miller DH,
    2. Barkhof F,
    3. Frank JA, et al
    . Measurement of atrophy in multiple sclerosis: pathological basis, methodological aspects and clinical relevance. Brain 2002;125:1676–95 doi:10.1093/brain/awf177 pmid:12135961
    CrossRefPubMedWeb of Science
  7. 7.↵
    1. Uher T,
    2. Horakova D,
    3. Kalincik T, et al
    . Early magnetic resonance imaging predictors of clinical progression after 48 months in clinically isolated syndrome patients treated with intramuscular interferon beta-1a. Eur J Neurol 2015;22:1113–23 doi:10.1111/ene.12716 pmid:25904020
    CrossRefPubMed
  8. 8.↵
    1. Lukas C,
    2. Minneboo A,
    3. de Groot V, et al
    . Early central atrophy rate predicts 5-year clinical outcome in multiple sclerosis. J Neurol Neurosurg Psychiatry 2010;81:1351–56 doi:10.1136/jnnp.2009.199968 pmid:20826873
    Abstract/FREE Full Text
  9. 9.↵
    1. Minneboo A,
    2. Jasperse B,
    3. Barkhof F, et al
    . Predicting short-term disability progression in early multiple sclerosis: added value of MRI parameters. J Neurol Neurosurg Psychiatry 2008;79:917–23 doi:10.1136/jnnp.2007.124123 pmid:18077480
    Abstract/FREE Full Text
  10. 10.↵
    1. Sanai SA,
    2. Saini V,
    3. Benedict RH, et al
    . Aging and multiple sclerosis. Mult Scler 2016;22:717–25 doi:10.1177/1352458516634871 pmid:26895718
    CrossRefPubMed
  11. 11.↵
    1. Sastre-Garriga J,
    2. Pareto D,
    3. Rovira A
    . Brain atrophy in multiple sclerosis: clinical relevance and technical aspects. Neuroimaging Clin N Am 2017;27:289–300 doi:10.1016/j.nic.2017.01.002 pmid:28391787
    CrossRefPubMed
  12. 12.↵
    1. Zivadinov R,
    2. Uher T,
    3. Hagemeier J, et al
    . A serial 10-year follow-up study of brain atrophy and disability progression in RRMS patients. Mult Scler 2016;22:1709–18 doi:10.1177/1352458516629769 pmid:26883943
    CrossRefPubMed
  13. 13.↵
    1. Coles AJ,
    2. Twyman CL,
    3. Arnold DL, et al
    . Alemtuzumab for patients with relapsing multiple sclerosis after disease-modifying therapy: a randomised controlled phase 3 trial. Lancet 2012;380:1829–39 doi:10.1016/S0140-6736(12)61768-1 pmid:23122650
    CrossRefPubMedWeb of Science
  14. 14.↵
    1. Calabresi PA,
    2. Radue EW,
    3. Goodin D, et al
    . Safety and efficacy of fingolimod in patients with relapsing-remitting multiple sclerosis (FREEDOMS II): a double-blind, randomised, placebo-controlled, Phase 3 trial. Lancet Neurol 2014;13:545–56 doi:10.1016/S1474-4422(14)70049-3 pmid:24685276
    CrossRefPubMedWeb of Science
  15. 15.↵
    1. Montalban X,
    2. Hauser SL,
    3. Kappos L, et al
    ; ORATORIO Clinical Investigators. Ocrelizumab versus placebo in primary progressive multiple sclerosis. N Engl J Med 2017;376:209–20 doi:10.1056/NEJMoa1606468 pmid:28002688
    CrossRefPubMed
  16. 16.↵
    1. Hauser SL,
    2. Bar-Or A,
    3. Comi G, et al
    ; OPERA I and OPERA II Clinical Investigators. Ocrelizumab versus interferon beta-1a in relapsing multiple sclerosis. N Engl J Med 2017;376:221–34 doi:10.1056/NEJMoa1601277 pmid:28002679
    CrossRefPubMed
  17. 17.↵
    1. O'Connor P,
    2. Wolinsky JS,
    3. Confavreux C, et al
    ; TEMSO Trial Group. Randomized trial of oral teriflunomide for relapsing multiple sclerosis. N Engl J Med 2011;365:1293–1303 doi:10.1056/NEJMoa1014656 pmid:21991951
    CrossRefPubMedWeb of Science
  18. 18.↵
    1. Borges IT,
    2. Shea CD,
    3. Ohayon J, et al
    . The effect of daclizumab on brain atrophy in relapsing-remitting multiple sclerosis. Mult Scler Relat Disord 2013;2:133–40 doi:10.1016/j.msard.2012.10.002 pmid:23580931
    CrossRefPubMed
  19. 19.↵
    1. Giovannoni G,
    2. Comi G,
    3. Cook S, et al
    ; CLARITY Study Group. A placebo-controlled trial of oral cladribine for relapsing multiple sclerosis. N Engl J Med 2010;362:416–26 doi:10.1056/NEJMoa0902533 pmid:20089960
    CrossRefPubMedWeb of Science
  20. 20.↵
    1. Chen JT,
    2. Collins DL,
    3. Atkins HL
