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Research ArticleBrain
Open Access

White Matter Alterations in the Brains of Patients with Active, Remitted, and Cured Cushing Syndrome: A DTI Study

P. Pires, A. Santos, Y. Vives-Gilabert, S.M. Webb, A. Sainz-Ruiz, E. Resmini, I. Crespo, M. de Juan-Delago and B. Gómez-Anson
American Journal of Neuroradiology June 2015, 36 (6) 1043-1048; DOI: https://doi.org/10.3174/ajnr.A4322
P. Pires
aFrom the Asociación para la Innovación en Análisis, Gestión y Procesamiento de Datos Científicos y Tecnológicos (P.P., Y.V.-G.), Barcelona, Spain
bDepartments of Endocrinology/Medicine (P.P., A.S., S.M.W., E.R., I.C.), Hospital Sant Pau, IIB-Sant Pau, Instituto de Salud Carlos III, and Universitat Autònoma de Barcelona, Barcelona, Spain
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A. Santos
bDepartments of Endocrinology/Medicine (P.P., A.S., S.M.W., E.R., I.C.), Hospital Sant Pau, IIB-Sant Pau, Instituto de Salud Carlos III, and Universitat Autònoma de Barcelona, Barcelona, Spain
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Y. Vives-Gilabert
aFrom the Asociación para la Innovación en Análisis, Gestión y Procesamiento de Datos Científicos y Tecnológicos (P.P., Y.V.-G.), Barcelona, Spain
cPort d'Informació Científica (Y.V.-G., A.S.-R.), Bellaterra, Barcelona, Spain
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S.M. Webb
bDepartments of Endocrinology/Medicine (P.P., A.S., S.M.W., E.R., I.C.), Hospital Sant Pau, IIB-Sant Pau, Instituto de Salud Carlos III, and Universitat Autònoma de Barcelona, Barcelona, Spain
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A. Sainz-Ruiz
cPort d'Informació Científica (Y.V.-G., A.S.-R.), Bellaterra, Barcelona, Spain
dInstitut de Fisica d'Altes Energies (A.S.-R.), Barcelona, Spain
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E. Resmini
bDepartments of Endocrinology/Medicine (P.P., A.S., S.M.W., E.R., I.C.), Hospital Sant Pau, IIB-Sant Pau, Instituto de Salud Carlos III, and Universitat Autònoma de Barcelona, Barcelona, Spain
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I. Crespo
bDepartments of Endocrinology/Medicine (P.P., A.S., S.M.W., E.R., I.C.), Hospital Sant Pau, IIB-Sant Pau, Instituto de Salud Carlos III, and Universitat Autònoma de Barcelona, Barcelona, Spain
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M. de Juan-Delago
eNeuroradiology Unit (M.d.J.-D., B.G.-A.), Hospital Sant Pau, IIB-Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
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B. Gómez-Anson
eNeuroradiology Unit (M.d.J.-D., B.G.-A.), Hospital Sant Pau, IIB-Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
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References

  1. 1.↵
    1. Newell-Price J
    . Cushing's syndrome. Clin Med 2008;8:204–08
    FREE Full Text
  2. 2.↵
    1. Hatipoglu BA
    . Cushing's syndrome. J Surg Oncol 2012;106:565–71
    CrossRefPubMed
  3. 3.↵
    1. Guaraldi F,
    2. Salvatori R
    . Cushing syndrome: maybe not so uncommon of an endocrine disease. J Am Board Fam Med 2012;25:199–208
    Abstract/FREE Full Text
  4. 4.↵
    1. Sapolsky RM,
    2. Krey LC,
    3. McEwen BS
    . The neuroendocrinology of stress and aging: the glucocorticoid cascade hypothesis. Endocr Rev 1986;7:284–301
    CrossRefPubMedWeb of Science
  5. 5.↵
    1. Riddle DR
    1. Goosens KA,
    2. Sapolsky RM
    . Stress and glucocorticoid contributions to normal and pathological aging. In Riddle DR, ed. Brain Aging: Models, Methods, and Mechanisms. Boca Raton: CRC Press; 2007:305–22
