Article Figures & Data
Figures
- Fig 1.
Examples of CT perfusion source data with perihematoma and external and internal borderzone ROIs. Maps of cerebral blood flow, cerebral blood volume, cerebral perfusion pressure, and cerebrovascular reserve at 2 different sections from a patient in the <180-mm Hg treatment group.
- Fig 2.
Mean (±SD) perihematoma and contralateral homologous region cerebral blood flow, cerebral blood volume, cerebral perfusion pressure, and cerebrovascular reserve.
- Fig 3.
Plots of cerebral perfusion pressure and cerebrovascular resistance against mean arterial pressure. The open circles refer to the <150-mm Hg treatment group, while the filled squares represent the <180-mm Hg treatment group. There was no relationship between mean arterial pressure and CPP (β = −0.08 [−0.10, 0.05]) or CVR (β = −0.11 [−0.003, 0.001]).
Tables
Characteristic <150-mm Hg Target (n = 37) <180-mm Hg Target (n = 36) P Value Age (yr) 71.0 ± 12.5 68.7 ± 11.1 .40 Male 26 (70%) 28 (78%) .47 Symptom onset to randomization (hr) 10.5 ± 7.4 9.7 ± 7.0 .65 Medical history Hypertension 26 (70%) 27 (75%) .71 Previous ICH 4 (11%) 1 (3%) .19 Antiplatelet/anticoagulation 4 (11%) 4 (11%) .74 Ischemic stroke 6 (16%) 2 (6%) .17 Clinical characteristics Systolic BP (mm Hg) 182 ± 20 184 ± 25 .66 Diastolic BP (mm Hg) 94 ± 19 97 ± 23 .53 Mean arterial pressure (mm Hg) 123 ± 17 126 ± 22 .54 Glasgow Coma Scale 13.3 ± 2.7 13.9 ± 1.9 .27 NIHSS score 12.3 ± 7.7 11.5 ± 6.3 .64 Hematoma characteristics Basal ganglia 28 (76%) 27 (75%) .99 Lobar 9 (24%) 8 (22%) Cerebellum 0 (0%) 1 (3%) Intraparenchymal volume (mL) 24.5 ± 28.9 22.61 ± 21.35 .75 Intraventricular volume (mL) 2.20 ± 6.26 4.25 ± 8.78 .26 Total ICH volume (mL) 26.68 ± 31.50 26.86 ± 25.24 .98 Antihypertensive therapyb Labetalol (No.) (mean dose ± SD in mg) 34 (38 ± 25) 16 (29 ± 25) Hydralazine (No.) (mean dose ± SD in mg) 18 (22 ± 14) 5 (14 ± 8) IV enalapril (No.) (mean dose ± SD in mg) 9 (1.25 ± 0) 3 (1.25 ± 0) Outcomes Mortality (No.) (%) 7 (19) 4 (11) .52 Modified Rankin Scale score (median) (IQR) 3 (1.5–5.5) 4 (2–5) .43 Hematoma growth >6 mL (No.) (%) 8 (21) 8 (22) .86 Perfusion Parameters and Region Treatment Group P Value <150 mm Hg (n = 37) <180 mm Hg (n = 36) Absolute ipsilateral CPP Perihematoma 13.9 ± 5.5 14.8 ± 3.4 .38 Hemisphere 14.0 ± 5.3 15.2 ± 3.9 .27 External BZ 14.1 ± 4.6 15.8 ± 4.6 (n = 35) .11 Internal BZ 13.5 ± 4.6 (n = 27) 16.5 ± 4.7 (n = 29) .02a Absolute contralateral CPP Perihematoma 13.9 ± 5.5 14.8 ± 4.0 .43 Hemisphere 14.3 ± 5.8 15.2 ± 3.8 .45 External BZ 15.1 ± 6.5 16.0 ± 3.7 (n = 35) .46 Internal BZ 15.0 ± 7.1 (n = 27) 16.0 ± 4.6 (n = 29) .48 Absolute ipsilateral CVR Perihematoma 0.32 ± 0.10 0.36 ± 0.11 .11 Hemisphere 0.29 ± 0.08 0.32 ± 0.08 .14 External BZ 0.31 ± 0.11 0.37 ± 0.12 (n = 35) .05a Internal BZ 0.37 ± 0.13 (n = 27) 0.44 ± 0.16 (n = 29) .08 Absolute contralateral CVR Perihematoma 0.28 ± 0.09 0.33 ± 0.11 .56 Hemisphere 0.28 ± 0.08 0.32 ± 0.09 .09 External BZ 0.32 ± 0.11 0.38 ± 0.12 (n = 35) .04a Internal BZ 0.36 ± 0.12 (n = 27) 0.40 ± 0.14 (n = 29) .16 Relative CPP Perihematoma 1.02 ± 0.16 1.02 ± 0.15 .96 Hemisphere 0.99 ± 0.09 1.00 ± 0.10 .75 External BZ 0.99 ± 0.19 1.00 ± 0.26 (n = 35) .76 Internal BZ 1.01 ± 0.17 (n = 27) 1.01 ± 0.16 (n = 29) .99 Relative CVR Perihematoma 1.16 ± 0.23 1.11 ± 0.17 .36 Hemisphere 1.04 ± 0.10 1.02 ± 0.08 .32 External BZ 1.01 ± 0.18 1.01 ± 0.22 (n = 35) .91 Internal BZ 1.02 ± 0.17 (n = 27) 1.04 ± 0.15 (n = 29) .52 ↵a Significant.
Jump to section
Related Articles
Cited By...
- No citing articles found.