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Research ArticleSpine

Incidence of Inadvertent Intravascular Injection during CT Fluoroscopy–Guided Epidural Steroid Injections

P.G. Kranz, T.J. Amrhein and L. Gray
American Journal of Neuroradiology May 2015, 36 (5) 1000-1007; DOI: https://doi.org/10.3174/ajnr.A4219
P.G. Kranz
aFrom the Department of Radiology, Duke University Medical Center, Durham, North Carolina.
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T.J. Amrhein
aFrom the Department of Radiology, Duke University Medical Center, Durham, North Carolina.
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L. Gray
aFrom the Department of Radiology, Duke University Medical Center, Durham, North Carolina.
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    Fig 1.

    Classification scheme for the location of visualized vessels seen during inadvertent intravascular injection in the lumbar (A) and cervical (B) spine. Regions include the following: posterior paraspinal soft tissues (zone 1), spinal canal (zone 2), foraminal region (zone 3), vertebral body (zone 4), and anterior paraspinal soft tissues (zone 5).

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    Fig 2.

    Intravascular injection during lumbar TFESI. Preinjection (A), immediate postinjection (B), and delayed postinjection (C) images demonstrate a vessel in the left foraminal zone (arrow) that washes out on the delayed image.

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    Fig 3.

    A case of intravascular injection is demonstrated on preinjection (A), immediate postinjection (B), first delayed (C) images, and an additional delayed (D) image. On the immediate postinjection image, contrast is seen in the ascending lumbar vein (arrow) and the inferior vena cava (arrowhead). There is washout of contrast from the inferior vena cava on the first delayed image and from the ascending lumbar vein on the second delayed image.

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    Fig 4.

    Intravascular contrast seen both close to and more remote from the needle tip. Preinjection (A), immediate postinjection (B), and delayed postinjection (C) images show intravascular contrast at the needle tip (arrowhead) and further away (arrows) in the sacral epidural venous plexus. Note that these vessels are not seen on the delayed washout image. No epidural contrast is seen.

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    Fig 5.

    Immediate contrast washout. Preinjection (A), immediate postinjection (B), and delayed postinjection (C) images obtained after injection of 1.0-mL contrast. Neither vascular nor epidural contrast is seen. A preceding injection with 0.2-mL contrast showed similar negative findings, and images obtained cranial and caudal to the needle tip showed no contrast (images not shown).

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    Fig 6.

    Delayed contrast washout pattern. Preinjection (A), immediate postinjection (B), and delayed postinjection (C) images demonstrate intravascular contrast (arrows) that progressively washes out on delayed images. After needle repositioning (D), re-injection of contrast shows only epidural contrast spread.

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    Fig 7.

    Intravascular injection during cervical ILESI. Preinjection (A), immediate postinjection (B), and delayed postinjection (C) images demonstrate a vessel in the left neural foramen (arrowhead) that washes out on the delayed image.

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    Fig 8.

    Simultaneous epidural and intravascular injection. Preinjection (A), immediate postinjection (B), and delayed postinjection (C) images demonstrate a vessel extending into the anterior paraspinal soft tissues (arrowhead) that washes out on the delayed image. Epidural contrast in the neural foramen (arrow) persists on the delayed image. Note that there is contrast in the epidural space of the spinal canal on the preinjection image due to prior injection at an adjacent level.

Tables

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    Table 1:

    Assessment criteria for vessel type seen during intravascular injection

    ScoreVesselSuggestive Features
    5Definite veinFlow into a specific, anatomically identifiable venous structure
    4Probable veinFlow into region of known venous structure, flow predominantly away from spinal canal, delayed washout
    3IndeterminateNot meeting criteria for other categories
    2Probable arteryFlow into region of known arterial structure, flow predominantly toward the spinal canal, rapid washout
    1Definite arteryFlow into a specific, anatomically identifiable arterial structure
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    Table 2:

    Frequency of intravascular injection by anatomic zonea

    Injection TypeAnatomic Zone of Identified VesselNo. of Injections
    123450
    Lumbar ILESI25%100%25%0%0%0%4
    Lumbar TFESI14%18%86%5%36%0%22
    Cervical ILESI0%100%50%0%50%0%4
    Cervical TFESI29%0%71%0%14%14%7
    • ↵a Percentages across each injection type may sum to >100% because vessels may be visualized in >1 location simultaneously.

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    Table 3:

    Characteristics of identified vascular injections

    n%
    Distance from needle tip to vessel
        <1 cm only1130%
        >1 cm only25%
        Both <1 cm and >1 cm2362%
        Immediate washout (vessel not seen)13%
    Combined epidural injection
        Vascular only2568%
        Epidural + vascular1232%
    Washout pattern
         None00%
         Delayed3286%
         Immediate514%
    Vessel type
         Definite venous (n = 5)411%
         Probable venous (n = 4)2773%
         Indeterminate (n = 3)411%
         Probable arterial (n = 2)25%
         Definite arterial (n = 1)00%
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American Journal of Neuroradiology: 36 (5)
American Journal of Neuroradiology
Vol. 36, Issue 5
1 May 2015
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Cite this article
P.G. Kranz, T.J. Amrhein, L. Gray
Incidence of Inadvertent Intravascular Injection during CT Fluoroscopy–Guided Epidural Steroid Injections
American Journal of Neuroradiology May 2015, 36 (5) 1000-1007; DOI: 10.3174/ajnr.A4219

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Incidence of Inadvertent Intravascular Injection during CT Fluoroscopy–Guided Epidural Steroid Injections
P.G. Kranz, T.J. Amrhein, L. Gray
American Journal of Neuroradiology May 2015, 36 (5) 1000-1007; DOI: 10.3174/ajnr.A4219
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