Article Figures & Data
Figures
- Fig 1.
A 61-year-old woman with left hemiparesis who had right MCA (M1) occlusion (not shown) but sufficient collaterals on baseline conventional angiography. DWI shows right MCA territorial infarction. Processed perfusion maps show 3.5 mL of severe (ATD>6 seconds) hypoperfusion, 42 mL of moderate (ATD2–6 seconds) hypoperfusion, and a mean rCBV2–6 seconds of 1.7 within the hypoperfused area. The Perfusion Collateral Index is 42 × 1.7 = 71.4.
- Fig 2.
A 70-year-old woman with left paresis who had right MCA (M1) occlusion (not shown) and insufficient collaterals on baseline conventional angiography. DWI showed right MCA territorial infarction. Processed perfusion maps show 17 mL of severe (ATD>6 seconds) hypoperfusion, 20 mL of moderate (ATD2–6 seconds) hypoperfusion, and a mean rCBV2–6 seconds of 0.9 within the hypoperfused area. The perfusion collateral index is 20 × 0.9 = 18.
- Fig 3.
The Classification Tree model using a combination of the PCI (Volume of ATD2–6 seconds × rCBV2–6 seconds) and baseline infarction volume provides a nominal (not validated) 100% accuracy and ROC area = 1.0.
Tables
- Table 1:
Baseline and clinical data in patients with insufficient-versus-good collateral flow
Variable Overall (n = 39) Good Collaterals (n = 22) Insufficient Collaterals (n = 17) P Value Age (mean) (SD) (yr) 63.3 (13.3) 62.8 (15.3) 63.9 (10.2) .85 Sex (M/F) (22:17) (11:11) (11:6) .52 Baseline NIHSS score (median) (IQR) 17, 14–19 16, 13–18 18, 15–20 .19 IV tPA (No.) (%) 18 (46%) 10 (45%) 8 (47%) .45 Hr to groin puncture from last known well (median) (IQR) 6.10, 5.54–7.14 5.98, 5.67–7.54 6.08, 5.27–7.10 .93 Hr from MRI to groin puncture (median) (IQR)a 1.40, 0.80–2.20 1.10, 0.70–1.75 1.5, 0.90–2.14 .58 Note:—IQR indicates interquartile range.
↵a Subset analysis (only available for 20 patients, 13 patients with good collaterals and 7 patients with insufficient collaterals).
Variable Good Collaterals (n = 22) Insufficient Collaterals (n = 17) P Value Baseline infarct volume (mean) (SD) 29.7 (18.7) 48.3 (30.0) .021a Final infarct volume (mean) (SD) 51.1 (32.4) 81.0 (44.7) .030a ATD>6 s (vol) (mean) (SD) 24.7 (17.4) 42.4 (18.2) .004a ATD2–6 s (vol) (mean) (SD) 64.6 (25.0) 28.2 (17.1) <.001a rCBF2–6 s (mean) (SD) 1.16 (0.18) 0.98 (0.25) .026a rCBV2–6 s (mean) (SD) 1.92 (0.32) 1.17 (0.38) <.001a PCI (mean) (SD) 120.70 (47.6) 36.0 (25.8) <.001a Primary revascularization (DSA-TICI) (No.) (%)b 12 (54.5) 5 (29.4) .190 - Table 3:
Optimal threshold, sensitivity, specificity, overall accuracy, and ROC area imaging variables that were significant with univariate analysis
Variable Threshold Specificity Sensitivity Overall Accuracy ROC Area Base infarct volume (mL) 24.1 76.5% 63.6% 70.1% 0.717 Final infarct volume (mL) 45 82.4% 59.1% 70.7% 0.706 Volume of ATD>6 s (mL) 27.77 88.2% 63.6% 75.9% 0.777 Volume of ATD2–6 s (mL) 38.28 82.4% 81.8% 82.1% 0.906 rCBF 1 58.8% 90.9% 74.9% 0.709 rCBV2–6 s 1.6 88.2% 81.8% 85.0% 0.900 PCIa 61.70 88.2% 100.0% 94.1% 0.973 ↵a PCI = Volume of ATD2–6 seconds × rCBV2–6 seconds.
