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Improved Turnaround Times | Median time to first decision: 12 days

Research ArticleBrain

Optimal MRI Sequence for Identifying Occlusion Location in Acute Stroke: Which Value of Time-Resolved Contrast-Enhanced MRA?

A. Le Bras, H. Raoult, J.-C. Ferré, T. Ronzière and J.-Y. Gauvrit
American Journal of Neuroradiology June 2015, 36 (6) 1081-1088; DOI: https://doi.org/10.3174/ajnr.A4264
A. Le Bras
aFrom the Departments of Neuroradiology (A.L.B., H.R., J.-C.F., J.-Y.G.)
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H. Raoult
aFrom the Departments of Neuroradiology (A.L.B., H.R., J.-C.F., J.-Y.G.)
cUnité VISAGE U746 INSERM-INRIA, IRISA UMR CNRS 6074 (H.R., J.-C.F., J.-Y.G.), University of Rennes, Rennes, France.
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J.-C. Ferré
aFrom the Departments of Neuroradiology (A.L.B., H.R., J.-C.F., J.-Y.G.)
cUnité VISAGE U746 INSERM-INRIA, IRISA UMR CNRS 6074 (H.R., J.-C.F., J.-Y.G.), University of Rennes, Rennes, France.
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T. Ronzière
bNeurology (T.R.), Centre Hospitalier Universitaire Rennes, Rennes, France
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J.-Y. Gauvrit
aFrom the Departments of Neuroradiology (A.L.B., H.R., J.-C.F., J.-Y.G.)
cUnité VISAGE U746 INSERM-INRIA, IRISA UMR CNRS 6074 (H.R., J.-C.F., J.-Y.G.), University of Rennes, Rennes, France.
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    Fig 1.

    ICA segmentation used for the occlusion-level definition derived from Gibo et al, 1981.31 The internal carotid artery is divided into supraclinoid ICA, intracavernous and intrapetrous ICA, and cervical/extracranial ICA.

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    Fig 2.

    In patient 11, agreement between TR-CE MRA and DSA and discordance with TOF. A, 3D-TOF frontal MIP image shows complete occlusion of the left ICA from the IICA to distal segments of the left MCA. No data were available on the patency of the ICA proximal to the IICA segment (white arrow). B, Frontal DSA shows opacification of the left ICA up to the supraclinoid segment (white arrow). C, GRE T2 axial image displays a susceptibility vessel sign in the M1 segment of the left MCA. D, Frontal MIP TR-CE MRA shows patency of the left ICA up to the SCICA in the last phases (white arrows).

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    Fig 3.

    In patient 1, disagreement between TR-CE MRA and DSA and discordance with TOF. A, 3D-TOF frontal MIP image shows complete occlusion of the right ICA from the IICA to distal segments of the left MCA, with a doubt about the patency of the ICA proximal to the IICA segment (white arrow). B, Frontal DSA shows opacification of the right ICA up to the M1 segment (white arrow). C, Frontal MIP TR-CE MRA shows patency of the right ICA up to the SCICA in the last phases (white arrows).

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    Fig 4.

    Examples of occlusion and stenosis of the extracranial arteries.TR-CE MRA and its corresponding frontal DSA image. In patient 7 (A and B), occlusion of the left ICA, probably of atheromatous etiology (white arrow) on TR-CE MRA (A) and DSA (B). In patient 24 (C and D), severe stenosis (>50%) of the right ICA, on TR-CE MRA (C) and DSA (D), presumed due to an arterial dissection (white arrow).

Tables

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    Table 1:

    Acquisition parameters for MRA sequences

    TR-CE MRA3D-TOFGRE T2
    Receive coilBody coil8-Channel brain coil8-Channel brain coil
    TR/TE (ms)4.0/1.2523/3.5757/16.1
    Flip angle25°15°18°
    Acquisition planeCoronalAxialAxial
    FOV (mm)320 × 320200 × 200230 × 230
    Acquisition matrix268 × 267312 × 206512 × 512
    Section thickness (after interpolation)2.6 (1.3)1.6 (0.8)5
    Acquired voxel size (mm)1.2 × 1.2 × 2.60.64 × 0.97 × 1.60.45 × 0.45 × 5
    Reconstructed voxel size (mm)0.8 × 0.8 × 1.30.39 × 0.39 × 0.8
    No. of sections778724
    Anteroposterior coverage (mm)100
    k-t BLAST undersampling factor4––
    No. of dynamics121–
    Phase acquisition times8.7 sec––
    Total acquisition times1 minute 44 seconds2 minutes 36 seconds1 minute 37 seconds
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    Table 2:

    Identification of intracranial occlusion location with 3D-TOF, GRE T2, and TR-CE MRA, compared with DSA as the standard referencea

    Occlusion LocationDSA (No.) (%)3D-TOF MRA (No.) (%)GRE T2 (No.) (%)TR-CE MRA (No.) (%)
    No occlusion (no susceptibility vessel sign for GRE T2)0 (0%)0 (0%)6 (17.6%)0 (0%)
    ExCICA3 (8.8%)5 (14.7%)0 (0%)3 (8.8%)
    IICA0 (0%)5 (14.7%)0 (0%)0 (0%)
    SCICA8 (23.5%)3 (8.8%)3 (8.8%)9 (26.5%)
    M117 (50.0%)20 (58.8%)22 (64.7%)19 (55.9%)
    M26 (17.6%)1 (2.9%)2 (5.9%)3 (8.8%)
    κ0.430.310.81
    95% CI0.26−0.600.15−0.480.60−1
    (% of agreement)61.8%55.9%88.2%
    • ↵a Intracranial occlusion location with 3D-TOF, GRE T2, and TR-CE MRA, compared with DSA as the standard reference, showing the occlusion level detected as well as κ and percentage of agreement with DSA for each MRI sequence.

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American Journal of Neuroradiology: 36 (6)
American Journal of Neuroradiology
Vol. 36, Issue 6
1 Jun 2015
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A. Le Bras, H. Raoult, J.-C. Ferré, T. Ronzière, J.-Y. Gauvrit
Optimal MRI Sequence for Identifying Occlusion Location in Acute Stroke: Which Value of Time-Resolved Contrast-Enhanced MRA?
American Journal of Neuroradiology Jun 2015, 36 (6) 1081-1088; DOI: 10.3174/ajnr.A4264

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Optimal MRI Sequence for Identifying Occlusion Location in Acute Stroke: Which Value of Time-Resolved Contrast-Enhanced MRA?
A. Le Bras, H. Raoult, J.-C. Ferré, T. Ronzière, J.-Y. Gauvrit
American Journal of Neuroradiology Jun 2015, 36 (6) 1081-1088; DOI: 10.3174/ajnr.A4264
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