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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleAdult Brain
Open Access

White Matter Lesion Penumbra Shows Abnormalities on Structural and Physiologic MRIs in the Coronary Artery Risk Development in Young Adults Cohort

I.M. Nasrallah, M.-K. Hsieh, G. Erus, H. Battapady, S. Dolui, J.A. Detre, L.J. Launer, D.R. Jacobs, C. Davatzikos and R.N. Bryan
American Journal of Neuroradiology August 2019, 40 (8) 1291-1298; DOI: https://doi.org/10.3174/ajnr.A6119
I.M. Nasrallah
aFrom the Department of Radiology (I.M.N., R.N.B.)
bCenter for Biomedical Image Computing and Analytics (I.M.N., M.-K.H., G.E., H.B., C.D.)
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M.-K. Hsieh
bCenter for Biomedical Image Computing and Analytics (I.M.N., M.-K.H., G.E., H.B., C.D.)
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G. Erus
bCenter for Biomedical Image Computing and Analytics (I.M.N., M.-K.H., G.E., H.B., C.D.)
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H. Battapady
bCenter for Biomedical Image Computing and Analytics (I.M.N., M.-K.H., G.E., H.B., C.D.)
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S. Dolui
cDepartment of Neurology (S.D., J.A.D.), University of Pennsylvania, Philadelphia, Pennsylvania
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J.A. Detre
cDepartment of Neurology (S.D., J.A.D.), University of Pennsylvania, Philadelphia, Pennsylvania
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L.J. Launer
dNational Institute on Aging (L.J.L.), National Institutes of Health, Bethesda, Maryland
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D.R. Jacobs
eDivision of Epidemiology (D.R.J.), School of Public Health, University of Minnesota, Minneapolis, Minnesota.
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C. Davatzikos
bCenter for Biomedical Image Computing and Analytics (I.M.N., M.-K.H., G.E., H.B., C.D.)
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R.N. Bryan
aFrom the Department of Radiology (I.M.N., R.N.B.)
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Article Information

vol. 40 no. 8 1291-1298
DOI 
https://doi.org/10.3174/ajnr.A6119
PubMed 
31345946

Published By 
American Journal of Neuroradiology
Print ISSN 
0195-6108
Online ISSN 
1936-959X
History 
  • Received February 7, 2019
  • Accepted after revision June 6, 2019
  • Published online August 14, 2019.

Article Versions

  • Latest version (July 25, 2019 - 07:26).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2019 by American Journal of Neuroradiology Indicates open access to non-subscribers at www.ajnr.org

Author Information

  1. I.M. Nasrallaha,b,
  2. M.-K. Hsiehb,
  3. G. Erusb,
  4. H. Battapadyb,
  5. S. Doluic,
  6. J.A. Detrec,
  7. L.J. Launerd,
  8. D.R. Jacobse,
  9. C. Davatzikosb and
  10. R.N. Bryana
  1. aFrom the Department of Radiology (I.M.N., R.N.B.)
  2. bCenter for Biomedical Image Computing and Analytics (I.M.N., M.-K.H., G.E., H.B., C.D.)
  3. cDepartment of Neurology (S.D., J.A.D.), University of Pennsylvania, Philadelphia, Pennsylvania
  4. dNational Institute on Aging (L.J.L.), National Institutes of Health, Bethesda, Maryland
  5. eDivision of Epidemiology (D.R.J.), School of Public Health, University of Minnesota, Minneapolis, Minnesota.
  1. Please address correspondence to Ilya M. Nasrallah, MD, PhD, Department of Radiology, University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104; e-mail: ilya.nasrallah{at}pennmedicine.upenn.edu
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Funding

  • NIA

    AG0005
  • NIH/NHLBI

    HHSN268200900041C; HHSN268201300025C; HHSN268201300026C; HHSN268201300027C; HHSN268201300028C; HHSN268201300029C

Altmetrics

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I.M. Nasrallah, M.-K. Hsieh, G. Erus, H. Battapady, S. Dolui, J.A. Detre, L.J. Launer, D.R. Jacobs, C. Davatzikos, R.N. Bryan
White Matter Lesion Penumbra Shows Abnormalities on Structural and Physiologic MRIs in the Coronary Artery Risk Development in Young Adults Cohort
American Journal of Neuroradiology Aug 2019, 40 (8) 1291-1298; DOI: 10.3174/ajnr.A6119

