Hippocampal Atrophy Is Associated with Altered Hippocampus–Posterior Cingulate Cortex Connectivity in Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis

The pipeline of MR imaging and statistical analyses. Multicontrast MR imaging examinations including T1WI, DSI, and resting-state fMRI were performed to measure HV and SC of the iCB and iFC between the hippocampus and the PCC, respectively. A linear regression model was used to evaluate the correlation of HV with SC and iFC indices, where Y is the volume ratio of the hippocampus and X₁ and X₂ are the SC and iFC of the HP-PCC connection, respectively. HP indicates hippocampus; rsfMR, resting-state fMRI.