Article Figures & Data
Tables
Characteristic Microbleeds Absent P Valuea Microbleeds Present P Valueb Lobar Microbleeds Only Mixed Lobar and Deep Gray/ Infratentorial Microbleeds Deep Gray/Infratentorial Microbleeds Only No. of subjects 407 163 29 27 Mean age (SD), y 72 (7.6) <.001c 74 (7.0) 77 (6.4) 77 (9.0) .06 Sex, male/female 218:189 .15 100:63 17:12 14:13 .64 Mean education (SD), y 16 (2.6) .24 16 (2.9) 16 (2.9) 16 (2.3) .78 % with HTN 47 .28 46 72 67 .009d % with APOE4 43 .15 53 52 26 .03d % with APOE2 allele 7 >.99 6 7 19 .06 % with NL 26 .14 20 10 33 .10 % with MCI 61 .80 61 79 56 .33 % with AD 12 .18 18 10 11 .41 Note:—HTN indicates hypertension; MCI, mild cognitive impairment; NL, normal cognitive function; SD, standard deviation.
↵a P values compare baseline variables between those without microbleeds and those with microbleeds (combining the 3 groups with different types of microbleeds).
↵b P values compare baseline variables among the 3 groups with microbleeds.
↵c Significance according to the Wilcoxon rank sum test.
↵d Significance according to the χ2 test.
- Table 2:
Regression model demonstrating association between lobar microbleeds and CSF amyloid-β level (log transformed)
CSF Aβ (Log Transformed) Coefficient (95% CI) P Value No. of lobar microbleeds 1 −0.005 (−0.057 to 0.047) .85 2 −0.030 (−0.12 to 0.056) .49 3 −0.30 (−0.48 to −0.12) .001 >3 −0.18 (−0.29 to −0.068) .002 Age −0.007 (−0.0098 to −0.0041) <.001 Male sex −0.013 (−0.055 to −0.030) .57 Years of education 0.003 (−0.0046 to 0.011) .40 APOE4 −0.23 (−0.28 to −0.19) <.001 APOE2 0.059 (−0.022 to 0.14) .15 MCI −0.078 (−0.13 to −0.028) .002 AD −0.26 (−0.33 to −0.19) <.001 History of hypertension −0.011 (−0.052 to 0.031) .61 Note:—MCI indicates mild cognitive impairment.
- Table 3:
Regression model demonstrating association between lobar microbleeds and likelihood of an abnormal CSF p-tau level
Abnormal CSF p-Tau Level Odds Ratio (95% CI) P Value No. of lobar microbleeds 1 2.82 (1.52–5.24) .001 2 1.24 (0.51–3.01) .64 3 0.37 (0.081–1.73) .21 >3 3.22 (0.40–25.9) .27 Abnormal CSF Aβ level 3.40 (2.16–5.34) <.001 Age 1.01 (0.99–1.04) .32 Male sex 0.93 (0.61–1.42) .74 Years of education 0.98 (0.90–1.06) .56 APOE4 2.33 (1.42–3.84) .001 APOE2 1.02 (0.52–2.02) .95 MCI 1.05 (0.67–1.67) .83 AD 3.5 (1.15–10.7) .03 History of hypertension 0.98 (0.65–1.48) .92 Note:—MCI indicates mild cognitive impairment.
- Table 4:
Mixed-effects regression model demonstrating an association between lobar microbleeds and longitudinal change in ADAS
No. of Lobar Microbleeds Annual Change in ADAS (95% CI) P Value 0 0.78 (0.52 to 1.03) <.001 1 1.35 (0.92 to 1.78) .025 2 0.36 (−0.61 to 1.32) .41 3 0.50 (−2.07 to 3.07) .83 >3 2.34 (1.51 to 3.18) <.001