  6. 6.↵
    1. Bohn MC,
    2. Friedrich VL Jr.
    . Recovery of myelination in rat optic nerve after developmental retardation by cortisol. J Neurosci 1982;2:1292–98
    Abstract
  7. 7.↵
    1. Alonso G
    . Prolonged corticosterone treatment of adult rats inhibits the proliferation of oligodendrocyte progenitors present throughout white and gray matter regions of the brain. Glia 2000;31:219–31
    CrossRefPubMedWeb of Science
  8. 8.↵
    1. Miyata S,
    2. Koyama Y,
    3. Takemoto K, et al
    . Plasma corticosterone activates SGK1 and induces morphological changes in oligodendrocytes in corpus callosum. PLoS One 2011;6:e19859
    CrossRefPubMed
  9. 9.↵
    1. Fallo F,
    2. Sonino N
    . Should we evaluate for cardiovascular disease in patients with Cushing's syndrome? Clin Endocrinol 2009;71:768–71
    CrossRefPubMed
  10. 10.↵
    1. Aulinas A,
    2. Valassi E,
    3. Webb SM
    . Prognosis of patients treated for Cushing syndrome. Endocrinol Nutr 2014;61:52–61
    CrossRefPubMed
  11. 11.↵
    1. Miljic P,
    2. Miljic D,
    3. Cain JW, et al
    . Pathogenesis of vascular complications in Cushing's syndrome. Hormones (Athens) 2012;11:21–30
    PubMed
  12. 12.↵
    1. Trethowan WH,
    2. Cobb S
    . Neuropsychiatric aspects of Cushing's syndrome. AMA Arch Neurol Psychiatry 1952;67:283–309
    CrossRefPubMed
  13. 13.↵
    1. Cope O,
    2. Raker JW
    . Cushing's disease: the surgical experience in the care of 46 cases. N Engl J Med 1955;253:119–27
    CrossRefPubMedWeb of Science
  14. 14.↵
    1. Starkman MN,
    2. Gebarski SS,
    3. Berent S, et al
    . Hippocampal formation volume, memory dysfunction, and cortisol levels in patients with Cushing's syndrome. Biol Psychiatry 1992;32:756–65
    CrossRefPubMedWeb of Science
  15. 15.↵
    1. Simmons NE,
    2. Do HM,
    3. Lipper MH, et al
    . Cerebral atrophy in Cushing's disease. Surg Neurol 2000;53:72–76
    CrossRefPubMedWeb of Science
  16. 16.↵
    1. Resmini E,
    2. Santos A,
    3. Gómez-Anson B, et al
    . Verbal and visual memory performance and hippocampal volumes, measured by 3-Tesla magnetic resonance imaging, in patients with Cushing's syndrome. J Clin Endocrinol Metab 2012;97:663–71
    CrossRefPubMedWeb of Science
  17. 17.↵
    1. van der Werff SJ,
    2. Andela CD,
    3. Nienke Pannekoek J, et al
    . Widespread reductions of white matter integrity in patients with long-term remissions of Cushing's disease. Neuroimage Clin 2014;4:659–67
    CrossRefPubMed
  18. 18.↵
    1. Johansen-Berg H,
    2. Rushworth MF
    . Using diffusion imaging to study human connectional anatomy. Annu Rev Neurosci 2009;32:75–94
    CrossRefPubMedWeb of Science
  19. 19.↵
    1. Le Bihan D,
    2. Breton E,
    3. Lallemand D, et al
    . MR imaging of intravoxel incoherent motions: application to diffusion and perfusion in neurologic disorders. Radiology 1986;161:401–07
    CrossRefPubMedWeb of Science
  20. 20.↵
    1. Le Bihan D
    . Looking into the functional architecture of the brain with diffusion MRI. Nat Rev Neurosci 2003;4:469–80
    CrossRefPubMedWeb of Science
  21. 21.↵
    1. Alexander AL,
    2. Lee JE,
    3. Lazar M, et al
    . Diffusion tensor imaging of the brain. Neurotherapeutics 2007;4:316–29
    CrossRefPubMedWeb of Science
  22. 22.↵
    1. Budde MD,
    2. Xie M,
    3. Cross AH, et al
    . Axial diffusivity is the primary correlate of axonal injury in the experimental autoimmune encephalomyelitis spinal cord: a quantitative pixelwise analysis. J Neurosci 2009;29:2805–13
    Abstract/FREE Full Text
  23. 23.↵
    1. Hsu JL,
    2. Chen YL,
    3. Leu JG, et al
    . Microstructural white matter abnormalities in type 2 diabetes mellitus: a diffusion tensor imaging study. Neuroimage 2012;59:1098–105
    CrossRefPubMedWeb of Science
  24. 24.↵
    1. Smith SM,
    2. Jenkinson M,
    3. Woolrich MW, et al