    ; Canadian MS BMT Study Group. Brain atrophy after immunoablation and stem cell transplantation in multiple sclerosis. Neurology 2006;66:1935–37 doi:10.1212/01.wnl.0000219816.44094.f8 pmid:16801665
    Abstract/FREE Full Text
  21. 21.↵
    1. Sicotte NL,
    2. Giesser BS,
    3. Tandon V, et al
    . Testosterone treatment in multiple sclerosis: a pilot study. Arch Neurol 2007;64:683–88 doi:10.1001/archneur.64.5.683 pmid:27752863
    CrossRefPubMedWeb of Science
  22. 22.↵
    1. Uher T,
    2. Horakova D,
    3. Bergsland N, et al
    . MRI correlates of disability progression in patients with CIS over 48 months. Neuroimage Clin 2014;6:312–19 doi:10.1016/j.nicl.2014.09.015 pmid:25379444
    CrossRefPubMed
  23. 23.↵
    1. Polman CH,
    2. Reingold SC,
    3. Banwell B, et al
    . Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol 2011;69:292–302 doi:10.1002/ana.22366 pmid:21387374
    CrossRefPubMedWeb of Science
  24. 24.↵
    1. Gelineau-Morel R,
    2. Tomassini V,
    3. Jenkinson M, et al
    . The effect of hypointense white matter lesions on automated gray matter segmentation in multiple sclerosis. Hum Brain Mapp 2012;33:2802–14 doi:10.1002/hbm.21402 pmid:21976406
    CrossRefPubMed
  25. 25.↵
    1. Smith SM,
    2. Zhang Y,
    3. Jenkinson M, et al
    . Accurate, robust, and automated longitudinal and cross-sectional brain change analysis. Neuroimage 2002;17:479–89 doi:10.1006/nimg.2002.1040 pmid:12482100
    CrossRefPubMedWeb of Science
  26. 26.↵
    1. Dwyer MG,
    2. Silva D,
    3. Bergsland N, et al
    . Neurological software tool for reliable atrophy measurement (NeuroSTREAM) of the lateral ventricles on clinical-quality T2-FLAIR MRI scans in multiple sclerosis. Neuroimage Clin 2017;15:769–79 doi:10.1016/j.nicl.2017.06.022 pmid:28706852
    CrossRefPubMed
  27. 27.↵
    1. Zivadinov R,
    2. Rudick RA,
    3. De Masi R, et al
    . Effects of IV methylprednisolone on brain atrophy in relapsing-remitting MS. Neurology 2001;57:1239–47 doi:10.1212/WNL.57.7.1239 pmid:11591843
    Abstract/FREE Full Text
  28. 28.↵
    1. Coles AJ,
    2. Cohen JA,
    3. Fox EJ, et al
    ; CARE-MS II and CAMMS03409 Investigators. Alemtuzumab CARE-MS II 5-year follow-up: efficacy and safety findings. Neurology 2017;89:1117–26 doi:10.1212/WNL.0000000000004354 pmid:28835403
    Abstract/FREE Full Text
  29. 29.↵
    1. Correale J,
    2. Peirano I,
    3. Romano L
    . Benign multiple sclerosis: a new definition of this entity is needed. Mult Scler 2012;18:210–18 doi:10.1177/1352458511419702 pmid:21865415
    CrossRefPubMed
  30. 30.↵
    1. Ghione E,
    2. Bergsland N,
    3. Dwyer MG, et al
    . Brain atrophy is associated with disability progression in patients with MS followed in a clinical routine. AJNR Am J Neuroradiol 2018;39:2237–42 doi:10.3174/ajnr.A5876 pmid:30467212
    Abstract/FREE Full Text
  31. 31.↵
    1. Zivadinov R,
    2. Bergsland N,
    3. Korn JR, et al
    ; MS-MRIUS Study Group. Feasibility of brain atrophy measurement in clinical routine without prior standardization of the MRI protocol: results from MS-MRIUS, a longitudinal observational, multicenter real-world outcome study in patients with relapsing-remitting MS. AJNR Am J Neuroradiol 2018;39:289–95 doi:10.3174/ajnr.A5442 pmid:29170269
    Abstract/FREE Full Text
  32. 32.↵
    1. Ghione E,
    2. Bergsland N,
    3. Dwyer MG, et al
    . Aging and brain atrophy in multiple sclerosis. J Neuroimaging 2019;29:527–35 doi:10.1111/jon.12625 pmid:31074192
    CrossRefPubMed
  33. 33.↵
    1. Cree BA,
    2. Hollenbach JA,
    3. Bove R, et al
    ; University of California, San Francisco MS-EPIC Team. Silent progression in disease activity-free relapsing multiple sclerosis. Ann Neurol 2019;85:653–66 doi:10.1002/ana.25463 pmid:30851128
    CrossRefPubMed
  34. 34.↵
    1. Bakshi R,
    2. Healy BC,
    3. Dupuy SL, et al
    ; SUMMIT consortium. Brain MRI predicts worsening multiple sclerosis disability over 5 years in the SUMMIT Study. J Neuroimaging 2020;30:212–18 doi:10.1111/jon.12688 pmid:31994814