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White Matter Lesion Penumbra Shows Abnormalities on Structural and Physiologic MRIs in the Coronary Artery Risk Development in Young Adults Cohort
I.M. Nasrallah, M.-K. Hsieh, G. Erus, H. Battapady, S. Dolui, J.A. Detre, L.J. Launer, D.R. Jacobs, C. Davatzikos, R.N. Bryan
American Journal of Neuroradiology Aug 2019, 40 (8) 1291-1298; DOI: 10.3174/ajnr.A6119
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Cited By...

  • Disconnectome Associated with Progressive Ischemic Periventricular White Matter Lesions
  • Crossref (13)
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Free-water diffusion MRI detects structural alterations surrounding white matter hyperintensities in the early stage of cerebral small vessel disease
    Carola Mayer, Felix L Nägele, Marvin Petersen, Benedikt M Frey, Uta Hanning, Ofer Pasternak, Elina Petersen, Christian Gerloff, Götz Thomalla, Bastian Cheng
    Journal of Cerebral Blood Flow & Metabolism 2022 42 9
  • Reliability of arterial spin labeling derived cerebral blood flow in periventricular white matter
    Sudipto Dolui, Audrey P. Fan, Moss Y. Zhao, Ilya M. Nasrallah, Greg Zaharchuk, John A. Detre
    Neuroimage: Reports 2021 1 4
  • Loss of Integrity of Corpus Callosum White Matter Hyperintensity Penumbra Predicts Cognitive Decline in Patients With Subcortical Vascular Mild Cognitive Impairment
    Yage Qiu, Ling Yu, Xin Ge, Yawen Sun, Yao Wang, Xiaowei Wu, Qun Xu, Yan Zhou, Jianrong Xu
    Frontiers in Aging Neuroscience 2021 13
  • Alzheimer’s and vascular disease classification using regional texture biomarkers in FLAIR MRI
    Karissa Chan, Corinne Fischer, Pejman Jabehdar Maralani, Sandra E. Black, Alan R. Moody, April Khademi
    NeuroImage: Clinical 2023 38
  • Increased white matter glycolysis in humans with cerebral small vessel disease
    Matthew R. Brier, Tyler Blazey, Marcus E. Raichle, John C. Morris, Tammie L. S. Benzinger, Andrei G. Vlassenko, Abraham Z. Snyder, Manu S. Goyal
    Nature Aging 2022 2 11
  • Characterizing the penumbras of white matter hyperintensities in patients with cerebral small vessel disease
    Xin Wang, Yu Wang, Deyu Gao, Zhichao Zhao, Haiping Wang, Sujie Wang, Shiguang Liu
    Japanese Journal of Radiology 2023 41 9
  • Diffusion tensor free water MRI predicts progression of FLAIR white matter hyperintensities after ischemic stroke
    Kyle C. Kern, Marwah S. Zagzoug, Rebecca F. Gottesman, Clinton B. Wright, Richard Leigh
    Frontiers in Neurology 2023 14
  • Associations of white matter hyperintensities with networks of gray matter blood flow and volume in midlife adults: A coronary artery risk development in young adults magnetic resonance imaging substudy
    William S. H. Kim, Nicholas J. Luciw, Sarah Atwi, Zahra Shirzadi, Sudipto Dolui, John A. Detre, Ilya M. Nasrallah, Walter Swardfager, Robert Nick Bryan, Lenore J. Launer, Bradley J. MacIntosh
    Human Brain Mapping 2022 43 12
  • Cerebrovascular reactivity in Alzheimer's disease signature regions is associated with mild cognitive impairment in adults with hypertension
    Vahan Aslanyan, Wendy J. Mack, Nancy E. Ortega, Ilya M. Nasrallah, Nicholas M. Pajewski, Jeff D. Williamson, Judy Pa
    Alzheimer's & Dementia 2024 20 3
  • Predicted disconnectome associated with progressive periventricular white matter ischemia
    Zhengjun Li, Sudipto Dolui, Mohamad Habes, Danielle S. Bassett, David Wolk, John A. Detre
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