    . Advances in functional and structural MR image analysis and implementation as FSL. Neuroimage 2004;23(suppl 1):S208–19
    CrossRefPubMedWeb of Science
  25. 25.↵
    1. Smith SM
    . Fast robust automated brain extraction. Hum Brain Mapp 2002;17:143–55
    CrossRefPubMedWeb of Science
  26. 26.↵
    1. Smith SM,
    2. Jenkinson M,
    3. Johansen-Berg H, et al
    . Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data. Neuroimage 2006;31:1487–505
    CrossRefPubMedWeb of Science
  27. 27.↵
    1. Horsfield MA,
    2. Jones DK
    . Applications of diffusion-weighted and diffusion tensor MRI to white matter diseases: a review. NMR Biomed 2002;15:570–77
    CrossRefPubMedWeb of Science
  28. 28.↵
    1. Beaulieu C
    . The basis of anisotropic water diffusion in the nervous system: a technical review. NMR Biomed 2002;15:435–55
    CrossRefPubMedWeb of Science
  29. 29.↵
    1. Song SK,
    2. Yoshino J,
    3. Le TQ, et al
    . Demyelination increases radial diffusivity in corpus callosum of mouse brain. Neuroimage 2005;26:132–40
    CrossRefPubMedWeb of Science
  30. 30.↵
    1. Wheeler-Kingshott CA,
    2. Cercignani M
    . About “axial” and “radial” diffusivities. Magn Res Med 2009;61:1255–60
    CrossRefPubMedWeb of Science
  31. 31.↵
    1. Jones DK,
    2. Knösche TR,
    3. Turner R
    . White matter integrity, fiber count, and other fallacies: the do's and don'ts of diffusion MRI. Neuroimage 2013;73:239–54
    CrossRefPubMedWeb of Science
  32. 32.↵
    1. Minati L,
    2. Grisoli M,
    3. Bruzzone MG
    . MR spectroscopy, functional MRI, and diffusion-tensor imaging in the aging brain: a conceptual review. J Geriatr Psychiatry Neurol 2007;20:3–21
    Abstract/FREE Full Text
  33. 33.↵
    1. Burzynska AZ,
    2. Preuschhof C,
    3. Bäckman L, et al
    . Age-related differences in white matter microstructure: region-specific patterns of diffusivity. Neuroimage 2010;49:2104–12
    CrossRefPubMedWeb of Science
  34. 34.↵
    1. Bourdeau I,
    2. Bard C,
    3. Noël B, et al
    . Loss of brain volume in endogenous Cushing's syndrome and its reversibility after correction of hypercortisolism. J Clin Endocrinol Metab 2002;87:1949–54
    CrossRefPubMedWeb of Science
  35. 35.↵
    1. Starkman MN,
    2. Giordani B,
    3. Gebarski SS, et al
    . Decrease in cortisol reverses human hippocampal atrophy following treatment of Cushing's disease. Biol Psychiatry 1999;46:1595–602
    CrossRefPubMedWeb of Science
  36. 36.↵
    1. Resmini E,
    2. Santos A,
    3. Gómez-Anson B, et al
    . Hippocampal dysfunction in cured Cushing's syndrome patients, detected by (1) H-MR-spectroscopy. Clin Endocrinol (Oxf) 2013;79:700–07
    PubMed
  37. 37.↵
    1. Sorrells ,
    2. Sapolsky RM
    . An inflammatory review of glucocorticoid actions in the CNS. Brain Behav Immun 2007;21:259–72
    CrossRefPubMed
  38. 38.↵
    1. Barahona MJ,
    2. Sucunza N,
    3. Resmini E, et al
    . Persistent body fat mass and inflammatory marker increases after long-term cure of Cushing's syndrome. J Clin Endocrinol Metab 2009;94:3365–71
    CrossRefPubMedWeb of Science
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P. Pires, A. Santos, Y. Vives-Gilabert, S.M. Webb, A. Sainz-Ruiz, E. Resmini, I. Crespo, M. de Juan-Delago, B. Gómez-Anson
White Matter Alterations in the Brains of Patients with Active, Remitted, and Cured Cushing Syndrome: A DTI Study
American Journal of Neuroradiology Jun 2015, 36 (6) 1043-1048; DOI: 10.3174/ajnr.A4322

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White Matter Alterations in the Brains of Patients with Active, Remitted, and Cured Cushing Syndrome: A DTI Study
P. Pires, A. Santos, Y. Vives-Gilabert, S.M. Webb, A. Sainz-Ruiz, E. Resmini, I. Crespo, M. de Juan-Delago, B. Gómez-Anson
American Journal of Neuroradiology Jun 2015, 36 (6) 1043-1048; DOI: 10.3174/ajnr.A4322
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