    CrossRefPubMed
  35. 35.↵
    1. Gauthier SA,
    2. Berger AM,
    3. Liptak Z, et al
    . Rate of brain atrophy in benign vs early multiple sclerosis. Arch Neurol 2009;66:234–37 doi:10.1001/archneurol.2008.567 pmid:19204160
    CrossRefPubMedWeb of Science
  36. 36.↵
    1. Sormani MP,
    2. Arnold DL,
    3. De Stefano N
    . Treatment effect on brain atrophy correlates with treatment effect on disability in multiple sclerosis. Ann Neurol 2014;75:43–49 doi:10.1002/ana.24018 pmid:24006277
    CrossRefPubMed
  37. 37.↵
    1. Cohen JA,
    2. Coles AJ,
    3. Arnold DL, et al
    . Alemtuzumab versus interferon beta 1a as first-line treatment for patients with relapsing-remitting multiple sclerosis: a randomised controlled Phase 3 trial. Lancet 2012;380:1819–28 doi:10.1016/S0140-6736(12)61769-3 pmid:23122652
    CrossRefPubMedWeb of Science
  38. 38.↵
    1. Jakimovski D,
    2. Gandhi S,
    3. Paunkoski I, et al
    . Hypertension and heart disease are associated with development of brain atrophy in multiple sclerosis: a 5-year longitudinal study. Eur J Neurol 2019;26:87–88 doi:10.1111/ene.13769 pmid:30103277
    CrossRefPubMed
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Cite this article
E. Ghione, N. Bergsland, M.G. Dwyer, J. Hagemeier, D. Jakimovski, D.P. Ramasamy, D. Hojnacki, A.A. Lizarraga, C. Kolb, S. Eckert, B. Weinstock-Guttman, R. Zivadinov
Disability Improvement Is Associated with Less Brain Atrophy Development in Multiple Sclerosis
American Journal of Neuroradiology Sep 2020, 41 (9) 1577-1583; DOI: 10.3174/ajnr.A6684

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Disability Improvement Is Associated with Less Brain Atrophy Development in Multiple Sclerosis
E. Ghione, N. Bergsland, M.G. Dwyer, J. Hagemeier, D. Jakimovski, D.P. Ramasamy, D. Hojnacki, A.A. Lizarraga, C. Kolb, S. Eckert, B. Weinstock-Guttman, R. Zivadinov
American Journal of Neuroradiology Sep 2020, 41 (9) 1577-1583; DOI: 10.3174/ajnr.A6684
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  • Thalamic atrophy measured by artificial intelligence in a multicentre clinical routine real-world study is associated with disability progression
    Robert Zivadinov, Niels Bergsland, Dejan Jakimovski, Bianca Weinstock-Guttman, Ralph H B Benedict, Jon Riolo, Diego Silva, Michael G Dwyer
    Journal of Neurology, Neurosurgery & Psychiatry 2022 93 10
  • Brain atrophy and lesion burden are associated with disability progression in a multiple sclerosis real-world dataset using only T2-FLAIR: The NeuroSTREAM MSBase study
    Michael Barnett, Niels Bergsland, Bianca Weinstock-Guttman, Helmut Butzkueven, Tomas Kalincik, Patricia Desmond, Frank Gaillard, Vincent van Pesch, Serkan Ozakbas, Juan Ignacio Rojas, Cavit Boz, Ayse Altintas, Chenyu Wang, Michael G. Dwyer, Suzie Yang, Dejan Jakimovski, Kain Kyle, Deepa P. Ramasamy, Robert Zivadinov
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  • Thalamic atrophy and dysconnectivity are associated with cognitive impairment in a multi-center, clinical routine, real-word study of people with relapsing-remitting multiple sclerosis
    Robert Zivadinov, Niels Bergsland, Dejan Jakimovski, Bianca Weinstock-Guttman, Lorena Lorefice, Menno M. Schoonheim, Sarah A. Morrow, Mary Ann Picone, Gabriel Pardo, Myassar Zarif, Mark Gudesblatt, Jacqueline A. Nicholas, Andrew Smith, Samuel Hunter, Stephen Newman, Mahmoud A. AbdelRazek, Ina Hoti, Jon Riolo, Diego Silva, Tom A. Fuchs, Michael G. Dwyer, Ralph HB. Benedict
    NeuroImage: Clinical 2024 42
  • Brain atrophy assessment in multiple sclerosis: technical– and subject-related barriers for translation to real-world application in individual subjects
    Robert Zivadinov, Ashley Tranquille, Jack A. Reeves, Michael G. Dwyer, Niels Bergsland
    Expert Review of Neurotherapeutics 2024 24 11

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